Sonic hedgehog alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of bone marrow stromal cells

Bone

Volumn 45, Issue 6, 2009, Pages 1146-1152

  Guan, Cheng chao ^a,b   Yan, Ming ^a   Jiang, Xin quan ^a   Zhang, Ping ^a   Zhang, Xiu li ^a   Li, Jing ^a   Ye, Dong xia ^a   Zhang, Fu qiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow stromal cells; Diabetes; Differentiation; Osteogenesis; Sonic hedgehog

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 4; GLUCOSE; OSTEOPONTIN; PROTEIN PATCHED 1; RECOMBINANT PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; STROMA CELL;

ALKALINE PHOSPHATASE; ANIMALS; ANTHRAQUINONES; BLOTTING, WESTERN; BONE MARROW CELLS; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELLS, CULTURED; CULTURE MEDIA; GENE EXPRESSION REGULATION; GLUCOSE; HEDGEHOG PROTEINS; HUMANS; OSTEOBLASTS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROMAL CELLS;

EID: 70350230373     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.08.009     Document Type: Article

References (39)

1. Gopalakrishnan V., Arunakaran J., Aruldhas M.M., and Srinivasan N. Effects of streptozotocin-induced diabetes mellitus on some bone turnover markers in the vertebrae of ovary-intact and ovariectomized adult rats. Biochem. Cell. Biol. 84 (2006) 728-736
2. Verhaeghe J., Thomsen J.S., van Bree R., van Herck E., Bouillon R., and Mosekilde L. Effects of exercise and disuse on bone remodeling, bone mass, and biomechanical competence in spontaneously diabetic female rats. Bone 27 (2000) 249-256
3. Locatto M.E., Abranzon H., Caferra D., Fernandez M.C., Alloatti R., and Puche R.C. Growth and development of bone mass in untreated alloxan diabetic rats. Effects of collagen glycosylation and parathyroid activity on bone turnover. Bone Miner. 23 (1993) 129-144
4. Kemink S.A., Hermus A.R., Swinkels L.M., Lutterman J.A., and Smals A.G. Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology. J. Endocrinol. Invest. 23 (2000) 295-303
5. Verhaeghe J., Suiker A.M., Iyyomba B.L., et al. Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover and decreased osteocalcin synthesis. Endocrinology 124 (1989) 573-582
6. Lavery L.A., Armstrong D.G., Wunderlich R.P., Tredwell J., and Boulton A.J. Diabetic foot syndrome: evaluating the prevalence and incidence of foot pathology in Mexican Americans and non-Hispanic whites from a diabetes disease management cohort. Diabetes Care 26 (2003) 1435-1438
7. Seino Y., and Ishida H. Diabetic osteopenia: pathophysiology and clinical aspects. Diabetes Metab. Rev. 11 (1995) 21-35
8. Strotmeyer E.S., Cauley J.A., Schwartz A.V., Nevitt M.C., Resnick H.E., Bauer D.C., et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch. Intern. Med. 165 (2005) 1612-1617
9. Agarwala S., Sanders T.A., and Ragsdale C.W. Sonic hedgehog control of size and shape in midbrain pattern formation. Science 291 (2001) 2147-2150
10. Ahlgren S.C., Thakur V., and Bronner-Fraser M. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc. Nat. Acad. Sci. 99 (2002) 10476-10481
11. Ahn S., and Joyner A.L. In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog. Nature 437 (2005) 894-897
12. Chen Y., and Struhl G. Dual roles for Patched in sequestering and transducing Hedgehog. Cell 87 (1996) 553-563
13. Ahlgren S.C., Thakur V., and Bronner-Fraser M. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10476-10481
14. Ahlgren S.C., and Bronner-Fraser M. Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death. Curr. Biol. 9 (1999) 1304-1314
15. Nakamura T., Aikawa T., Iwamoto-Enomoto M., Iwamoto M., Higuchi Y., Pacifici M., et al. Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun. 237 2 (1997) 465-469
16. Ho J.E., Chung E.H., Wall S., Schaffer D.V., and Healy K.E. Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived mesenchymal stem cells. J. Biomed. Mater. Res. A 83 (2007) 1200-1208
17. Edwards P.C., Ruggiero S., Fantasia J., Burakoff R., Moorji S.M., Paric E., et al. Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther. 12 (2005) 75-86
18. Asai J., Takenaka H., Kusano K.F., Ii M., Luedemann C., Curry C., et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 113 (2006) 2413-2424
19. Lopez-Ibarra P.J., Pastor M.M., Escobar-Jimenez F., Pardo M.D., Gonzalez A.G., Luna J.D., et al. Bone mineral density at time of clinical diagnosis of adult-onset type 1 diabetes mellitus. Endocr. Pract. 7 (2001) 346-3451
20. Scott N.S., and Choung C.M. Dual action of sonic hedgehog on chondrocyte hypertrophy: retrovirus mediated ectopic sonic hedgehog expression in limb bud micromass culture induces novel cartilage nodules that are positive for alkaline phosphatase and type X collagen. J. Cell. Sci. 110 (1997) 01-2691
21. Tuominen J.T., Impivaara O., Puukka P., and Ronnemaa T. Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care 22 (1999) 00-1196
22. Hampson G., Evans C., Petitt R.J., Evans W.D., Woodhead S.J., Peters J.R., et al. Bone mineral density, collagen type 1 alpha 1 genotypes and bone turnover in premenopausal women with diabetes mellitus. Diabetologia 41 (1998) 1314-1320
23. Kayath M.J., Dib S.A., and Vieiaa J.G. Prevalence and magnitude of osteopenia associated with insulin-dependent diabetes mellitus. J. Diabetes Complicat. 8 (1994) 97-104
24. Heap J., Murray M.A., Miller S.C., Jalili T., and Moyer-Mileur L.J. Alterations in bone characteristics associated with glycemic control in adolescents with type 1 diabetes mellitus. J. Pediatr. 144 (2004) 56-62
25. Meyer H.E., Tverdal A., and Falch J.A. Risk factors for hip fracture in middle-aged Norwegian women and men. Am. J. Epidemiol. 137 (1993) 1203-1211
26. Bodine P.V.N., Trailsmith M., and Komm B.S. Development and characterization of a conditionally transformed human osteoblatic cell line. J. Bone. Miner. Res. 11 (1996) 806-819
27. Nicodemus K.K., and Folsom A.R. Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. Diabetes Care 24 (2001) 1192-1197
28. Loder R.T. The influence of diabetes mellitus on the healing of closed fractures. Clin. Orthop. Relat. Res. 232 (1988) 210-216
29. Bouillon R. Diabetic bone disease. Calcif. Tissue Int. 49 (1991) 155-160
30. Lu H., Kraut D., Gerstenfeld L.C., and Graves D.T. Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology 144 (2003) 346-3452
31. Jehle P.M., Jehle D.R., Mohan S., and Bohm B.O. Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients. J. Endocrinol. 159 (1998) 06-297
32. Botolin S., and McCabe L.R. Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways. J. Cell. Biochem. 99 (2006) 411-424
33. Shang Q., Wang Z., Liu W., Shi Y., Cui L., and Cao Y. Tissue-engineered bone repair of sheep cranial defects with autologous bone marrow stromal cells. J. Craniofac. Surg. 12 (2001) 586-593
34. Bhardwaj G., Murdoch B., Wu D., Baker D.P., Williams K.P., Chadwick K., et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat. Immunol. 2 (2001) 172-180
35. Shimoyama A., Wada M., Ikeda F., Hata K., Matsubara T., Nifuji A., et al. Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol. Biol. Cell 18 (2007) 2411-2419
36. Lan Y., and Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development 136 (2009) 1387-1396
37. Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Wesphal H., et al. Cyclopia and defective axial patterning in mice lacking sonic hedgehog gene function. Nature 383 (1996) 407-413
38. Hammerschmidt M., Brook A., and McMahon A.P. The world according to hedgehog. Trends Genet. 13 (1997) 14-21
39. Calcutt N.A., Allendoerfer K.L., Mizisin A.P., Middlemas A., Freshwater J.D., Burgers M., et al. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J. Clin. Invest. 111 (2003) 507-514