메뉴 건너뛰기




Volumn 95, Issue 12, 2016, Pages 1333-1340

Microenvironmental views on mesenchymal stem cell differentiation in aging

Author keywords

age factors; mesenchymal stromal cells; microenvironment; osteogenesis; rejuvenation; stem cell niche

Indexed keywords

AGING; ANIMAL; CELL DIFFERENTIATION; HUMAN; MESENCHYMAL STROMA CELL; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

EID: 84992088244     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034516653589     Document Type: Review
Times cited : (82)

References (60)
  • 1
    • 33744782285 scopus 로고    scopus 로고
    • Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females
    • Abdallah BM, Haack-Sorensen M, Fink T, Kassem M., 2006. Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged females. Bone. 39 (1): 181-188.
    • (2006) Bone , vol.39 , Issue.1 , pp. 181-188
    • Abdallah, B.M.1    Haack-Sorensen, M.2    Fink, T.3    Kassem, M.4
  • 2
  • 3
    • 84881661464 scopus 로고    scopus 로고
    • The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer
    • Anisimov VN, Bartke A., 2013. The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer. Crit Rev Oncol Hematol. 87 (3): 201-223.
    • (2013) Crit Rev Oncol Hematol , vol.87 , Issue.3 , pp. 201-223
    • Anisimov, V.N.1    Bartke, A.2
  • 4
    • 84942294112 scopus 로고    scopus 로고
    • Epigenetic regulation of ageing: Linking environmental inputs to genomic stability
    • Benayoun BA, Pollina EA, Brunet A., 2015. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 16 (10): 593-610.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , Issue.10 , pp. 593-610
    • Benayoun, B.A.1    Pollina, E.A.2    Brunet, A.3
  • 5
    • 33845883071 scopus 로고    scopus 로고
    • Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice
    • Botolin S, McCabe LR,. 2007. Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endocrinology. 148 (1): 198-205.
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 198-205
    • Botolin, S.1    McCabe, L.R.2
  • 6
    • 84866437496 scopus 로고    scopus 로고
    • Aging effect on neurotrophic activity of human mesenchymal stem cells
    • Brohlin M, Kingham PJ, Novikova LN, Novikov LN, Wiberg M., 2012. Aging effect on neurotrophic activity of human mesenchymal stem cells. PLoS One. 7 (9): e45052.
    • (2012) PLoS One , vol.7 , Issue.9 , pp. e45052
    • Brohlin, M.1    Kingham, P.J.2    Novikova, L.N.3    Novikov, L.N.4    Wiberg, M.5
  • 7
    • 49249086654 scopus 로고    scopus 로고
    • Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells
    • Chen CT, Shih YR, Kuo TK, Lee OK, Wei YH,. 2008. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells. 26 (4): 960-968.
    • (2008) Stem Cells , vol.26 , Issue.4 , pp. 960-968
    • Chen, C.T.1    Shih, Y.R.2    Kuo, T.K.3    Lee, O.K.4    Wei, Y.H.5
  • 8
    • 84875969826 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates osteogenesis of periodontal ligament stem cells through competition with beta-catenin signaling in inflammatory microenvironments
    • Chen X, Hu C, Wang G, Li L, Kong X, Ding Y, Jin Y., 2013. Nuclear factor-kappaB modulates osteogenesis of periodontal ligament stem cells through competition with beta-catenin signaling in inflammatory microenvironments. Cell Death Dis. 4: e510.
    • (2013) Cell Death Dis , vol.4 , pp. e510
    • Chen, X.1    Hu, C.2    Wang, G.3    Li, L.4    Kong, X.5    Ding, Y.6    Jin, Y.7
  • 9
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo BJ, Korach KS,. 2006. Estrogen receptors and human disease. J Clin Invest. 116 (3): 561-570.
    • (2006) J Clin Invest , vol.116 , Issue.3 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 10
    • 84866507629 scopus 로고    scopus 로고
    • Prevalence of periodontitis in adults in the United States: 2009 and 2010
    • CDC Periodontal Disease Surveillance Workgroup
    • Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ, CDC Periodontal Disease Surveillance Workgroup. 2012. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 91 (10): 914-920.
    • (2012) J Dent Res , vol.91 , Issue.10 , pp. 914-920
    • Eke, P.I.1    Dye, B.A.2    Wei, L.3    Thornton-Evans, G.O.4    Genco, R.J.5
  • 11
    • 71349086901 scopus 로고    scopus 로고
    • Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    • Elbaz A, Rivas D, Duque G., 2009. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice. Biogerontology. 10 (6): 747-755.
    • (2009) Biogerontology , vol.10 , Issue.6 , pp. 747-755
    • Elbaz, A.1    Rivas, D.2    Duque, G.3
  • 12
    • 84858700225 scopus 로고    scopus 로고
    • The role of estrogen deficiency in skin ageing and wound healing
    • Emmerson E, Hardman MJ,. 2012. The role of estrogen deficiency in skin ageing and wound healing. Biogerontology. 13 (1): 3-20.
    • (2012) Biogerontology , vol.13 , Issue.1 , pp. 3-20
    • Emmerson, E.1    Hardman, M.J.2
  • 13
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span: From yeast to humans
    • Fontana L, Partridge L, Longo VD,. 2010. Extending healthy life span: from yeast to humans. Science. 328 (5976): 321-326.
    • (2010) Science , vol.328 , Issue.5976 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 15
    • 84921026457 scopus 로고    scopus 로고
    • Dose-response estrogen promotes osteogenic differentiation via GPR40 (FFAR1) in murine BMMSCs
    • Gao B, Huang Q, Jie Q, Wang L, Zhang HY, Liu J, Yang L, Luo ZJ,. 2015. Dose-response estrogen promotes osteogenic differentiation via GPR40 (FFAR1) in murine BMMSCs. Biochimie. 110: 36-44.
    • (2015) Biochimie , vol.110 , pp. 36-44
    • Gao, B.1    Huang, Q.2    Jie, Q.3    Wang, L.4    Zhang, H.Y.5    Liu, J.6    Yang, L.7    Luo, Z.J.8
  • 16
    • 84871705613 scopus 로고    scopus 로고
    • Functional comparison of chronological and in vitro aging: Differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells
    • Geissler S, Textor M, Kuhnisch J, Konnig D, Klein O, Ode A, Pfitzner T, Adjaye J, Kasper G, Duda GN,. 2012. Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells. PLoS One. 7 (12): e52700.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. e52700
    • Geissler, S.1    Textor, M.2    Kuhnisch, J.3    Konnig, D.4    Klein, O.5    Ode, A.6    Pfitzner, T.7    Adjaye, J.8    Kasper, G.9    Duda, G.N.10
  • 17
    • 84891819452 scopus 로고    scopus 로고
    • In serum veritas-in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway
    • Geissler S, Textor M, Schmidt-Bleek K, Klein O, Thiele M, Ellinghaus A, Jacobi D, Ode A, Perka C, Dienelt A, et al. 2013. In serum veritas-in serum sanitas? Cell non-autonomous aging compromises differentiation and survival of mesenchymal stromal cells via the oxidative stress pathway. Cell Death Dis. 4: e970.
    • (2013) Cell Death Dis , vol.4 , pp. e970
    • Geissler, S.1    Textor, M.2    Schmidt-Bleek, K.3    Klein, O.4    Thiele, M.5    Ellinghaus, A.6    Jacobi, D.7    Ode, A.8    Perka, C.9    Dienelt, A.10
  • 18
    • 79951610661 scopus 로고    scopus 로고
    • Inflammation and uncoupling as mechanisms of periodontal bone loss
    • Graves DT, Li J, Cochran DL,. 2011. Inflammation and uncoupling as mechanisms of periodontal bone loss. J Dent Res. 90 (2): 143-153.
    • (2011) J Dent Res , vol.90 , Issue.2 , pp. 143-153
    • Graves, D.T.1    Li, J.2    Cochran, D.L.3
  • 19
    • 70350230373 scopus 로고    scopus 로고
    • Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells
    • Guan CC, Yan M, Jiang XQ, Zhang P, Zhang XL, Li J, Ye DX, Zhang FQ,. 2009. Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells. Bone. 45 (6): 1146-1152.
    • (2009) Bone , vol.45 , Issue.6 , pp. 1146-1152
    • Guan, C.C.1    Yan, M.2    Jiang, X.Q.3    Zhang, P.4    Zhang, X.L.5    Li, J.6    Ye, D.X.7    Zhang, F.Q.8
  • 20
    • 84859822387 scopus 로고    scopus 로고
    • OXPHOS supercomplexes as a hallmark of the mitochondrial phenotype of adipogenic differentiated human MSCs
    • Hofmann AD, Beyer M, Krause-Buchholz U, Wobus M, Bornhäuser M, Rödel G., 2012. OXPHOS supercomplexes as a hallmark of the mitochondrial phenotype of adipogenic differentiated human MSCs. PLoS One. 7 (4): e35160.
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e35160
    • Hofmann, A.D.1    Beyer, M.2    Krause-Buchholz, U.3    Wobus, M.4    Bornhäuser, M.5    Rödel, G.6
  • 21
    • 84959534327 scopus 로고    scopus 로고
    • Suppression of EZH2 prevents the shift of osteoporotic MSC fate to adipocyte and enhances bone formation during osteoporosis
    • Jing H, Liao L, An Y, Su X, Liu S, Shuai Y, Zhang X, Jin Y., 2016. Suppression of EZH2 prevents the shift of osteoporotic MSC fate to adipocyte and enhances bone formation during osteoporosis. Mol Ther. 24 (2): 217-229.
    • (2016) Mol Ther , vol.24 , Issue.2 , pp. 217-229
    • Jing, H.1    Liao, L.2    An, Y.3    Su, X.4    Liu, S.5    Shuai, Y.6    Zhang, X.7    Jin, Y.8
  • 22
    • 84924247757 scopus 로고    scopus 로고
    • Mesenchymal cell contributions to the stem cell niche
    • Kfoury Y, Scadden DT,. 2015. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell. 16 (3): 239-253.
    • (2015) Cell Stem Cell , vol.16 , Issue.3 , pp. 239-253
    • Kfoury, Y.1    Scadden, D.T.2
  • 23
    • 84881504150 scopus 로고    scopus 로고
    • GSK3beta is a checkpoint for TNF-alpha-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments
    • Kong X, Liu Y, Ye R, Zhu B, Zhu Y, Liu X, Hu C, Luo H, Zhang Y, Ding Y, et al. 2013. GSK3beta is a checkpoint for TNF-alpha-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments. Biochim Biophys Acta. 1830 (11): 5119-5129.
    • (2013) Biochim Biophys Acta , vol.1830 , Issue.11 , pp. 5119-5129
    • Kong, X.1    Liu, Y.2    Ye, R.3    Zhu, B.4    Zhu, Y.5    Liu, X.6    Hu, C.7    Luo, H.8    Zhang, Y.9    Ding, Y.10
  • 24
    • 24144449526 scopus 로고    scopus 로고
    • Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone
    • Kume S, Kato S, Yamagishi S, Inagaki Y, Ueda S, Arima N, Okawa T, Kojiro M, Nagata K., 2005. Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J Bone Miner Res. 20 (9): 1647-1658.
    • (2005) J Bone Miner Res , vol.20 , Issue.9 , pp. 1647-1658
    • Kume, S.1    Kato, S.2    Yamagishi, S.3    Inagaki, Y.4    Ueda, S.5    Arima, N.6    Okawa, T.7    Kojiro, M.8    Nagata, K.9
  • 25
    • 33749510640 scopus 로고    scopus 로고
    • Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts
    • Leskela HV, Olkku A, Lehtonen S, Mahonen A, Koivunen J, Turpeinen M, Uusitalo J, Pelkonen O, Kangas L, Selander K, et al. 2006. Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts. Bone. 39 (5): 1026-1034.
    • (2006) Bone , vol.39 , Issue.5 , pp. 1026-1034
    • Leskela, H.V.1    Olkku, A.2    Lehtonen, S.3    Mahonen, A.4    Koivunen, J.5    Turpeinen, M.6    Uusitalo, J.7    Pelkonen, O.8    Kangas, L.9    Selander, K.10
  • 27
    • 84954306743 scopus 로고    scopus 로고
    • TNF-alpha inhibits FoxO1 by up-regulating miR-705 to aggravate oxidative damage in bone marrow-derived mesenchymal stem cells during osteoporosis
    • Liao L, Su X, Yang X, Hu C, Li B, Lv Y, Shuai Y, Jing H, Deng Z, Jin Y., 2015. TNF-alpha inhibits FoxO1 by up-regulating miR-705 to aggravate oxidative damage in bone marrow-derived mesenchymal stem cells during osteoporosis. Stem Cells. 34 (4): 1054-1067.
    • (2015) Stem Cells , vol.34 , Issue.4 , pp. 1054-1067
    • Liao, L.1    Su, X.2    Yang, X.3    Hu, C.4    Li, B.5    Lv, Y.6    Shuai, Y.7    Jing, H.8    Deng, Z.9    Jin, Y.10
  • 28
    • 84876928351 scopus 로고    scopus 로고
    • Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow
    • Liao L, Yang X, Su X, Hu C, Zhu X, Yang N, Chen X, Shi S, Shi S, Jin Y., 2013. Redundant miR-3077-5p and miR-705 mediate the shift of mesenchymal stem cell lineage commitment to adipocyte in osteoporosis bone marrow. Cell Death Dis. 4: e600.
    • (2013) Cell Death Dis , vol.4 , pp. e600
    • Liao, L.1    Yang, X.2    Su, X.3    Hu, C.4    Zhu, X.5    Yang, N.6    Chen, X.7    Shi, S.8    Shi, S.9    Jin, Y.10
  • 29
    • 80051981178 scopus 로고    scopus 로고
    • High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway
    • Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, et al. 2011. High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway. J Bone Miner Res. 26 (9): 2082-2095.
    • (2011) J Bone Miner Res , vol.26 , Issue.9 , pp. 2082-2095
    • Liu, N.1    Shi, S.2    Deng, M.3    Tang, L.4    Zhang, G.5    Liu, N.6    Ding, B.7    Liu, W.8    Liu, Y.9    Shi, H.10
  • 30
    • 84939561073 scopus 로고    scopus 로고
    • DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis
    • Liu Q, Hu CH, Zhou CH, Cui XX, Yang K, Deng C, Xia JJ, Wu Y, Liu LC, Jin Y., 2015. DKK1 rescues osteogenic differentiation of mesenchymal stem cells isolated from periodontal ligaments of patients with diabetes mellitus induced periodontitis. Sci Rep. 5: 13142.
    • (2015) Sci Rep , vol.5 , pp. 13142
    • Liu, Q.1    Hu, C.H.2    Zhou, C.H.3    Cui, X.X.4    Yang, K.5    Deng, C.6    Xia, J.J.7    Wu, Y.8    Liu, L.C.9    Jin, Y.10
  • 31
    • 84943429397 scopus 로고    scopus 로고
    • MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in lupus
    • Liu S, Liu D, Chen C, Hamamura K, Moshaverinia A, Yang R, Liu Y, Jin Y, Shi S., 2015. MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in lupus. Cell Metab. 22 (4): 606-618.
    • (2015) Cell Metab , vol.22 , Issue.4 , pp. 606-618
    • Liu, S.1    Liu, D.2    Chen, C.3    Hamamura, K.4    Moshaverinia, A.5    Yang, R.6    Liu, Y.7    Jin, Y.8    Shi, S.9
  • 32
    • 84890955970 scopus 로고    scopus 로고
    • Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions
    • Liu W, Konermann A, Guo T, Jager A, Zhang L, Jin Y., 2014. Canonical Wnt signaling differently modulates osteogenic differentiation of mesenchymal stem cells derived from bone marrow and from periodontal ligament under inflammatory conditions. Biochim Biophys Acta. 1840 (3): 1125-1134.
    • (2014) Biochim Biophys Acta , vol.1840 , Issue.3 , pp. 1125-1134
    • Liu, W.1    Konermann, A.2    Guo, T.3    Jager, A.4    Zhang, L.5    Jin, Y.6
  • 33
    • 80051718140 scopus 로고    scopus 로고
    • Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells
    • Lo T, Ho JH, Yang MH, Lee OK,. 2011. Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells. Cell Transplant. 20 (6): 813-825.
    • (2011) Cell Transplant , vol.20 , Issue.6 , pp. 813-825
    • Lo, T.1    Ho, J.H.2    Yang, M.H.3    Lee, O.K.4
  • 34
    • 0027469006 scopus 로고
    • Periodontal disease: The sixth complication of diabetes mellitus
    • Loe H,. 1993. Periodontal disease: the sixth complication of diabetes mellitus. Diabetes Care. 16 (1): 329-334.
    • (1993) Diabetes Care , vol.16 , Issue.1 , pp. 329-334
    • Loe, H.1
  • 35
    • 84947795226 scopus 로고    scopus 로고
    • Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass
    • Ming L, Jin F, Huang P, Luo H, Liu W, Zhang L, Yuan W, Zhang Y, Jin Y., 2014. Licochalcone A up-regulates of FasL in mesenchymal stem cells to strengthen bone formation and increase bone mass. Sci Rep. 4: 7209.
    • (2014) Sci Rep , vol.4 , pp. 7209
    • Ming, L.1    Jin, F.2    Huang, P.3    Luo, H.4    Liu, W.5    Zhang, L.6    Yuan, W.7    Zhang, Y.8    Jin, Y.9
  • 36
    • 84859941981 scopus 로고    scopus 로고
    • Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice
    • Mirsaidi A, Kleinhans KN, Rimann M, Tiaden AN, Stauber M, Rudolph KL, Richards PJ,. 2012. Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice. J Tissue Eng Regen Med. 6 (5): 378-390.
    • (2012) J Tissue Eng Regen Med , vol.6 , Issue.5 , pp. 378-390
    • Mirsaidi, A.1    Kleinhans, K.N.2    Rimann, M.3    Tiaden, A.N.4    Stauber, M.5    Rudolph, K.L.6    Richards, P.J.7
  • 37
    • 84905741423 scopus 로고    scopus 로고
    • Stem cell aging: Mechanisms, regulators and therapeutic opportunities
    • Oh J, Lee YD, Wagers AJ,. 2014. Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med. 20 (8): 870-880.
    • (2014) Nat Med , vol.20 , Issue.8 , pp. 870-880
    • Oh, J.1    Lee, Y.D.2    Wagers, A.J.3
  • 39
    • 84861210529 scopus 로고    scopus 로고
    • Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development
    • Peltz L, Gomez J, Marquez M, Alencastro F, Atashpanjeh N, Quang T, Bach T, Zhao Y., 2012. Resveratrol exerts dosage and duration dependent effect on human mesenchymal stem cell development. PLoS One. 7 (5): e37162.
    • (2012) PLoS One , vol.7 , Issue.5 , pp. e37162
    • Peltz, L.1    Gomez, J.2    Marquez, M.3    Alencastro, F.4    Atashpanjeh, N.5    Quang, T.6    Bach, T.7    Zhao, Y.8
  • 40
    • 34748892483 scopus 로고    scopus 로고
    • Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: Results from the Stem Cells in Myocardial Infarction (STEMMI) trial
    • (11 Suppl)
    • Ripa RS, Haack-Sorensen M, Wang Y, Jorgensen E, Mortensen S, Bindslev L, Friis T, Kastrup J., 2007. Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial. Circulation. 116 (11 Suppl): I24-I30.
    • (2007) Circulation , vol.116 , pp. I24-I30
    • Ripa, R.S.1    Haack-Sorensen, M.2    Wang, Y.3    Jorgensen, E.4    Mortensen, S.5    Bindslev, L.6    Friis, T.7    Kastrup, J.8
  • 42
    • 84960469542 scopus 로고    scopus 로고
    • Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage
    • Singh L, Brennan TA, Russell E, Kim JH, Chen Q, Brad Johnson F, Pignolo RJ,. 2016. Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage. Bone. 85: 29-36.
    • (2016) Bone , vol.85 , pp. 29-36
    • Singh, L.1    Brennan, T.A.2    Russell, E.3    Kim, J.H.4    Chen, Q.5    Brad Johnson, F.6    Pignolo, R.J.7
  • 43
    • 0035975717 scopus 로고    scopus 로고
    • The process of aging changes the interplay of the immune, endocrine and nervous systems
    • Straub RH, Cutolo M, Zietz B, Scholmerich J., 2001. The process of aging changes the interplay of the immune, endocrine and nervous systems. Mech Ageing Dev. 122 (14): 1591-1611.
    • (2001) Mech Ageing Dev , vol.122 , Issue.14 , pp. 1591-1611
    • Straub, R.H.1    Cutolo, M.2    Zietz, B.3    Scholmerich, J.4
  • 44
    • 84944596591 scopus 로고    scopus 로고
    • Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells
    • Sui B, Hu C, Jin Y., 2015. Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells. Biogerontology. 17 (2): 267-279.
    • (2015) Biogerontology , vol.17 , Issue.2 , pp. 267-279
    • Sui, B.1    Hu, C.2    Jin, Y.3
  • 45
    • 84951914738 scopus 로고    scopus 로고
    • Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass
    • Sun J, Ming L, Shang F, Shen L, Chen J, Jin Y., 2015. Apocynin suppression of NADPH oxidase reverses the aging process in mesenchymal stem cells to promote osteogenesis and increase bone mass. Sci Rep. 5: 18572.
    • (2015) Sci Rep , vol.5 , pp. 18572
    • Sun, J.1    Ming, L.2    Shang, F.3    Shen, L.4    Chen, J.5    Jin, Y.6
  • 46
    • 79955661834 scopus 로고    scopus 로고
    • Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix
    • Sun Y, Li W, Lu Z, Chen R, Ling J, Ran Q, Jilka RL, Chen XD,. 2011. Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix. FASEB J. 25 (5): 1474-1485.
    • (2011) FASEB J , vol.25 , Issue.5 , pp. 1474-1485
    • Sun, Y.1    Li, W.2    Lu, Z.3    Chen, R.4    Ling, J.5    Ran, Q.6    Jilka, R.L.7    Chen, X.D.8
  • 48
    • 84961117284 scopus 로고    scopus 로고
    • Gamma-secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells
    • Tang Z, Wei J, Yu Y, Zhang J, Liu L, Tang W, Long J, Zheng X, Jing W., 2016. Gamma-secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells. Cell Biol Int. 40 (4): 439-447.
    • (2016) Cell Biol Int , vol.40 , Issue.4 , pp. 439-447
    • Tang, Z.1    Wei, J.2    Yu, Y.3    Zhang, J.4    Liu, L.5    Tang, W.6    Long, J.7    Zheng, X.8    Jing, W.9
  • 49
    • 84879911724 scopus 로고    scopus 로고
    • IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling
    • Wang L, Zhao Y, Liu Y, Akiyama K, Chen C, Qu C, Jin Y, Shi S., 2013. IFN-gamma and TNF-alpha synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFkappaB signaling. Stem Cells. 31 (7): 1383-1395.
    • (2013) Stem Cells , vol.31 , Issue.7 , pp. 1383-1395
    • Wang, L.1    Zhao, Y.2    Liu, Y.3    Akiyama, K.4    Chen, C.5    Qu, C.6    Jin, Y.7    Shi, S.8
  • 50
    • 84962221311 scopus 로고    scopus 로고
    • TNF-alpha-induced NF-kappaB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting beta-catenin
    • Wang N, Zhou Z, Wu T, Liu W, Yin P, Pan C, Yu X., 2016. TNF-alpha-induced NF-kappaB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting beta-catenin. Open Biol. 6 (3): 150258.
    • (2016) Open Biol , vol.6 , Issue.3 , pp. 150258
    • Wang, N.1    Zhou, Z.2    Wu, T.3    Liu, W.4    Yin, P.5    Pan, C.6    Yu, X.7
  • 51
    • 84917691109 scopus 로고    scopus 로고
    • MiRNA-130b is required for the ERK/FOXM1 pathway activation-mediated protective effects of isosorbide dinitrate against mesenchymal stem cell senescence induced by high glucose
    • Xu J, Huang Z, Lin L, Fu M, Song Y, Shen Y, Ren D, Gao Y, Su Y, Zou Y, et al. 2015. miRNA-130b is required for the ERK/FOXM1 pathway activation-mediated protective effects of isosorbide dinitrate against mesenchymal stem cell senescence induced by high glucose. Int J Mol Med. 35 (1): 59-71.
    • (2015) Int J Mol Med , vol.35 , Issue.1 , pp. 59-71
    • Xu, J.1    Huang, Z.2    Lin, L.3    Fu, M.4    Song, Y.5    Shen, Y.6    Ren, D.7    Gao, Y.8    Su, Y.9    Zou, Y.10
  • 53
    • 84873944895 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis
    • Yang N, Wang G, Hu C, Shi Y, Liao L, Shi S, Cai Y, Cheng S, Wang X, Liu Y, et al. 2013. Tumor necrosis factor alpha suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency-induced osteoporosis. J Bone Miner Res. 28 (3): 559-573.
    • (2013) J Bone Miner Res , vol.28 , Issue.3 , pp. 559-573
    • Yang, N.1    Wang, G.2    Hu, C.3    Shi, Y.4    Liao, L.5    Shi, S.6    Cai, Y.7    Cheng, S.8    Wang, X.9    Liu, Y.10
  • 54
    • 84971528821 scopus 로고    scopus 로고
    • Leptin receptor promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow
    • Yue R, Zhou BO, Shimada IS, Zhao Z, Morrison SJ., 2016. Leptin receptor promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow. Cell Stem Cell. 18 (6): 782-796.
    • (2016) Cell Stem Cell , vol.18 , Issue.6 , pp. 782-796
    • Yue, R.1    Zhou, B.O.2    Shimada, I.S.3    Zhao, Z.4    Morrison, S.J.5
  • 55
    • 84864316892 scopus 로고    scopus 로고
    • The effect of aging on the pluripotential capacity and regenerative potential of human periodontal ligament stem cells
    • Zhang J, An Y, Gao LN, Zhang YJ, Jin Y, Chen FM,. 2012. The effect of aging on the pluripotential capacity and regenerative potential of human periodontal ligament stem cells. Biomaterials. 33 (29): 6974-6986.
    • (2012) Biomaterials , vol.33 , Issue.29 , pp. 6974-6986
    • Zhang, J.1    An, Y.2    Gao, L.N.3    Zhang, Y.J.4    Jin, Y.5    Chen, F.M.6
  • 56
    • 80053281947 scopus 로고    scopus 로고
    • Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1
    • Zhao L, Huang J, Zhang H, Wang Y, Matesic LE, Takahata M, Awad H, Chen D, Xing L., 2011. Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1. Stem Cells. 29 (10): 1601-1610.
    • (2011) Stem Cells , vol.29 , Issue.10 , pp. 1601-1610
    • Zhao, L.1    Huang, J.2    Zhang, H.3    Wang, Y.4    Matesic, L.E.5    Takahata, M.6    Awad, H.7    Chen, D.8    Xing, L.9
  • 57
    • 70349896340 scopus 로고    scopus 로고
    • Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment
    • Zheng W, Wang S, Ma D, Tang L, Duan Y, Jin Y., 2009. Loss of proliferation and differentiation capacity of aged human periodontal ligament stem cells and rejuvenation by exposure to the young extrinsic environment. Tissue Eng Part A. 15 (9): 2363-2371.
    • (2009) Tissue Eng Part A , vol.15 , Issue.9 , pp. 2363-2371
    • Zheng, W.1    Wang, S.2    Ma, D.3    Tang, L.4    Duan, Y.5    Jin, Y.6
  • 58
    • 84905861462 scopus 로고    scopus 로고
    • Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow
    • Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ,. 2014. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 15 (2): 154-168.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 154-168
    • Zhou, B.O.1    Yue, R.2    Murphy, M.M.3    Peyer, J.G.4    Morrison, S.J.5
  • 59
    • 79955096675 scopus 로고    scopus 로고
    • Role of bone marrow-derived progenitor cells in the maintenance and regeneration of dental mesenchymal tissues
    • Zhou J, Shi S, Shi Y, Xie H, Chen L, He Y, Guo W, Wen L, Jin Y., 2011. Role of bone marrow-derived progenitor cells in the maintenance and regeneration of dental mesenchymal tissues. J Cell Physiol. 226 (8): 2081-2090.
    • (2011) J Cell Physiol , vol.226 , Issue.8 , pp. 2081-2090
    • Zhou, J.1    Shi, S.2    Shi, Y.3    Xie, H.4    Chen, L.5    He, Y.6    Guo, W.7    Wen, L.8    Jin, Y.9
  • 60
    • 84938417942 scopus 로고    scopus 로고
    • Melatonin reverses H2 O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway
    • Zhou L, Chen X, Liu T, Gong Y, Chen S, Pan G, Cui W, Luo ZP, Pei M, Yang H, et al. 2015. Melatonin reverses H2 O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. J Pineal Res. 59 (2): 190-205.
    • (2015) J Pineal Res , vol.59 , Issue.2 , pp. 190-205
    • Zhou, L.1    Chen, X.2    Liu, T.3    Gong, Y.4    Chen, S.5    Pan, G.6    Cui, W.7    Luo, Z.P.8    Pei, M.9    Yang, H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.