메뉴 건너뛰기




Volumn 31, Issue 10, 2016, Pages 2231-2244

Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3

Author keywords

algorithm; blastocyst; decision support tool; embryo selection; implantation; morphokinetic; prediction model; time lapse

Indexed keywords

OXYGEN;

EID: 84992349032     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dew188     Document Type: Article
Times cited : (183)

References (68)
  • 1
    • 84975458604 scopus 로고    scopus 로고
    • Improved implantation rates of day 3 embryo transfers with the use of an automated time-lapse-enabled test to aid in embryo selection
    • Adamson GD, Abusief ME, Palao L, Witmer J, Palao LM, Gvakharia M. Improved implantation rates of day 3 embryo transfers with the use of an automated time-lapse-enabled test to aid in embryo selection. Fertil Steril 2016;105:369-375.
    • (2016) Fertil Steril , vol.105 , pp. 369-375
    • Adamson, G.D.1    Abusief, M.E.2    Palao, L.3    Witmer, J.4    Palao, L.M.5    Gvakharia, M.6
  • 4
    • 84963945648 scopus 로고    scopus 로고
    • Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate
    • Epub ahead of print
    • Aguilar J, Rubio I, Muñoz E, Pellicer A, Meseguer M. Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate. Fertil Steril 2016. doi:10. 1016/j. fertnstert. 2016. 03. 036. (Epub ahead of print).
    • (2016) Fertil Steril
    • Aguilar, J.1    Rubio, I.2    Muñoz, E.3    Pellicer, A.4    Meseguer, M.5
  • 5
    • 81055124854 scopus 로고    scopus 로고
    • Trophectoderm morphology: An important parameter for predicting live birth after single blastocyst transfer
    • Ahlström A, Westin C, Reismer E, Wikland M, Hardarson T. Trophectoderm morphology: An important parameter for predicting live birth after single blastocyst transfer. Hum Reprod 2011;26:3289-3296.
    • (2011) Hum Reprod , vol.26 , pp. 3289-3296
    • Ahlström, A.1    Westin, C.2    Reismer, E.3    Wikland, M.4    Hardarson, T.5
  • 6
    • 79957533987 scopus 로고    scopus 로고
    • The Istanbul consensus workshop on embryo assessment: Proceedings of an expert meeting
    • Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology
    • Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011;26:1270-1283.
    • (2011) Hum Reprod , vol.26 , pp. 1270-1283
  • 8
    • 84864959425 scopus 로고    scopus 로고
    • The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture
    • Azzarello A, Hoest T, Mikkelsen AL. The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture. Hum Reprod 2012;27:2649-2457.
    • (2012) Hum Reprod , vol.27 , pp. 2457-2649
    • Azzarello, A.1    Hoest, T.2    Mikkelsen, A.L.3
  • 9
    • 84929466934 scopus 로고    scopus 로고
    • The use of morphokinetics as a predictor of implantation: A multicentric study to define and validate an algorithm for embryo selection
    • Basile N, Vime P, Florensa M, Aparicio Ruiz B, Garcia Velasco JA, Remohi J, Meseguer M. The use of morphokinetics as a predictor of implantation: A multicentric study to define and validate an algorithm for embryo selection. Hum Reprod 2015;30:276-283.
    • (2015) Hum Reprod , vol.30 , pp. 276-283
    • Basile, N.1    Vime, P.2    Florensa, M.3    Aparicio Ruiz, B.4    Garcia Velasco, J.A.5    Remohi, J.6    Meseguer, M.7
  • 10
    • 84903631475 scopus 로고    scopus 로고
    • Testing a published embryo selection algorithm on independent time-lapse data
    • Best L, Campbell A, Duffy S, Montgomery S, Fishel S. Testing a published embryo selection algorithm on independent time-lapse data. Hum Reprod 2013;28:87-90.
    • (2013) Hum Reprod , vol.28 , pp. 87-90
    • Best, L.1    Campbell, A.2    Duffy, S.3    Montgomery, S.4    Fishel, S.5
  • 11
    • 84946473530 scopus 로고    scopus 로고
    • Influence of different oocyte insemination techniques on early and late morphokinetic parameters: A retrospective analysis of 500 time-lapse monitored blastocysts
    • Bodri D, Sugimoto T, Serna JY, Kondo M, Kato R, Kawachiya S, Matsumoto T. Influence of different oocyte insemination techniques on early and late morphokinetic parameters: A retrospective analysis of 500 time-lapse monitored blastocysts. Fertil Steril 2015;104:1175-1181.
    • (2015) Fertil Steril , vol.104 , pp. 1175-1181
    • Bodri, D.1    Sugimoto, T.2    Serna, J.Y.3    Kondo, M.4    Kato, R.5    Kawachiya, S.6    Matsumoto, T.7
  • 12
    • 84881192326 scopus 로고    scopus 로고
    • Retrospective analysis of outcomes after IVF using an aneuploidy risk model derived from time-lapse imaging without PGS
    • Campbell A, Fishel S, Bowman N, Duffy S, Sedler M, Thornton S. Retrospective analysis of outcomes after IVF using an aneuploidy risk model derived from time-lapse imaging without PGS. Reprod BioMed Online 2013b;27:140-146.
    • (2013) Reprod BioMed Online , vol.27 , pp. 140-146
    • Campbell, A.1    Fishel, S.2    Bowman, N.3    Duffy, S.4    Sedler, M.5    Thornton, S.6
  • 14
    • 84922074403 scopus 로고    scopus 로고
    • Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points
    • Cetinkaya M, Pirkevi C, Yelke H, Colakoglu YK, Atayurt Z, Kahraman S. Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points. J Assist Reprod Genet 2015;32:27-35.
    • (2015) J Assist Reprod Genet , vol.32 , pp. 27-35
    • Cetinkaya, M.1    Pirkevi, C.2    Yelke, H.3    Colakoglu, Y.K.4    Atayurt, Z.5    Kahraman, S.6
  • 16
    • 84867402737 scopus 로고    scopus 로고
    • Time-lapse evaluation of human embryo development in single versus sequential culture media- A sibling oocyte study
    • Ciray HN, Aksoy T, Goktas C, Ozturk B, Bahceci M. Time-lapse evaluation of human embryo development in single versus sequential culture media- A sibling oocyte study. J Assist Reprod Genet 2012;29:891-900.
    • (2012) J Assist Reprod Genet , vol.29 , pp. 891-900
    • Ciray, H.N.1    Aksoy, T.2    Goktas, C.3    Ozturk, B.4    Bahceci, M.5
  • 17
    • 84923900248 scopus 로고    scopus 로고
    • Proposed guidelines on the nomenclature and annotation of dynamic human embryo monitoring by a time-lapse user group
    • Ciray HN, Campbell A, Agerholm IE, Aguilar J, Chamayou S, Esbert M, Sayed S. Proposed guidelines on the nomenclature and annotation of dynamic human embryo monitoring by a time-lapse user group. Hum Reprod 2014;29:2650-2660.
    • (2014) Hum Reprod , vol.29 , pp. 2650-2660
    • Ciray, H.N.1    Campbell, A.2    Agerholm, I.E.3    Aguilar, J.4    Chamayou, S.5    Esbert, M.6    Sayed, S.7
  • 20
    • 84867096049 scopus 로고    scopus 로고
    • Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality
    • Cruz M, Garrido N, Herrero J, Perez-Cano I, Muñoz M, Meseguer M. Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality. Reprod BioMed Online 2012;25: 371-381.
    • (2012) Reprod BioMed Online , vol.25 , pp. 371-381
    • Cruz, M.1    Garrido, N.2    Herrero, J.3    Perez-Cano, I.4    Muñoz, M.5    Meseguer, M.6
  • 23
    • 84863187304 scopus 로고    scopus 로고
    • The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles
    • Diamond MP, Willman S, Chenette P, Cedars MI. The clinical need for a method of identification of embryos destined to become a blastocyst in assisted reproductive technology cycles. J Assist Reprod Genet 2012;29: 391-396.
    • (2012) J Assist Reprod Genet , vol.29 , pp. 391-396
    • Diamond, M.P.1    Willman, S.2    Chenette, P.3    Cedars, M.I.4
  • 25
    • 84908245362 scopus 로고    scopus 로고
    • Frequency of embryo multinucleation detected by time-lapse system and its impact on pregnancy outcome
    • Ergin EG, Caliskan E, Yalcinkaya E, Oztel Z, Cokelez K, Ozay A, Ozornek HM. Frequency of embryo multinucleation detected by time-lapse system and its impact on pregnancy outcome. Fertil Steril 2014;102:1029-1033.
    • (2014) Fertil Steril , vol.102 , pp. 1029-1033
    • Ergin, E.G.1    Caliskan, E.2    Yalcinkaya, E.3    Oztel, Z.4    Cokelez, K.5    Ozay, A.6    Ozornek, H.M.7
  • 26
    • 33646023117 scopus 로고    scopus 로고
    • An introduction to ROC analysis
    • Fawcett T. An introduction to ROC analysis. Pattern Recognit Lett 2006;27:861-874.
    • (2006) Pattern Recognit Lett , vol.27 , pp. 861-874
    • Fawcett, T.1
  • 27
    • 84878521464 scopus 로고    scopus 로고
    • Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women
    • Freour T, Dessolle L, Lammers J, Lattes S, Barrière P. Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women. Fertil Steril 2013;99:1944-1950.
    • (2013) Fertil Steril , vol.99 , pp. 1944-1950
    • Freour, T.1    Dessolle, L.2    Lammers, J.3    Lattes, S.4    Barrière, P.5
  • 29
    • 0034045087 scopus 로고    scopus 로고
    • Blastocyst score affects implantation and pregnancy outcome: Towards a single blastocyst transfer
    • Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: Towards a single blastocyst transfer. Fertil Steril 2000;73:1155-1158.
    • (2000) Fertil Steril , vol.73 , pp. 1155-1158
    • Gardner, D.K.1    Lane, M.2    Stevens, J.3    Schlenker, T.4    Schoolcraft, W.B.5
  • 31
    • 0142243214 scopus 로고    scopus 로고
    • Assessment of embryo viability: The ability to select a single embryo for transfer
    • Gardner DK, Sakkas D. Assessment of embryo viability: The ability to select a single embryo for transfer. Placenta 2003;24:S5-S12.
    • (2003) Placenta , vol.24 , pp. S5-S12
    • Gardner, D.K.1    Sakkas, D.2
  • 33
    • 84976528281 scopus 로고    scopus 로고
    • Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates. A randomized controlled trial
    • Goodman LR, Goldberg J, Falcone T, Austin C, Desai N. Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates A randomized controlled trial. Fertil Steril 2016;105:275-285.
    • (2016) Fertil Steril , vol.105 , pp. 275-285
    • Goodman, L.R.1    Goldberg, J.2    Falcone, T.3    Austin, C.4    Desai, N.5
  • 34
    • 0003562954 scopus 로고    scopus 로고
    • A simple generalisation of the area under the ROC curve for multiple class classification problems
    • Hand DJ, Till RJ. A simple generalisation of the area under the ROC curve for multiple class classification problems. Mach Learn 2001;45: 171-186.
    • (2001) Mach Learn , vol.45 , pp. 171-186
    • Hand, D.J.1    Till, R.J.2
  • 35
    • 0002294347 scopus 로고
    • A simple sequentially rejective multiple test procedure
    • Holm S. A simple sequentially rejective multiple test procedure. Scand Stat Theory Appl 1979;6:65-70.
    • (1979) Scand Stat Theory Appl , vol.6 , pp. 65-70
    • Holm, S.1
  • 36
    • 84906057896 scopus 로고    scopus 로고
    • Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: A critical review
    • Kaser DJ, Racowsky C. Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: A critical review. Hum Reprod Update 2014;20:617-631.
    • (2014) Hum Reprod Update , vol.20 , pp. 617-631
    • Kaser, D.J.1    Racowsky, C.2
  • 38
    • 84875227619 scopus 로고    scopus 로고
    • Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring
    • Kirkegaard K, Hindkjaer JJ, Ingerslev HJ. Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring. Fertil Steril 2013;99:738-744.
    • (2013) Fertil Steril , vol.99 , pp. 738-744
    • Kirkegaard, K.1    Hindkjaer, J.J.2    Ingerslev, H.J.3
  • 39
    • 83755205798 scopus 로고    scopus 로고
    • Human embryonic development after blastomere removal: A time-lapse analysis
    • Kirkegaard K, Hindkjaer JJ, Ingerslev HJ. Human embryonic development after blastomere removal: A time-lapse analysis. Hum Reprod 2012;27: 97-105.
    • (2012) Hum Reprod , vol.27 , pp. 97-105
    • Kirkegaard, K.1    Hindkjaer, J.J.2    Ingerslev, H.J.3
  • 40
    • 52049089697 scopus 로고    scopus 로고
    • Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes
    • Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod BioMed Online 2008;17:385-391.
    • (2008) Reprod BioMed Online , vol.17 , pp. 385-391
    • Lemmen, J.G.1    Agerholm, I.2    Ziebe, S.3
  • 41
    • 84959271106 scopus 로고    scopus 로고
    • Time-lapse deselection model for human day 3 in vitro fertilization embryos: The combination of qualitative and quantitative measures of embryo growth
    • Liu Y, Chapple V, Feenan K, Roberts P, Matson P. Time-lapse deselection model for human day 3 in vitro fertilization embryos: The combination of qualitative and quantitative measures of embryo growth. Fertil Steril 2016;105:656-662.
    • (2016) Fertil Steril , vol.105 , pp. 656-662
    • Liu, Y.1    Chapple, V.2    Feenan, K.3    Roberts, P.4    Matson, P.5
  • 42
    • 84922056900 scopus 로고    scopus 로고
    • The prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the EmbryoScope time-lapse video system
    • Liu Y, Chapple V, Roberts P, Matson P. The prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the EmbryoScope time-lapse video system. Fertil Steril 2014;102:1295-1302.
    • (2014) Fertil Steril , vol.102 , pp. 1295-1302
    • Liu, Y.1    Chapple, V.2    Roberts, P.3    Matson, P.4
  • 44
    • 84870362736 scopus 로고    scopus 로고
    • Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: A retrospective cohort study
    • Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A. Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: A retrospective cohort study. Fertil Steril 2012;98:1481-1489.
    • (2012) Fertil Steril , vol.98 , pp. 1481-1489
    • Meseguer, M.1    Rubio, I.2    Cruz, M.3    Basile, N.4    Marcos, J.5    Requena, A.6
  • 45
    • 84940363631 scopus 로고    scopus 로고
    • A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development
    • Milewski R, Ku P, Kuczyska A, Stankiewicz B, ukaszuk K, Kuczyski W. A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development. J Assist Reprod Genet 2015;32:571-579.
    • (2015) J Assist Reprod Genet , vol.32 , pp. 571-579
    • Milewski, R.1    Ku, P.2    Kuczyska, A.3    Stankiewicz, B.4    Ukaszuk, K.5    Kuczyski, W.6
  • 46
    • 0035152148 scopus 로고    scopus 로고
    • Evaluation of pronuclear morphology as the only selection criterion for further embryo culture and transfer: Results of a prospective multicentre study
    • Montag M, van der Ven H. Evaluation of pronuclear morphology as the only selection criterion for further embryo culture and transfer: results of a prospective multicentre study. Hum Reprod 2001;16: 2384-2389.
    • (2001) Hum Reprod , vol.16 , pp. 2384-2389
    • Montag, M.1    Van Der Ven, H.2
  • 47
    • 84976592005 scopus 로고    scopus 로고
    • Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system
    • Motato Y, de Los Santos M, Escriba M, Ruiz BA, Remohí J, Meseguer M. Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system. Fertil Steril 2016;105:376-384.
    • (2016) Fertil Steril , vol.105 , pp. 376-384
    • Motato, Y.1    De Los Santos, M.2    Escriba, M.3    Ruiz, B.A.4    Remohí, J.5    Meseguer, M.6
  • 48
    • 0030966854 scopus 로고    scopus 로고
    • Nonparametric Analysis of Clustered ROC Curve Data
    • Obuchowski NA. Nonparametric Analysis of Clustered ROC Curve Data. Biometrics 1997;53:567-578.
    • (1997) Biometrics , vol.53 , pp. 567-578
    • Obuchowski, N.A.1
  • 49
    • 0030965102 scopus 로고    scopus 로고
    • Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography
    • Payne D, Flaherty SP, Barry MF, Matthews CD. Preliminary observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse video cinematography. Hum Reprod 1997;12:532-541.
    • (1997) Hum Reprod , vol.12 , pp. 532-541
    • Payne, D.1    Flaherty, S.P.2    Barry, M.F.3    Matthews, C.D.4
  • 51
    • 84964927929 scopus 로고    scopus 로고
    • R Core Team, R Foundation for Statistical Computing, Vienna, Austria
    • R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2015. URL https://www. R-project. org/.
    • (2015) R: A Language and Environment for Statistical Computing
  • 52
    • 84922125470 scopus 로고    scopus 로고
    • Clinical validation of embryo culture and selection by morphokinetic analysis: A randomized, controlled trial of the EmbryoScope
    • Rubio I, Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, Meseguer M. Clinical validation of embryo culture and selection by morphokinetic analysis: A randomized, controlled trial of the EmbryoScope. Fertil Steril 2014;102:1287-1294.
    • (2014) Fertil Steril , vol.102 , pp. 1287-1294
    • Rubio, I.1    Galán, A.2    Larreategui, Z.3    Ayerdi, F.4    Bellver, J.5    Herrero, J.6    Meseguer, M.7
  • 54
    • 0035195237 scopus 로고    scopus 로고
    • Assessment of early cleaving in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection
    • Sakkas D, Percival G, D'Arcy Y, Sharif K, Afnan M. Assessment of early cleaving in vitro fertilized human embryos at the 2-cell stage before transfer improves embryo selection. Fertil Steril 2001;76:1150-1156.
    • (2001) Fertil Steril , vol.76 , pp. 1150-1156
    • Sakkas, D.1    Percival, G.2    D'Arcy, Y.3    Sharif, K.4    Afnan, M.5
  • 55
    • 0037385701 scopus 로고    scopus 로고
    • Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures
    • Salumets A, Hyden-Granskog C, Makinen S, Suikkari AM, Tiitinen A, Tuuri T. Early cleavage predicts the viability of human embryos in elective single embryo transfer procedures. Hum Reprod 2003;18:821-825.
    • (2003) Hum Reprod , vol.18 , pp. 821-825
    • Salumets, A.1    Hyden-Granskog, C.2    Makinen, S.3    Suikkari, A.M.4    Tiitinen, A.5    Tuuri, T.6
  • 56
    • 0033763216 scopus 로고    scopus 로고
    • The morphology of human pronuclear embryos is positively related to blastocyst development and implantation
    • Scott L, Alvero R, Leondires M, Miller B. The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod 2000;15:2394-2403.
    • (2000) Hum Reprod , vol.15 , pp. 2394-2403
    • Scott, L.1    Alvero, R.2    Leondires, M.3    Miller, B.4
  • 57
    • 33845629889 scopus 로고    scopus 로고
    • Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: Prospective and applied data for increased pregnancy rates
    • Scott L, Finn A, O'Leary T, McLellan S, Hill J. Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates. Hum Reprod 2007;22:230-240.
    • (2007) Hum Reprod , vol.22 , pp. 230-240
    • Scott, L.1    Finn, A.2    O'Leary, T.3    McLellan, S.4    Hill, J.5
  • 58
    • 0031811313 scopus 로고    scopus 로고
    • The successful use of pronuclear embryo transfers the day following oocyte retrieval
    • Scott LA, Smith S. The successful use of pronuclear embryo transfers the day following oocyte retrieval. Hum Reprod 1998;13:1003-1013.
    • (1998) Hum Reprod , vol.13 , pp. 1003-1013
    • Scott, L.A.1    Smith, S.2
  • 59
  • 60
    • 0032905398 scopus 로고    scopus 로고
    • The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology
    • Tesarik J, Greco E. The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology. Hum Reprod 1999;14:318-323.
    • (1999) Hum Reprod , vol.14 , pp. 318-323
    • Tesarik, J.1    Greco, E.2
  • 64
    • 84958045864 scopus 로고    scopus 로고
    • A comprehensive review of the adverse effects of chemical and physical factors on mammalian embryos and their importance for the practice of human assisted reproductive technology
    • Wale P, Gardner DK. A comprehensive review of the adverse effects of chemical and physical factors on mammalian embryos and their importance for the practice of human assisted reproductive technology. Hum Reprod Update 2016;22:2-22.
    • (2016) Hum Reprod Update , vol.22 , pp. 2-22
    • Wale, P.1    Gardner, D.K.2
  • 65
    • 77957840829 scopus 로고    scopus 로고
    • Time-lapse analysis of mouse embryo development in oxygen gradients
    • Wale P, Gardner DK. Time-lapse analysis of mouse embryo development in oxygen gradients. Reprod BioMed Online 2010;21:402-410.
    • (2010) Reprod BioMed Online , vol.21 , pp. 402-410
    • Wale, P.1    Gardner, D.K.2
  • 66
    • 77957938684 scopus 로고    scopus 로고
    • Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
    • Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, Reijo Pera RA. Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nat Biotechnol 2010;28:1115-1121.
    • (2010) Nat Biotechnol , vol.28 , pp. 1115-1121
    • Wong, C.C.1    Loewke, K.E.2    Bossert, N.L.3    Behr, B.4    De Jonge, C.J.5    Baer, T.M.6    Reijo Pera, R.A.7
  • 67
    • 84908298037 scopus 로고    scopus 로고
    • Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting
    • Yalçnkaya E, Ergin EG, Çalkan E, Öztel Z, Özay A, Özörnek H. Reproducibility of a time-lapse embryo selection model based on morphokinetic data in a sequential culture media setting. J Turk Ger Gynecol Assoc 2014;15:156-160.
    • (2014) J Turk Ger Gynecol Assoc , vol.15 , pp. 156-160
    • Yalçnkaya, E.1    Ergin, E.G.2    Çalkan, E.3    Öztel, Z.4    Özay, A.5    Özörnek, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.