Frequency of embryo multinucleation detected by time-lapse system and its impact on pregnancy outcome

Fertility and Sterility

Volumn 102, Issue 4, 2014, Pages 1029-1033.e1

  Ergin, Elif G ^a   Çalişkan, Eray ^a   Yalçinkaya, Ender ^a   Öztel, Zeynep ^a   Çökelez, Kevser ^a   Özay, Alev ^a   Özörnek, Hakan M ^a  

^a Eurofertil IVF Center   (Turkey)

Author keywords

Embryo development; morphokinetic; multinucleation; pregnancy rate; time lapse

Indexed keywords

ADULT; AGE; ARTICLE; CONSENSUS; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO MULTINUCLEATION; EMBRYO RESEARCH; FEMALE; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; MALE; MORPHOGENESIS; NIDATION; OOCYTE RETRIEVAL; PREDICTIVE VALUE; PREGNANCY OUTCOME; PREGNANCY RATE; RETROSPECTIVE STUDY; TIME LAPSE IMAGING; ANIMAL EMBRYO; CELL NUCLEUS; CHI SQUARE DISTRIBUTION; EMBRYO CULTURE; EMBRYO TRANSFER; INFERTILITY THERAPY; MATERNAL AGE; PATHOLOGY; PREGNANCY; RISK; RISK FACTOR; STATISTICAL MODEL; TIME; TREATMENT OUTCOME;

ADULT; CELL NUCLEUS; CHI-SQUARE DISTRIBUTION; EMBRYO CULTURE TECHNIQUES; EMBRYO IMPLANTATION; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FEMALE; HUMANS; LOGISTIC MODELS; MATERNAL AGE; ODDS RATIO; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY OUTCOME; REPRODUCTIVE TECHNIQUES, ASSISTED; RETROSPECTIVE STUDIES; RISK FACTORS; SPERM INJECTIONS, INTRACYTOPLASMIC; TIME FACTORS; TIME-LAPSE IMAGING; TREATMENT OUTCOME;

EID: 84908245362     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.06.030     Document Type: Article

References (29)

1. D.K. Gardner, M. Lane, J. Stevens, and W.B. Schoolcraft Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential Fertil Steril 76 2001 1175 1180
2. E. Seli, D. Sakkas, R. Scott, S.C. Kwok, S.M. Rosendahl, and D.H. Burns Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization Fertil Steril 88 2007 1350 1357
3. D. Sakkas, and D.K. Gardner Noninvasive methods to assess embryo quality Curr Opin Obstet Gynecol 17 2005 283 288
4. M.G. Katz-Jaffe, and D.K. Gardner How proteomics can assist in shaping the future of human assisted conception Reprod Biomed Online 17 2008 497 501
5. R. Machtinger, and C. Racowsky Morphological systems of human embryo assessment and clinical evidence Reprod Biomed Online 26 2013 210 221
6. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group Embryology Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting Reprod Biomed Online 22 2011 632 646
7. D.K. Gardner, M. Lane, J. Stevens, T. Schlenker, and W.B. Schoolcraft Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer Fertil Steril 73 2000 1155 1158
8. M. Cruz, N. Garrido, J. Herrero, I. Pérez-Cano, M. Muñoz, and M. Meseguer Timing of cell division in human cleavage stage embryos is linked with blastocyst formation and quality Reprod Biomed Online 25 2012 371 381
9. L. Sundvall, H.J. Ingerslev, U.B. Knudsen, and K. Kirkegaard Inter- and intra-observer variability of time-lapse annotations Hum Reprod 28 2013 3215 3221
10. J. Ambroggio, P.R. Gindoff, M. Dayal, R. Khaldi, D. Peak, and D. Frankfurter Multinucleation of a sibling blastomere on day 2 suggests unsuitability for embryo transfer in IVF-preimplantation genetic screening cycles Fertil Steril 96 2011 856 859
11. K. YakIn, B. Balaban, and B. Urman Impact of the presence of one or more multinucleated blastomeres on the developmental potential of the embryo to the blastocyst stage Fertil Steril 83 2005 243 245
12. A. Azzarello, T. Hoest, and A.L. Mikkelsen The impact of time-lapse assessment on nuclearity: is multinucleation a proper character for embryo selection Hum Reprod 27 Suppl 2 2012 O-268
13. I. Klingman, C. Benadiva, M. Alikani, and S. Munne The presence of multinucleated blastomeres in human embryos is correlated with chrosomal abnormalities Hum Reprod 11 1996 1492 1498
14. E. Van Royen, K. Mangelschots, M. Vercruyssen, D. De Neubourg, M. Valkenburg, and G. Ryckaert Multinucleation in cleavage stage embryos Hum Reprod 18 2003 1062 1069
15. J. Meriano, C. Clark, K. Cadesky, and C.A. Laskin Binucleated and micronucleated blastomeres in embryos derived from human assisted reproduction cycles RBM Online 9 2004 511 520
16. S. Munne Chromosome abnormalities and their relationship to morphology and development of human embryos RBM Online 12 2006 234 253
17. J. Holte, L. Berglund, K. Milton, C. Garrello, G. Gennarelli, and A. Revelli Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval Hum Reprod 22 2007 548 557
18. M. Alikani, G. Calderon, G. Tomkin, J. Garrisi, M. Kokot, and J. Cohen Cleavage anomalies in early human embryos and survival after prolonged culture in-vitro Hum Reprod 15 2000 2634 2643
19. L. Rienzi Significance of morphological attributes of the early embryo RBM Online 5 2005 669 681
20. S. De Vincentiis, E. De Martino, M.G. Buffone, and S. Brugo-Olmedo Use of methaphase I oocytes matured in vitro is associated with embryo multinucleation Fertil Steril 99 2003 414 420
21. D. Nogueira, C. Staessen, H. Van de Velde, and A. Van Steirteghem Nuclear status and cytogenetics of embryos derived from in vitro-matured oocytes Fertil Steril 74 2000 295 298
22. H. Balakier, A. Sojecki, G. Motamedi, and C. Librach Time-dependent capability of human oocytes for activation and pronuclear formation during metaphase II arrest Hum Reprod 19 2004 982 987
23. J. Van Blerkom, M. Antczak, and R. Schrader The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics Hum Reprod 12 1997 1047 1055
24. T. Hardarson, C. Hanson, A. Sjögren, and K. Lundin Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation Hum Reprod 16 2001 313 318
25. S. Munne, and J. Cohen Chromosome abnormalities in human embryos Hum Reprod Update 4 1998 842 855
26. H. Balakier, and K. Cadesky The frequency and developmental capability of human embryos containing multinucleated blastomeres Hum Reprod 12 1997 800 804
27. P. Fauque, E. Audureau, R. Leandri, L. Delaroche, S. Assouline, and S. Epelboin Is the nuclear status of an embryo an independent factor to predict its ability to develop to term? Fertil Steril 99 2013 1299 1304
28. C. Hnidia, I. Agerholm, and S. Ziebe Traditional detection versus computer-controlled multilevel analysis of nuclear structures from donated human embryos Hum Reprod 20 2005 665 671
29. M. Meseguer, J. Herrero, A. Tejera, K.M. Hiligsoe, N.B. Ramsing, and J. Remohi The use of morphokinetics as a predictor of embryo implantation Hum Reprod 26 2011 2658 2671