Activation of the Wnt/β-catenin pathway in pancreatic beta cells during the compensatory islet hyperplasia in prediabetic mice

Biochemical and Biophysical Research Communications

Volumn 478, Issue 4, 2016, Pages 1534-1540

  Maschio, D A ^a   Oliveira, R B ^a   Santos, M R ^a   Carvalho, C P F ^b   Barbosa Sampaio, H C L ^a   Collares Buzato, C B ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Compensatory beta cell hyperplasia; Prediabetes; Wnt catenin pathway

Indexed keywords

BETA CATENIN; CYCLIN D1; CYCLIN D2; MYC PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PRIORITY JOURNAL; PROTEIN CONTENT; WNT SIGNALING PATHWAY; ANIMAL; C57BL MOUSE; CELL SIZE; HYPERPLASIA; METABOLISM; PATHOLOGY;

ANIMALS; CELL SIZE; DIET, HIGH-FAT; HYPERPLASIA; INSULIN-SECRETING CELLS; MALE; MICE, INBRED C57BL; PREDIABETIC STATE; WNT SIGNALING PATHWAY;

EID: 84992146562     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.08.146     Document Type: Article

References (39)

1. [1] Collares-Buzato, C.B., High-fat diets and β-cell dysfunction: molecular aspects. Mauricio, D., (eds.) Molecular Nutrition and Diabetes, 2015, Elsevier/Academic Press, San Diego, 115–130.
2. [2] Lee, Y.C., Nielsen, J.H., Regulation of beta cell replication. Mol. Cell. Endocrinol. 297 (2009), 18–27.
3. [3] Prentki, M., Nolan, C.J., Islet beta cell failure in type 2 diabetes. J. Clin. Investig. 116 (2006), 1802–1812.
4. [4] Oliveira, R.B., Maschio, D.A., Carvalho, C.P.F., Collares-Buzato, C.B., Influence of gender and time diet exposure on endocrine pancreas remodeling in response to high fat diet-induced metabolic disturbances in mice. Ann. Anat. 200 (2015), 88–97.
5. [5] Li, Q., Lail, Z.-Q., Recent progress in studies of factors that elicit pancreatic β-cell expansion. Protein Cell 6 (2015), 81–87.
6. [6] Montanya, E., Insulin resistance compensation: not just a matter of beta-cells?. Diabetes 63 (2014), 832–834.
7. [7] Jin, T., The WNT signalling pathway and diabetes mellitus. Diabetologia 51 (2008), 1771–1780.
8. [8] Murtaugh, L.C., The what, where, when and how of Wnt/beta-catenin signaling in pancreas development. Organogenesis 4 (2008), 81–86.
9. [9] MacDonald, B.T., Tamai, K., He, X., Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17 (2009), 9–26.
10. [10] Welters, H.J., Kulkarni, R.N., Wnt signalling: relevance to β-cell biology and diabetes. Trends Endocrinol. Metab. 19 (2008), 349–355.
11. [11] Gui, S., Yuan, G., Wang, L., et al. Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling. J. Cell. Biochem. 114 (2013), 1488–1497.
12. [12] Rulifson, I.C., Karnik, S.K., Heiser, P.W., et al. Wnt signaling regulated pancreatic beta cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 6247–6252.
13. [13] Schinner, S., Ülgen, F., Papewalis, C., et al. Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51 (2008), 147–154.
14. [14] Boj, S.F., van El, J.H., Huch, M., et al. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 151 (2012), 1595–1607.
15. [15] Figeac, F.B.U., Faro, M., Chelali, N., et al. Neonatal growth and regeneration of β-cells are regulated by the Wnt/β-catenin signaling in normal and diabetic rats. Am. J. Physiol. Endocrinol. Metabol. 298 (2009), 245–256.
16. [16] Mitchell, R.K., Mondragon, A., Chen, L., et al. Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum. Mol. Genet. 5 (2015), 1390–1399.
17. [17] Oliveira, R.B., Carvalho, C.P.F., Polo, C.C., et al. Impaired compensatory beta-cell function and growth in response to high-fat diet in LDL receptor knockout mice. Int. J. Exp. Path 95 (2014), 296–308.
18. [18] Carvalho, C.P.F., Martins, J.C., da Cunha, D.A., et al. Histomorphology and ultrastructure of pancreatic islet tissue during in vivo maturation of rat pancreas. Ann. Anat. 188 (2006), 221–234.
19. [19] Carvalho, C.P.F., Oliveira, R.B., Britan, A., et al. Impaired β-cell-β-cell coupling mediated by Cx36 gap junctions in prediabetic mice. Am. J. Physiol. Endocrinol. Metab. 303 (2012), 144–151.
20. [20] Falcão, V.T.F.L., Maschio, D.A., de Fontes, C.C., et al. Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules in diabetic mice after prolonged high fat diet. Histochem. Cell. Biol. 146 (2016), 13–31.
21. [21] Bustin, S.A., Benes, V., Garson, J.A., et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55 (2009), 611–622.
22. [22] Lee, J., Kim, K., Yu, S.W., Kim, E.-K., Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus. Mol. Brain 9 (2016), 1–24.
23. [23] Sone, H., Kagawa, Y., Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice. Diabetol 48 (2005), 58–67.
24. [24] Liew, C.G., Andrews, P.W., Stem cell therapy to treat diabetes mellitus. Rev Diabet. Stud. 5 (2008), 203–219.
25. [25] Kahn, S.E., Hull, R.L., Utzschneider, K.M., Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 14 (2006), 840–846.
26. [26] Tomita, T., Apoptosis in pancreatic β-islet cells in type 2 diabetes. Bosn. J. Basic Med. 3 (2016), 162–179.
27. [27] Clevers, H., Wnt/beta-catenin signaling in development and disease. Cell 127 (2006), 469–480.
28. [28] Hu, B.R., Fairey, A.S., Madhav, A., et al. AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth. Prostate 76 (2016), 597–608.
29. [29] Fujino, T., Asabab, H., Kang, M.J., et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U. S. A. 100 (2003), 229–234.
30. [30] Elghazi, L., Gould, A.P., Weiss, A.J., et al. Importance of β-Catenin in glucose and energy homeostasis. Sci. Rep., 2, 2012, 693.
31. [31] McCarthy, M.I., Rorsman, P., Gloyn, A.L., TCF7L2 and diabetes: a tale of two tissues, and of two species. Cell Metabol. 17 (2013), 157–159.
32. [32] Liu, Z., Habener, J.F., Wnt signaling in pancreatic islets. Islam, M.S., (eds.) The Islets of Langerhans, vol. 654, 2010, Springer, New York, 391–419.
33. [33] Teitelman, G., Kedees, M., Mouse insulin cells expressing an inducible RIPCre transgene are functionally impaired. J. Biol. Chem. 290 (2015), 3647–3653.
34. [34] Chen, H.-Z., Liu, Q.-F., Li, L., et al. The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signaling. Gut 61 (2012), 714–724.
35. [35] Hou, N., Ye, B., Li, X., et al. Transcription Factor 7-like 2 mediates canonical Wnt/β-catenin signaling and c-Myc upregulation in heart failure. Circ. Heart Fail., 9, 2016 pii: e003010. doi: 10.1161/CIRCHEARTFAILURE.116.003010.
36. [36] Shi, Q., Luo, S., Jia, H., Wnt/β-catenin signaling may be involved with the maturation, but not the differentiation, of insulin-producing cells. Biomed. Pharmacother. 67 (2013), 745–750.
37. [37] Zhang, J., Shemezis, J.R., McQuinn, E.R., et al. AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development. Neural Dev. 8 (2013), 7–23 http://www.neuraldevelopment.com/content/8/1/7.
38. [38] Liu, Z., Habener, J.F., Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J. Biol. Chem. 283 (2008), 8723–8735.
39. [39] Columbus, J., Chiang, Y., Shao, W., et al. Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas. J. Endocrinol. 207 (2010), 77–86.