Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

Journal of Pineal Research

Volumn 59, Issue 2, 2015, Pages 190-205

  Zhou, Long ^a   Chen, Xi ^a   Liu, Tao ^a   Gong, Yihong ^b   Chen, Sijin ^c   Pan, Guoqing ^a   Cui, Wenguo ^a   Luo, Zong Ping ^a   Pei, Ming ^d   Yang, Huilin ^a   He, Fan ^a  

^a SOOCHOW UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

hydrogen peroxide; melatonin; mesenchymal stem cells; senescence; SIRT1

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HYDROGEN PEROXIDE; LUZINDOLE; MELATONIN; MELATONIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR RUNX2; BENZAMIDE DERIVATIVE; NAPHTHOL DERIVATIVE; SIRT1 PROTEIN, HUMAN;

ARTICLE; BONE DEVELOPMENT; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL AGING; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DENSITY; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PHENOTYPE; PREMATURE AGING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; MESENCHYMAL STROMA CELL; METABOLISM;

BENZAMIDES; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; HUMANS; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MELATONIN; MESENCHYMAL STROMAL CELLS; NAPHTHOLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; S PHASE; SIRTUIN 1;

EID: 84938417942     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12250     Document Type: Article

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