Mouse insulin cells expressing an inducible RIPCre transgene are functionally impaired

Journal of Biological Chemistry

Volumn 290, Issue 6, 2015, Pages 3647-3653

  Teitelman, Gladys ^a   Kedees, Mamdouh ^a  

^a Downstate Health Sciences University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INSULIN;

BETA CELL; GENE FUNCTION; TRANSGENE;

CYTOLOGY;

ALKALINE PHOSPHATASE PLACENTA ISOENZYME; CRE RECOMBINASE; DIPEPTIDYL PEPTIDASE IV; DNA; ENHANCED YELLOW FLUORESCENT PROTEIN; ESTROGEN RECEPTOR; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; PROTEIN; TAMOXIFEN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; DPP4 PROTEIN, MOUSE; GLP1R PROTEIN, MOUSE; GLP1R PROTEIN, RAT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON RECEPTOR; GREEN FLUORESCENT PROTEIN; INTEGRASE; PEPTIDE; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; VENOM;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS BY BODY ANATOMY; CONTROLLED STUDY; DNA RECOMBINATION; GENE EXPRESSION; GENE FUNCTION; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMMUNOCYTOCHEMISTRY; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; TRANSGENIC MOUSE; ANIMAL; DRUG EFFECTS; GENETICS; GLUCOSE INTOLERANCE; METABOLISM; PHENOTYPE; PHYSIOLOGY; PROMOTER REGION; REPORTER GENE;

ANIMALS; CELL PROLIFERATION; DIPEPTIDYL PEPTIDASE 4; GENES, REPORTER; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE INTOLERANCE; GREEN FLUORESCENT PROTEINS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; INTEGRASES; MICE; PEPTIDES; PHENOTYPE; PROMOTER REGIONS, GENETIC; PROTEASE INHIBITORS; RECEPTORS, ESTROGEN; RECEPTORS, GLUCAGON; RECOMBINANT PROTEINS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; VENOMS;

EID: 84922344426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.615484     Document Type: Article

References (30)

1. Lee, J. Y., Ristow, M., Lin, X., White, M. F., Magnuson, M. A., and Hennighausen, L. (2006) RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J. Biol. Chem. 281, 2649-2653
2. Wicksteed, B., Brissova, M., Yan, W., Opland, D. M., Plank, J. L., Reinert, R. B., Dickson, L. M., Tamarina, N. A., Philipson, L. H., Shostak, A., Bernal-Mizrachi, E., Elghazi, L., Roe, M. W., Labosky, P. A., Myers, M. G., Jr., Gannon, M., Powers, A. C., and Dempsey, P. J. (2010) Conditional Gene Targeting in Mouse Pancreatic {beta}-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain. Diabetes 59, 3090-3098
3. Harno, E., Cottrell, E. C., and White, A. (2013) Metabolic pitfalls of CNS Cre-based technology. Cell Metab. 18, 21-28
4. Schmidt-Supprian, M., and Rajewsky, K. (2007) Vagaries of conditional gene targeting. Nat. Immunol. 8, 665-668
5. Göke, R., Fehmann, H. C., Linn, T., Schmidt, H., Krause, M., Eng, J., and Göke, B. (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells. J. Biol. Chem. 268, 19650-19655
6. Drucker, D. J. (2006) The biology of incretin hormones. Cell Metab. 3, 153-165
7. Holst, J. J., and Deacon, C. F. (2005) Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 48, 612-615
8. Liu, H., Guz, Y., Kedees, M. H., Winkler, J., and Teitelman, G. (2010) Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology 151, 520-528
9. Grigoryan, M., Kedees, M. H., Charron, M. J., Guz, Y., and Teitelman, G. (2012) Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides. Endocrinology 153, 3076-3088
10. Mu, J., Woods, J., Zhou, Y. P., Roy, R. S., Li, Z., Zycband, E., Feng, Y., Zhu, L., Li, C., Howard, A. D., Moller, D. E., Thornberry, N. A., and Zhang, B. B. (2006) Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 55, 1695-1704
11. Hellestrom, C., and Swenne, I. (1985) Growth pattern of pancreatic islet cells in animals in The Diabetic Pancreas. 2nd Ed. (Volk, B., and Arquilla, E., eds), pp. 53-80, Plenum Medical Book Co, New York and London
12. Lee, K. Y., Russell, S. J., Ussar, S., Boucher, J., Vernochet, C., Mori, M. A., Smyth, G., Rourk, M., Cederquist, C., Rosen, E. D., Kahn, B. B., and Kahn, C. R. (2013) Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 62, 864-874
13. Young, A. A., Gedulin, B. R., Bhavsar, S., Bodkin, N., Jodka, C., Hansen, B., and Denaro, M. (1999) Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48, 1026-1034
14. Ellenbroek, J. H., Töns, H. A., Westerouen van Meeteren, M. J., de Graaf, N., Hanegraaf, M. A., Rabelink, T. J., Carlotti, F., and de Koning, E. J. (2013) Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice. Diabetologia 56, 1980-1986
15. Gao, T., McKenna, B., Li, C., Reichert, M., Nguyen, J., Singh, T., Yang, C., Pannikar, A., Doliba, N., Zhang, T., Stoffers, D. A., Edlund, H., Matschinsky, F., Stein, R., and Stanger, B. Z. (2014) Pdx1 maintains beta cell identity and function by repressing an alpha cell program. Cell Metab. 19, 259-271
16. Talchai, C., Xuan, S., Lin, H. V., Sussel, L., and Accili, D. (2012) Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150, 1223-1234
17. Weinberg, N., Ouziel-Yahalom, L., Knoller, S., Efrat, S., and Dor, Y. (2007) Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes 56, 1299-1304
18. Brennand, K., Huangfu, D., and Melton, D. (2007) All beta Cells Contribute Equally to Islet Growth and Maintenance. PLoS Biol. 5, e163
19. Tang, T., Abbott, M. J., Ahmadian, M., Lopes, A. B., Wang, Y., and Sul, H. S. (2013) Desnutrin/ATGL activates PPAR to promote mitochondrial function for insulin secretion in islet beta cells. Cell Metab. 18, 883-895
20. Beall, C., Piipari, K., Al-Qassab, H., Smith, M. A., Parker, N., Carling, D., Viollet, B., Withers, D. J., and Ashford, M. L. (2010) Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem. J. 429, 323-333
21. Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis II, Dace, W., Mattis, K. K., Ramracheya, R., Gribble, F. M., Reimann, F., Clark, A., Rorsman, P., and Ashcroft, F. M. (2014) Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nat. Commun. 5, 4639
22. Abouna, S., Old, R. W., Pelengaris, S., Epstein, D., Ifandi, V., Sweeney, I., and Khan, M. (2010) Non-beta-cell progenitors of beta-cells in pregnant mice. Organogenesis 6, 125-133
23. Zeng, N., Yang, K. T., Bayan, J. A., He, L., Aggarwal, R., Stiles, J. W., Hou, X., Medina, V., Abad, D., Palian, B. M., Al-Abdullah, I., Kandeel, F., Johnson, D. L., and Stiles, B. L. (2013) PTEN controls beta-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell 12, 1000-1011
24. Yang, K. T., Bayan, J. A., Zeng, N., Aggarwal, R., He, L., Peng, Z., Kassa, A., Kim, M., Luo, Z., Shi, Z., Medina, V., Boddupally, K., and Stiles, B. L. (2014) Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia 57, 352-361
25. Rankin, M. M., Wilbur, C. J., Rak, K., Shields, E. J., Granger, A., and Kushner, J. A. (2013) beta-Cells are not generated in pancreatic duct ligationinduced injury in adult mice. Diabetes 62, 1634-1645
26. Carrington, E. M., McKenzie, M. D., Jansen, E., Myers, M., Fynch, S., Kos, C., Strasser, A., Kay, T. W., Scott, C. L., and Allison, J. (2009) Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes 58, 2316-2323
27. Gu, C., Stein, G. H., Pan, N., Goebbels, S., Hörnberg, H., Nave, K. A., Herrera, P., White, P., Kaestner, K. H., Sussel, L., and Lee, J. E. (2010) Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 11, 298-310
28. Herrera, P. L. (2000) Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Development 127, 2317-2322
29. Tamarina, N. A., Roe, M. W., and Philipson, L. (2014) Characterization of mice expressing Ins1 gene promoter driven CreERT recombinase for conditional gene deletion in pancreatic beta-cells. Islets 6, 27685
30. Magnuson, M. A., and Osipovich, A. B. (2013) Pancreas-specific Cre driver lines and considerations for their prudent use. Cell Metab. 18, 9-20