Effect of flavonoids rich extract of Capparis spinosa on inflammatory involved genes in amyloid-beta peptide injected rat model of Alzheimer's disease

Nutritional Neuroscience

Volumn 21, Issue 2, 2018, Pages 143-150

  Mohebali, Nazanin ^a   Shahzadeh Fazeli, Seyed Abolhassan ^a,b   Ghafoori, Hossein ^c   Farahmand, Zeinab ^b   MohammadKhani, Elham ^b   Vakhshiteh, Faezeh ^b   Ghamarian, Abdolreza ^b   Farhangniya, Mansoureh ^b   Sanati, Mohammad Hossein ^d  

^a UNIVERSITY OF SCIENCE AND CULTURE   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

^c UNIVERSITY OF GUILAN   (Iran)

^d NATIONAL INSTITUTE OF GENETIC ENGINEERING AND BIOTECHNOLOGY   (Iran)

Author keywords

Alzheimer's disease; Capparis spinosa; Flavonoids; Gene expression; Rutin

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; CAPPARIS SPINOSA EXTRACT; FLAVONOID; KETAMINE; PRESENILIN 1; PRESENILIN 2; QUERCETIN; RUTOSIDE DERIVATIVE; UNCLASSIFIED DRUG; XYLAZINE; PLANT EXTRACT; RUTOSIDE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CAPPARIS SPINOSA; CONTROLLED STUDY; DOWN REGULATION; DPPH RADICAL SCAVENGING ASSAY; FERRIC REDUCING ANTIOXIDANT POWER ASSAY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATION; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; ANIMAL; CAPPARIS; CHEMISTRY; FRUIT; GENETICS; PLANT LEAF; WISTAR RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CAPPARIS; FLAVONOIDS; FRUIT; MALE; PLANT EXTRACTS; PLANT LEAVES; QUERCETIN; RATS; RATS, WISTAR; RUTIN;

EID: 84992371822     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1080/1028415X.2016.1238026     Document Type: Article

References (43)

1. Reitz C, Brayne C, Mayeux R., Epidemiology of Alzheimer disease. Nat Rev Neurol 2011;7:137–52. doi: 10.1038/nrneurol.2011.2
2. De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV., Alzheimer's disease. Subcell Biochem 2012;65:329–52. doi: 10.1007/978-94-007-5416-4_14
3. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D., Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. The Lancet 1993;342(8878):1007–11. doi: 10.1016/0140-6736(93)92876-U
4. Le Marchand L, Murphy SP, Hankin JH, Wilkens LR, Kolonel LN., Intake of flavonoids and lung cancer. JNCI J Natl Cancer Inst 2000;92(2):154–60. doi: 10.1093/jnci/92.2.154
5. Knekt P, Kumpulainen J, Järvinen R, Rissanen H, Heliövaara M, Reunanen A, et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002;76(3):560–8.
6. Rice-Evans C, Miller N, Paganga G., Antioxidant properties of phenolic compounds. Trends Plant Sci 1997;2(4):152–9. doi: 10.1016/S1360-1385(97)01018-2
7. Nijveldt RJ., Flavonoids: a review of probable mechanism of action and potential applications. AM J Clin Nutr 2001;74:418–25.
8. Guardia T, Ester Rotelli A, Osvaldo Juarez A, Pelzer LE., Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. II Farmaco. 2001;56(9):683–7. doi: 10.1016/S0014-827X(01)01111-9
9. La Casa C, Villegas I, Alarcón de la Lastra C, Motilva V, Martín Calero MJ., Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 2000;71(1–2):45–53. doi: 10.1016/S0378-8741(99)00174-9
10. 4-intoxicated BALB/cN mice. Acta Pharmacol Sin 2012;33:1260–70. doi: 10.1038/aps.2012.62
11. Lee C-C, Shen S-R, Laib Y-J, Wu S-C., Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury. Food Funct 2013;5:794–802. doi: 10.1039/c3fo30389f
12. Habtemariam SH., Rutin as a natural therapy for Alzheimer's disease: insights into its mechanisms of action. Curr Med Chem 2016;23(9):860–73. doi: 10.2174/0929867323666160217124333
13. Al-Said MS, Abdelsattar EA, Khalifa SI, El-Feraly FS., Isolation and identification of an anti-inflammatory principle from Capparis spinosa. Pharmazie 1988;43:640–1.
14. Bhoyar MS, Mishra GP, Naik PK, Srivastava RB., Estimation of antioxidant activity and total phenolics among natural populations of caper (‘Capparis spinosa’) leaves collected from cold arid desert of trans-Himalayas. Aust J Crop Sci 2011;5(7):912–9.
15. Tezcan F, Kolaylı S, Sahin H, Ulusoy E, Erim BF., Evaluation of organic acid, saccharide composition and antioxidant properties of some authentic Turkish honeys. J Food Nutr Resour 2011;50:33–40.
16. Germanò MP, De Pasquale R, D'Angelo V, Catania S, Silvari V, Costa C., Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source. J Agric Food Chem 2002;50(5):1168–71. doi: 10.1021/jf010678d
17. Aliyazicioglu R, Eyupoglu OE, Sahin H, Yildiz O, Baltas N., Phenolic components, antioxidant activity, and mineral analysis of Capparis spinosa L. Afr J Biotechnol 2013;12(47):6643–9. doi: 10.5897/AJB2013.13241
18. Romeo V, Ziino M, Giuffrida D, Condurso C, Verzera A., Flavour profile of capers (Capparis spinosa L.) from the Eolian archipelago by HS-SPME/ GC-MS. Food Chem 2006;101:1272–8. doi: 10.1016/j.foodchem.2005.12.029
19. Jakobek L, Seruga M, Novak I, Medvidovic-Kosanovic M., Flavonols, phenolic acids and antioxidant activity of some red fruits. Dtsch Lebensmitt-Rundsch 2007;103(8):369–78.
20. Kim DO, Jeong SW, Lee CY., Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem 2003;81:321–6. doi: 10.1016/S0308-8146(02)00423-5
21. Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M, Morelli I., Antioxidant principles from Bauhinia tarapotensis. J Nat Prod 2001;64(7):892–5. doi: 10.1021/np0100845
22. Benzie IF, Strain JJ., The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 1996;239(1):70–6. doi: 10.1006/abio.1996.0292
23. Paxinos G, Watson C., The rat brain in stereotaxic coordinates. San Diego: Academic Press; 2007.
24. Chiu K, Lau WM, Lau HT, So K-F, Chang RC-C., Micro-dissection of rat brain for RNA or protein extraction from specific brain region. J Vis Exp 2007;7:269. Pubmed Central PMCID: PMC2565859.
25. Hu N, Yu JT, Tan L, Wang YL, Sun L, Tan L., Nutrition and the risk of Alzheimer's disease. BioMed Res Int 2013;2013:1–12.
26. Luchsinger JA, Mayeux R., Dietary factors and Alzheimer's disease. Lancet Neurol 2004;3(10):579–87. doi: 10.1016/S1474-4422(04)00878-6
27. Shah R., The role of nutrition and diet in Alzheimer disease: a systematic review. J Am Med Dir Assoc 2013;14(6):398–402. doi: 10.1016/j.jamda.2013.01.014
28. Dai Q, Borenstein AR, Wu Y, Jackson JC, Larson EB., Fruit and vegetable juices and Alzheimer's disease: the kame project. Am J Med 2006;119(9):751–9. doi: 10.1016/j.amjmed.2006.03.045
29. Gomez-Pinilla F, Nguyen TT., Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders. Nutr Neurosci 2012;15(3):127–33. doi: 10.1179/1476830511Y.0000000035
30. Essa MM, Vijayan RK, Castellano-Gonzalez G, Memon MA, Braidy N, Guillemin GJ., Neuroprotective effect of natural products against Alzheimer's disease. Neurochem Res 2012;37(9):1829–42. doi: 10.1007/s11064-012-0799-9
31. Hashimoto M, Rockenstein E, Crews L, Masliah E., Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases. Neuromolecular Med 2003;4(1–2):21–35. doi: 10.1385/NMM:4:1-2:21
32. Harkany T, O'mahony S, Keijser J, Kelly JP, Kónya C, Borostyánkoi ZA., β-Amyloid (1–42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiol Dis 2001;8(4):667–78. doi: 10.1006/nbdi.2001.0398
33. Garcia-Osta A, Alberini CM., Amyloid beta mediates memory formation. Learn Memory 2009;16(4):267–72. doi: 10.1101/lm.1310209
34. Zhang YY, Fan YC, Wang M, Wang D, Li XH., Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1–42-induced rat model of Alzheimer's disease. Clin Intervent Aging 2013;8:103.
35. Tlili N, Khalidi A, Triki S, Munne-Bosch S., Phenolic compounds and vitamin antioxidants of Caper (Capparis spinosa). Plant Foods Hum Nutr 2010;65:260–5. doi: 10.1007/s11130-010-0180-6
36. Bonina F, Puglia C, Ventura D, Aquino R, Tortora S, Sacchi A, et al. In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds. J cosmet sci 2002;53(6):321–35.
37. Patel V, Sharma V, Patidar A., Quantitative analysis of rutin and quercetin in Capparis spinosa and Brassica oleracea by HPLC. Int J Pharm L Sci 2014; 5(8):3720–4.
38. Moghaddasian B, EradatmandAsli D, Eghdami A., Determination of rutin content in Caper (Capparis spinosa) by three analytical methods. Ann Biol Res 2012;3(9):4303–6.
39. Jiménez-Aliaga K, Bermejo-Bescós P, Benedí J, Martín-Aragón S., Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPs we cells. Life Sci 2011;89(25–26):939–45. Epub 2011 Oct 8. doi: 10.1016/j.lfs.2011.09.023
40. Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H., Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 2008;19(13):1329–33. doi: 10.1097/WNR.0b013e32830b8ae1
41. Delabio R, Rasmussen L, Mizumoto I, Viani GA, Chen E, Villares J, et al. PSEN1 and PSEN2 gene expression in Alzheimer's disease brain: a new approach. J Alzheimers Dis 2014;42(3):757–60.
42. Tan J, Shytle D, Rezai-Zadeh K., Inventors; University of South Florida, Tampa, Fl, assignee. Flavonoid treatment of glycogen synthase kinase based disease patent US8802638 B1. 2014.
43. Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, et al. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract Proc Natl Acad Sci 2002;99:12197–202 doi: 10.1073/pnas.182425199