Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points

Journal of Assisted Reproduction and Genetics

Volumn 32, Issue 1, 2015, Pages 27-35

  Cetinkaya, Murat ^a   Pirkevi, Caroline ^a   Yelke, Hakan ^a   Colakoglu, Yesim Kumtepe ^a   Atayurt, Zafer ^a   Kahraman, Semra ^a  

^a MEMORIAL HOSPITAL   (Turkey)

Author keywords

Blastocyst; Cleavage; Morphokinetics; Synchronicity; Time lapse imaging

Indexed keywords

ARTICLE; BLASTOCYST; CELL DIVISION; CELL KINETICS; CELL STRUCTURE; CELLULAR PARAMETERS; COHORT ANALYSIS; EMBRYO; EMBRYO CLEAVAGE SYNCHRONICITY; EMBRYO CULTURE; FEMALE; FEMALE INFERTILITY; HUMAN; MAJOR CLINICAL STUDY; MORPHOKINETICS; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TIME LAPSE IMAGING; ADULT; EMBRYO DEVELOPMENT; EMBRYO TRANSFER; INFERTILITY; MALE; NIDATION; PATHOLOGY; PHYSIOLOGY; PREGNANCY; PREGNANCY RATE; ULTRASTRUCTURE;

ADULT; BLASTOCYST; EMBRYO IMPLANTATION; EMBRYO TRANSFER; EMBRYONIC DEVELOPMENT; FEMALE; HUMANS; INFERTILITY; MALE; PREGNANCY; PREGNANCY RATE; TIME-LAPSE IMAGING;

EID: 84922074403     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-014-0341-x     Document Type: Article

References (33)

1. Haouzi D, Dechaud H, Assou S, De Vos J, Hamamah S. Insights into human endometrial receptivity from transcriptomic and proteomic data. Reprod Biomed Online. 2012;24:23–4.
2. Gardner DK, Vella P, Lane M, Wagley L, Schlenker T, Schoolcraft WB. Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers. Fertil Steril. 1998;69:84–8.
3. Milki AA, Hinckley MD, Fisch JD, Dasig D, Behr B. Comparison of blastocyst transfer with day 3 embryo transfer in similar patient populations. Fertil Steril. 2000;73:126–9.
4. Kuwayama M, Vajta G, Ieda S, Kato O. Comparison of open and closed methods for vitrification of human embryos and the elimination of potential contamination. Reprod Biomed Online. 2005;11:608–14.
5. Liebermann J. Vitrification of human blastocysts: an update. Reprod Biomed Online. 2009;19 Suppl 4:105–14.
6. Glujovsky D, Blake D, Farquhar C, Bardach A. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2012; doi: 10.1002/14651858.CD002118.pub4
7. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment. Proc Expert Meet Hum Reprod. 2011;26:1270–83.
8. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment. Proc Expert Meet Hum Reprod. 2011;22:632–46.
9. Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril. 2007;88:1350–7.
10. Seli E, Robert C, Sirard MA. OMICS in assisted reproduction: possibilities and pitfalls. Mol Hum Reprod. 2010;16:513–30.
11. Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Ferti Steril. 2008;90:77–83.
12. Scott L, Berntsen J, Davies D, Gundersen J, Hill J, Ramsing N. Symposium: innovative techniques in human embryo viability assessment. Human oocyte respiration-rate measurement—potential to improve oocyte and embryo selection? Reprod Biomed Online. 2008;17:461–9.
13. Lemmen JG, Agerholm I, Ziebe S. Kinetic markers of human embryo quality using time-lapse recordings of IVF/ICSI-fertilized oocytes. Reprod Biomed Online. 2008;17:385–91.
14. Pribensky C, Matyas S, Kovacs P, Losomczi E, Zadori J, Vajta G. Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring. Reprod Biomed Online. 2010;21:533–6.
15. Wong CC, Loewke KE, Bossert NL, Behr B, De Jonge CJ, Baer TM, et al. Non-invasive imaging of human embryos before embryonic genome activation predicts development to blastocyst stage. Nat Biotechnol. 2010;28:1115–21.
16. Kirkegaard K, Agerholm IE, Ingerslev HJ. Time-lapse monitoring as a tool for clinical embryo assessment. Hum Reprod. 2012;27:1277–85.
17. Meseguer M, Herrero J, Tejera A, Hilligsoe KM, Ramsing NB, Remohi J. The use of morphokinetics as a predictor of embryo implantation. Hum Reprod. 2011;26:2658–71.
18. Cruz M, Gadea B, Garrido N, Pedersen KS, Martinez M, Perez-Cano I, et al. Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging. J Assist Reprod Genet. 2011;28:569–73.
19. Kirkegaard K, Hindkjaer JJ, Grøndahl ML, Kesmodel US, Ingerslev HJ. A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator. J Assist Reprod Genet. 2012;29:565–72.
20. Cruz M, Garrido N, Herrero J, Pérez-Cano I, Muñoz M, Meseguer M. Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality. Reprod Biomed Online. 2012;25:371–81.
21. Dal Canto M, Coticchio G, Renzini M, De Ponti E, Novara PV, Brambillasca F, et al. Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation. Reprod Biomed Online. 2012;25:474–80.
22. Conaghan J, Chen AA, Willman SP, Ivani K, Chenette PE, Boostanfar R, et al. Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial. Fertil Steril. 2013;100:412–9.
23. Kirkegaard K, Kesmodel US, Hindkjær JJ, Ingerslev HJ. Time-lapse parameters as predictors of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort study. Hum Reprod. 2013;28:2643–51.
24. Gardner DK, Wale PL, Collins R, Lane M. Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome. Hum Reprod. 2012;26:1981–6.
25. Tejera A, Herrero J, Viloria T, Romero JL, Gamiz P, Meseguer M. Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos. Fertil Steril. 2012;98:849–57.
26. Ciray HN, Aksoy T, Goktas C, Ozturk B, Bahceci M. Time-lapse evaluation of human embryo development in single versus sequential culture media–a sibling oocyte study. J Assist Reprod Genet. 2012;29:891–900.
27. Kirkegaard K, Hindkjaer JJ, Ingerslev HJ. Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring. Fertil Steril. 2013;99:738–44.
28. Muñoz M, Cruz M, Humaidan P, Garrido N, Pérez-Cano I, Meseguer M. The type of GnRH analogue used during controlled ovarian stimulation influences early embryo developmental kinetics: a time-lapse study. Eur J Obstet Gynecol Reprod Biol. 2013;168:167–72.
29. Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18:3769–78.
30. Kalra SK, Ratcliffe SJ, Barnhart KT, Coutifaris C. Extended embryo culture and an increased risk of preterm delivery. Obstet Gynecol. 2012;120:69–75.
31. Campbell A, Fishel S, Bowman N, Duffy S, Sedler M, Hickman CF. Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics. Reprod Biomed Online. 2013;26:477–85.
32. Campbell A, Fishel S, Bowman N, Duffy S, Sedler M, Thornton S. Retrospective analysis of outcomes after IVF using an aneuploidy risk model derived from time-lapse imaging without PGS. Reprod Biomed Online. 2013;27:140–6.
33. Kirkegaard K, Campbell A, Agerholm I, Bentin-Ley U, Gabrielsen A, Kirk J, Sayed S, Ingerslev HJ. Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis. 2014; doi: 10.1016/j.rbmo.2014.04.011