Clinical validation of embryo culture and selection by morphokinetic analysis: A randomized, controlled trial of the EmbryoScope

Fertility and Sterility

Volumn 102, Issue 5, 2014, Pages 1287-1294.e5

  Rubio, Irene ^a   Galán, Arancha ^a   Larreategui, Zaloa ^b   Ayerdi, Fernando ^b   Bellver, Jose ^a   Herrero, Javier ^a   Meseguer, Marcos ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b IVI Bilbao   (Spain)

Author keywords

Early pregnancy loss; Embryo culture; Embryo selection; Implantation; Ongoing pregnancy rate; Time lapse

Indexed keywords

PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN;

ABORTION; ADULT; AMNIOSCOPE; AMNIOSCOPY; ARTICLE; BODY MASS; CLINICAL FEATURE; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EMBRYO; EMBRYO CULTURE; EMBRYO TRANSFER; EXPERIMENTAL STUDY; FEMALE; FERTILIZATION IN VITRO; FETUS MONITORING; FIRST TRIMESTER PREGNANCY; GESTATIONAL SAC; HUMAN; HUMAN CELL; IN VITRO SELECTION; INCUBATOR; INTRACYTOPLASMIC SPERM INJECTION; KINETICS; MAJOR CLINICAL STUDY; MORPHOKINETIC ANALYSIS; MORPHOLOGY; MULTICENTER STUDY; NIDATION; OOCYTE DONATION; PREGNANCY OUTCOME; PREGNANCY RATE; PRENATAL CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TIME LAPSE IMAGING; TIME LAPSE MONITORING SYSTEM; TREATMENT OUTCOME; VALIDATION STUDY; ADOLESCENT; ANIMAL EMBRYO; CYTOLOGY; DEVICE FAILURE ANALYSIS; DEVICES; EQUIPMENT DESIGN; INFERTILITY, FEMALE; PATHOLOGY; PREGNANCY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VIDEO MICROSCOPY; YOUNG ADULT;

ADOLESCENT; ADULT; EMBRYO CULTURE TECHNIQUES; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEMALE; FETOSCOPES; HUMANS; INCUBATORS; INFERTILITY, FEMALE; MICROSCOPY, VIDEO; PREGNANCY; PREGNANCY OUTCOME; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME-LAPSE IMAGING; YOUNG ADULT;

EID: 84922125470     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.07.738     Document Type: Article

References (31)

1. Scott L. The biological basis of non-invasive strategies for selection of human oocytes and embryos. Hum Reprod Update 2003;9:237-49.
2. ALPHA Scientists In Reproductive MedicineESHRE Special Interest Group Embryology. Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Reprod Biomed Online 2011;22:632-46.
3. Aparicio B, Cruz M, Meseguer M. Is morphokinetic analysis the answer? Reprod Biomed Online 2013;27:654-63.
4. Kirkegaard K, Agerholm IE, Ingerslev HJ. Time-lapse monitoring as a tool for clinical embryo assessment. Hum Reprod 2012;27:1277-85.
5. Herrero J, Meseguer M. Selection of high potential embryos using time-lapse imaging: the era of morphokinetics. Fertil Steril 2013;99:1030-4.
6. Sundvall L, Ingerslev HJ, Knudsen UB, Kirkegaard K. Inter- and intra-observer variability of time-lapse annotations Hum. Reprod 2013;28:3215-21.
7. Cruz M, Gadea B, Garrido N, Pedersen KS, Martínez M, Pérez-Cano I, et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J Assist Reprod Genet 2011;28:569-73.
8. Meseguer M, Herrero J, Tejera A, Hilligsøe KM, Ramsing NB, Remohí J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod 2011;26:2658-71.
9. Meseguer M, Rubio I, Cruz M, Basile N, Marcos J, Requena A. Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome compared with a standard incubator: a retrospective cohort study. Fertil Steril 2012;98:1481-9.
10. Garrido N, Zuzuarregui JL, Meseguer M, Simón C, Remohí J, Pellicer A. Sperm and oocyte donor selection and management: experience of a 10 year follow-up of more than 2100 candidates. Hum Reprod 2002;17:3142-8.
11. Meseguer M, Santiso R, Garrido N, García-Herrero S, Remohí J, Fernández JL. Effect of sperm DNA fragmentation on pregnancy outcome depends on oocyte quality. Fertil Steril 2010;95:124-8.
12. Melo M, Busso CE, Bellver J, Alama P, Garrido N, Meseguer M, et al. GnRH agonist versus recombinant hCG in an oocyte donation programme: a randomized, prospective, controlled, assessor-blind study. Reprod Biomed Online 2009;19:486-92.
13. Cobo A, Kuwayama M, Pérez S, Ruiz A, Pellicer A, Remohí J. Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method. Fertil Steril 2008;89:1657-64.
14. Meseguer M, Martinez-Conejero JA, O'Connor JE, Pellicer A, Remohi J, Garrido N. The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor. Fertil Steril 2008;89:1191-9.
15. Gamiz P, Rubio C, de los Santos MJ, Mercader A, Simon C, Remohi J, et al. The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos. Hum Reprod 2003;18:2413-9.
16. Bellver J, Ayllon Y, Ferrando M, Melo M, Goyri E, Pellicer A, et al. Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil Steril 2010;93:447-54.
17. Meseguer M, de los Santos MJ, Simon C, Pellicer A, Remohi J, Garrido N. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertil Steril 2006;86:1376-85.
18. deMouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, et al. Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod 2010;25:1851-62.
19. Kirkegaard K, Hindkjaer JJ, Grøndahl ML, Kesmodel US, Ingerslev HJ. A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator. J Assist Reprod Genet 2012;29:565-72.
20. Nakahara T, Iwase A, Goto M, Harata T, Suzuki M, Ienaga M, et al. Evaluation of the safety of time-lapse observations for human embryos. J Assist Reprod Genet 2010;27:93-6.
21. Pribensky C, Matyas S, Kovacs P, Losomczi E, Zadori J, Vajta G. Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring. Reprod Biomed Online 2010;21:533-6.
22. Wong C, Loewke K, Bosser NL, Behr B, De Jonge CJ, Baer TM, et al. Noninvasive imaging of human embryos before embryonic genome activation predicts development to blastocyst stage. Nat Biotechnol 2010;28:1115-21.
23. Dal Canto M, Coticcio G, Renzini M, De Ponti E, Novara PV, Brambillasca F, et al. Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation. Reprod Biomed Online 2012;25:474-80.
24. Campbell A, Fishel S, Bowman N, Duffy S, Sedler M, Fontes CF. Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics. Reprod Biomed Online 2013;26:477-85.
25. Conaghan J, Chen AA, Willman SP, Ivani K, Chenette PE, Boostanfar R, et al. Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial. Fertil Steril 2013;100:412-9.
26. Bontekoe S, Mantikou E, van Wely M, Seshadri S, Repping S, Mastenbroek S. Low oxygen concentrations for embryo culture in assisted reproductive technologies. Cochrane Database Syst Rev 2012:CD008950.
27. Kirkegaard K, Kesmodel US, Hindkjaer JJ, Ingerslev HJ. Time-lapse parameters as predictor of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort study. Hum Reprod 2013;28:2643-51.
28. Wolff HS, Fredrickson JR, Walker DL, Morbeck DE. Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress. Hum Reprod 2013;28:1776-82.
29. Kirkegaard K, Hindkjaer JJ, Ingerslev HJ. Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring. Fertil Steril 2013;99:738-44.
30. Ciray HN, Aksoy T, Goktas C, Ozturk B, Bahceci M. Time-lapse evaluation of human embryo development in single versus sequential culture media-a sibling oocyte study. J Assist Reprod Genet 2012;29:891-900.
31. Fréour T, Dessolle L, Lammers J, Lattes S, Barrière P. Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women. Fertil Steril 2013;99:1944-50.