Glucose reduction prevents replicative senescence and increases mitochondrial respiration in human mesenchymal stem cells

Cell Transplantation

Volumn 20, Issue 6, 2011, Pages 813-825

  Lo, Ting ^a   Ho, Jennifer H ^b,c   Yang, Muh Hwa ^a,d   Lee, Oscar K ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Glucose reduction; Mesenchymal stem cells (MSCs); Mitochondria; Replicative senescence

Indexed keywords

BETA GALACTOSIDASE; GLUCOSE; PROTEIN P16;

ADIPOCYTE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL AGING; CELL CYCLE; CELL DIFFERENTIATION; CELL ENERGY; CELL LINEAGE; CELL RENEWAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MITOCHONDRIAL RESPIRATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE;

BETA-GALACTOSIDASE; CELL AGING; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; GLUCOSE; HUMANS; LACTIC ACID; MESENCHYMAL STEM CELLS; MITOCHONDRIA; OXYGEN CONSUMPTION;

EID: 80051718140     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X539100     Document Type: Article

References (42)

1. Alcendor R. R.; Gao S.; Zhai P.; Zablocki D.; Holle E.; Yu X.; Tian B.; Wagner T.; Vatner S. F.; Sadoshima J. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100(10):1512-1521; 2007.
2. Barja G. Mitochondrial oxygen consumption and reactive oxygen species production are independently modulated: Implications for aging studies. Rejuvenation Res. 10(2):215-224; 2007.
3. Barros M. H.; Bandy B.; Tahara E. B.; Kowaltowski A. J. Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J. Biol. Chem. 279(48):49883-49888; 2004.
4. Baxter M. A.; Wynn R. F.; Jowitt S. N.; Wraith J. E.; Fairbairn L. J.; Bellantuono I. Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22(5):675-682; 2004.
5. Calabrese E. J.; McCarthy M. E.; Kenyon E. The occurrence of chemically induced hormesis. Health Phys. 52(5):531-541; 1987.
6. Caplan A. I. Mesenchymal stem cells. J. Orthop. Res. 9(5):641-650; 1991.
7. Chen C. T.; Shih Y. R.; Kuo T. K.; Lee O. K.; Wei Y. H. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 26(4):960-968; 2008.
8. Civitarese A. E.; Carling S.; Heilbronn L. K.; Hulver M. H.; Ukropcova B.; Deutsch W. A.; Smith S. R.; Ravussin E. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4(3):e76; 2007.
9. Colman R. J.; Anderson R. M.; Johnson S. C.; Kastman E. K.; Kosmatka K. J.; Beasley T. M.; Allison D. B.; Cruzen C.; Simmons H. A.; Kemnitz J. W.; Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325(5937):201-204; 2009.
10. Dani D.; Shimokawa I.; Komatsu T.; Higami Y.; Warnken U.; Schokraie E.; Schnolzer M.; Krause F.; Sugawa M. D.; Dencher N. A. Modulation of oxidative phosphorylation machinery signifies a prime mode of anti-ageing mechanism of calorie restriction in male rat liver mitochondria. Biogerontology 11(3):321-334, 2010.
11. da Silva Meirelles L.; Chagastelles P. C.; Nardi N. B. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J. Cell Sci. 119(Pt. 11):2204-2213; 2006.
12. Gatenby R. A.; Gillies R. J. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4(11):891-899; 2004.
13. Gems D.; Partridge L. Stress-response hormesis and aging: "That which does not kill us makes us stronger." Cell Metab. 7(3):200-203; 2008.
14. Goldberg A. A.; Bourque S. D.; Kyryakov P.; Gregg C.; Boukh-Viner T.; Beach A.; Burstein M. T.; Machkalyan G.; Richard V.; Rampersad S.; Cyr D.; Milijevic S.; Titorenko V. I. Effect of calorie restriction on the metabolic history of chronologically aging yeast. Exp. Gerontol. 44(9):555-571; 2009.
15. Guarente L. Mitochondria-a nexus for aging, calorie restriction, and sirtuins? Cell 132(2):171-176; 2008.
16. Guppy M.; Greiner E.; Brand K. The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur. J. Biochem. 212(1):95-99; 1993.
17. Howitz K. T.; Bitterman K. J.; Cohen H. Y.; Lamming D. W.; Lavu S.; Wood J. G.; Zipkin R. E.; Chung P.; Kisielewski A.; Zhang L. L.; Scherer B.; Sinclair D. A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954):191-196; 2003.
18. Hu W.; Zhang C.; Wu R.; Sun Y.; Levine A.; Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc. Natl. Acad. Sci. USA 107(16):7455-7460; 2010.
19. INK4a. Nature 443(7110):421-426; 2006.
20. Kaeberlein M.; McVey M.; Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13(19):2570-2580; 1999.
21. Krishnamurthy J.; Torrice C.; Ramsey M. R.; Kovalev G. I.; Al-Regaiey K.; Su L.; Sharpless N. E. Ink4a/Arf expression is a biomarker of aging. J. Clin. Invest. 114(9):1299-1307; 2004.
22. Kuo T. K.; Ho J. H.; Lee O. K. Mesenchymal stem cell therapy for nonmusculoskeletal diseases: Emerging applications. Cell Transplant. 18(9):1013-1028; 2009.
23. Kuo T. K.; Hung S. P.; Chuang C. H.; Chen C. T.; Shih Y. R.; Fang S. C.; Yang V. W.; Lee O. K. Stem cell therapy for liver disease: Parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology 134(7):2111-2121; 2008.
24. Lambert A. J.; Brand M. D. Research on mitochondria and aging, 2006-2007. Aging Cell 6(4):417-420; 2007.
25. Lambert A. J.; Wang B.; Yardley J.; Edwards J.; Merry B. J. The effect of aging and caloric restriction on mitochondrial protein density and oxygen consumption. Exp. Gerontol. 39(3):289-295; 2004.
26. Lee O. K.; Kuo T. K.; Chen W. M.; Lee K. D.; Hsieh S. L.; Chen T. H. Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103(5):1669-1675; 2004.
27. Lopez-Lluch G.; Hunt N.; Jones B.; Zhu M.; Jamieson H.; Hilmer S.; Cascajo M. V.; Allard J.; Ingram D. K.; Navas P.; de Cabo R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA 103(6):1768-1773; 2006.
28. Maklashina E.; Ackrell B. A. Is defective electron transport at the hub of aging? Aging Cell 3(1):21-27; 2004.
29. Ohgushi H.; Kotobuki N.; Funaoka H.; Machida H.; Hirose M.; Tanaka Y.; Takakura Y. Tissue engineered ceramic artificial joint-ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis. Biomaterials 26(22):4654-4661; 2005.
30. Pamplona R.; Barja G. Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity. Ageing Res. Rev. 6(3):189-210; 2007.
31. Pittenger M. F.; Mackay A. M.; Beck S. C.; Jaiswal R. K.; Douglas R.; Mosca J. D.; Moorman M. A.; Simonetti D. W.; Craig S.; Marshak D. R. Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147; 1999.
32. Roth G. S.; Mattison J. A.; Ottinger M. A.; Chachich M. E.; Lane M. A.; Ingram D. K. Aging in rhesus monkeys: Relevance to human health interventions. Science 305(5689):1423-1426; 2004.
33. Salem H. K.; Thiemermann C. Mesenchymal stromal cells: Current understanding and clinical status. Stem Cells 28(3):585-596; 2010.
34. Sandstrom M. E.; Zhang S. J.; Bruton J.; Silva J. P.; Reid M. B.; Westerblad H.; Katz A. Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J. Physiol. 575(Pt. 1):251-262; 2006.
35. Sinclair D. A. Toward a unified theory of caloric restriction and longevity regulation. Mech. Ageing Dev. 126(9):987-1002; 2005.
36. Sreekumar R.; Unnikrishnan J.; Fu A.; Nygren J.; Short K. R.; Schimke J.; Barazzoni R.; Nair K. S. Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle. Am. J. Physiol. Endocrinol. Metab. 283(1):E38-43; 2002.
37. St-Pierre J.; Drori S.; Uldry M.; Silvaggi J. M.; Rhee J.; Jager S.; Handschin C.; Zheng K.; Lin J.; Yang W.; Simon D. K.; Bachoo R.; Spiegelman B. M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127(2):397-408; 2006.
38. Tissenbaum H. A.; Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410(6825):227-230; 2001.
39. Turturro A.; Hass B.; Hart R. W. Hormesis-implications for risk assessment caloric intake (body weight) as an exemplar. Hum. Exp. Toxicol. 17(8):454-459; 1998.
40. Vacanti V.; Kong E.; Suzuki G.; Sato K.; Canty J. M.; Lee T. Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture. J. Cell. Physiol. 205(2):194-201; 2005.
41. Weindruch R. The retardation of aging by caloric restriction: Studies in rodents and primates. Toxicol. Pathol. 24(6):742-745; 1996.
42. Zou X. H.; Cai H. X.; Yin Z.; Chen X.; Jiang Y. Z.; Hu H.; Ouyang H. W. A novel strategy incorporated the power of mesenchymal stem cells to allografts for segmental bone tissue engineering. Cell Transplant. 18(4):433-441; 2009.