Differential hepatoprotective mechanisms of rutin and quercetin in CCl 4-intoxicated BALB/cN mice

Acta Pharmacologica Sinica

Volumn 33, Issue 10, 2012, Pages 1260-1270

  Domitrović, Robert ^a   Jakovac, Hrvoje ^a   Vasiljev Marchesi, Vanja ^a   Vladimir Knežević, Sanda ^b   Cvijanović, Olga ^a   Tadić, Žarko ^a   Romić, Željko ^c   Rahelić, Dario ^c  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c University of Zagreb School of Medicine   (Croatia)

Author keywords

carbon tetrachloride (CCl4) poisoning; cyclooxygenase 2; heme oxygenase 1; hepatotoxicity; NF E2 related factor 2; nitric oxide synthase; nuclear factor kappa B; quercetin; rutin; transforming growth factor 1; tumor necrosis factor a

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CYCLOOXYGENASE 2; GLUTATHIONE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; QUERCETIN; RUTOSIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; HEPATITIS; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; BIPHENYL COMPOUNDS; CARBON TETRACHLORIDE POISONING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FREE RADICAL SCAVENGERS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NITRIC OXIDE; OXIDATIVE STRESS; PICRATES; QUERCETIN; RUTIN;

EID: 84867194602     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.62     Document Type: Article

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