-
1
-
-
84856528059
-
The pharmacology of adrenomedullin 2/intermedin
-
Hong, Y., Hay, D. L., Quirion, R., and Poyner, D. R. (2012) The pharmacology of adrenomedullin 2/intermedin. Br. J. Pharmacol. 166, 110-120
-
(2012)
Br. J. Pharmacol.
, vol.166
, pp. 110-120
-
-
Hong, Y.1
Hay, D.L.2
Quirion, R.3
Poyner, D.R.4
-
2
-
-
84921714353
-
Calcitonin gene-related peptide: Physiology and pathophysiology
-
Russell, F. A., King, R., Smillie, S. J., Kodji, X., and Brain, S. D. (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol. Rev. 94, 1099-1142
-
(2014)
Physiol. Rev.
, vol.94
, pp. 1099-1142
-
-
Russell, F.A.1
King, R.2
Smillie, S.J.3
Kodji, X.4
Brain, S.D.5
-
3
-
-
84882577435
-
CGRP receptor antagonism and migraine therapy
-
Edvinsson, L., and Warfvinge, K. (2013) CGRP receptor antagonism and migraine therapy. Curr. Protein Pept. Sci. 14, 386-392
-
(2013)
Curr. Protein Pept. Sci.
, vol.14
, pp. 386-392
-
-
Edvinsson, L.1
Warfvinge, K.2
-
4
-
-
84936802765
-
Bench-to-bedside pharmacology of adrenomedullin
-
Kato, J., and Kitamura, K. (2015) Bench-to-bedside pharmacology of adrenomedullin. Eur. J. Pharmacol. 764, 140-148
-
(2015)
Eur. J. Pharmacol.
, vol.764
, pp. 140-148
-
-
Kato, J.1
Kitamura, K.2
-
5
-
-
38149064606
-
Adrenomedullin signaling is necessary for murine lymphatic vascular development
-
Fritz-Six, K. L., Dunworth, W. P., Li, M., and Caron, K. M. (2008) Adrenomedullin signaling is necessary for murine lymphatic vascular development. J. Clin. Invest. 118, 40-50
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 40-50
-
-
Fritz-Six, K.L.1
Dunworth, W.P.2
Li, M.3
Caron, K.M.4
-
6
-
-
38149140953
-
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity
-
Ichikawa-Shindo, Y., Sakurai, T., Kamiyoshi, A., Kawate, H., Iinuma, N., Yoshizawa, T., Koyama, T., Fukuchi, J., Iimuro, S., Moriyama, N., Kawakami, H., Murata, T., Kangawa, K., Nagai, R., and Shindo, T. (2008) The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J. Clin. Invest. 118, 29-39
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 29-39
-
-
Ichikawa-Shindo, Y.1
Sakurai, T.2
Kamiyoshi, A.3
Kawate, H.4
Iinuma, N.5
Yoshizawa, T.6
Koyama, T.7
Fukuchi, J.8
Iimuro, S.9
Moriyama, N.10
Kawakami, H.11
Murata, T.12
Kangawa, K.13
Nagai, R.14
Shindo, T.15
-
7
-
-
1342346545
-
Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
-
Roh, J., Chang, C. L., Bhalla, A., Klein, C., and Hsu, S. Y. (2004) Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J. Biol. Chem. 279, 7264-7274
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7264-7274
-
-
Roh, J.1
Chang, C.L.2
Bhalla, A.3
Klein, C.4
Hsu, S.Y.5
-
8
-
-
84888223228
-
Protective effects of intermedin on cardiovascular, pulmonary and renal diseases: Comparison with adrenomedullin and CGRP
-
Holmes, D., Campbell, M., Harbinson, M., and Bell, D. (2013) Protective effects of intermedin on cardiovascular, pulmonary and renal diseases: comparison with adrenomedullin and CGRP. Curr. Protein Pept. Sci. 14, 294-329
-
(2013)
Curr. Protein Pept. Sci.
, vol.14
, pp. 294-329
-
-
Holmes, D.1
Campbell, M.2
Harbinson, M.3
Bell, D.4
-
9
-
-
0346094400
-
Identification of novel adrenomedullin in mammals: A potent cardiovascular and renal regulator
-
Takei, Y., Inoue, K., Ogoshi, M., Kawahara, T., Bannai, H., and Miyano, S. (2004) Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator. FEBS Lett. 556, 53-58
-
(2004)
FEBS Lett.
, vol.556
, pp. 53-58
-
-
Takei, Y.1
Inoue, K.2
Ogoshi, M.3
Kawahara, T.4
Bannai, H.5
Miyano, S.6
-
10
-
-
79951513390
-
Calcitonin gene-related peptide (CGRP) and its role in hypertension
-
Smillie, S. J., and Brain, S. D. (2011) Calcitonin gene-related peptide (CGRP) and its role in hypertension. Neuropeptides 45, 93-104
-
(2011)
Neuropeptides
, vol.45
, pp. 93-104
-
-
Smillie, S.J.1
Brain, S.D.2
-
11
-
-
77958454620
-
The first clinical pilot study of intravenous adrenomedullin administration in patients with acute myocardial infarction
-
Kataoka, Y., Miyazaki, S., Yasuda, S., Nagaya, N., Noguchi, T., Yamada, N., (2010) The first clinical pilot study of intravenous adrenomedullin administration in patients with acute myocardial infarction. J. Cardiovasc. Pharmacol. 56, 413-419
-
(2010)
J. Cardiovasc. Pharmacol.
, vol.56
, pp. 413-419
-
-
Kataoka, Y.1
Miyazaki, S.2
Yasuda, S.3
Nagaya, N.4
Noguchi, T.5
Yamada, N.6
-
12
-
-
0036266044
-
International union of pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors
-
Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., and Foord, S. M. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 54, 233-246
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 233-246
-
-
Poyner, D.R.1
Sexton, P.M.2
Marshall, I.3
Smith, D.M.4
Quirion, R.5
Born, W.6
Muff, R.7
Fischer, J.A.8
Foord, S.M.9
-
13
-
-
0032574982
-
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
-
McLatchie, L.M., Fraser, N. J., Main, M. J., Wise, A., Brown, J., Thompson, N., Solari, R., Lee, M. G., and Foord, S. M. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393, 333-339
-
(1998)
Nature
, vol.393
, pp. 333-339
-
-
McLatchie, L.M.1
Fraser, N.J.2
Main, M.J.3
Wise, A.4
Brown, J.5
Thompson, N.6
Solari, R.7
Lee, M.G.8
Foord, S.M.9
-
14
-
-
12244290339
-
Desensitisation of adrenomedullin and CGRP receptors
-
Hay, D. L., Poyner, D. R., and Smith, D. M. (2003) Desensitisation of adrenomedullin and CGRP receptors. Regul. Pept. 112, 139-145
-
(2003)
Regul. Pept.
, vol.112
, pp. 139-145
-
-
Hay, D.L.1
Poyner, D.R.2
Smith, D.M.3
-
15
-
-
77956898559
-
Regulation of signal transduction by calcitonin gene-related peptide receptors
-
Walker, C. S., Conner, A. C., Poyner, D. R., and Hay, D. L. (2010) Regulation of signal transduction by calcitonin gene-related peptide receptors. Trends Pharmacol. Sci. 31, 476-483
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 476-483
-
-
Walker, C.S.1
Conner, A.C.2
Poyner, D.R.3
Hay, D.L.4
-
16
-
-
84882662263
-
Comparing the molecular pharmacology of CGRP and adrenomedullin
-
Woolley, M. J., and Conner, A. C. (2013) Comparing the molecular pharmacology of CGRP and adrenomedullin. Curr. Protein Pept. Sci. 14, 358-374
-
(2013)
Curr. Protein Pept. Sci.
, vol.14
, pp. 358-374
-
-
Woolley, M.J.1
Conner, A.C.2
-
17
-
-
0026658222
-
2+ current in rat nodose neurones via a pertussis toxin-sensitive pathway
-
2+ current in rat nodose neurones via a pertussis toxin-sensitive pathway. J. Physiol. 455, 367-381
-
(1992)
J. Physiol.
, vol.455
, pp. 367-381
-
-
Wiley, J.W.1
Gross, R.A.2
MacDonald, R.L.3
-
18
-
-
0033766333
-
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line
-
Disa, J., Parameswaran, N., Nambi, P., and Aiyar, N. (2000) Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line. Neuropeptides 34, 229-233
-
(2000)
Neuropeptides
, vol.34
, pp. 229-233
-
-
Disa, J.1
Parameswaran, N.2
Nambi, P.3
Aiyar, N.4
-
19
-
-
0025909681
-
Calcitonin-gene-related peptide activates the muscarinicgated K+ current in atrial cells
-
Kim D. (1991) Calcitonin-gene-related peptide activates the muscarinicgated K+ current in atrial cells. Pflugers Arch. 418, 338-345
-
(1991)
Pflugers Arch.
, vol.418
, pp. 338-345
-
-
Kim, D.1
-
20
-
-
0032421501
-
The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins
-
Main, M. J., Brown, J., Brown, S., Fraser, N. J., and Foord, S. M. (1998) The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins. FEBS Lett. 441, 6-10
-
(1998)
FEBS Lett.
, vol.441
, pp. 6-10
-
-
Main, M.J.1
Brown, J.2
Brown, S.3
Fraser, N.J.4
Foord, S.M.5
-
21
-
-
76349122649
-
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2
-
Kuwasako, K., Kitamura, K., Nagata, S., Hikosaka, T., and Kato, J. (2010) Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. Biochem. Biophys. Res. Commun. 392, 380-385
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.392
, pp. 380-385
-
-
Kuwasako, K.1
Kitamura, K.2
Nagata, S.3
Hikosaka, T.4
Kato, J.5
-
22
-
-
0036453997
-
Yeast assays for G-protein-coupled receptors
-
Dowell, S. J., and Brown, A. J. (2002) Yeast assays for G-protein-coupled receptors. Receptors Channels 8, 343-352
-
(2002)
Receptors Channels
, vol.8
, pp. 343-352
-
-
Dowell, S.J.1
Brown, A.J.2
-
23
-
-
20644449483
-
Functional analysis of heterologous GPCR signalling pathways in yeast
-
Ladds, G., Goddard, A., and Davey, J. (2005) Functional analysis of heterologous GPCR signalling pathways in yeast. Trends Biotechnol. 23, 367-373
-
(2005)
Trends Biotechnol.
, vol.23
, pp. 367-373
-
-
Ladds, G.1
Goddard, A.2
Davey, J.3
-
24
-
-
84904546714
-
Investigating gprotein signalling bias at the glucagon-like peptide-1 receptor in yeast
-
Weston, C., Poyner, D., Patel, V., Dowell, S., and Ladds, G. (2014) Investigating Gprotein signalling bias at the glucagon-like peptide-1 receptor in yeast. Br. J. Pharmacol. 171, 3651-3665
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 3651-3665
-
-
Weston, C.1
Poyner, D.2
Patel, V.3
Dowell, S.4
Ladds, G.5
-
25
-
-
84942860294
-
Modulation of glucagon receptor pharmacology by RAMP2
-
Weston, C., Lu, J., Li, N., Barkan, K., Richards, G. O., Roberts, D. J., Skerry, T. M., Poyner, D., Pardamwar, M., Reynolds, C. A., Dowell, S. J., Willars, G. B., and Ladds, G. (2015) Modulation of glucagon receptor pharmacology by RAMP2. J. Biol. Chem. 290, 23009-23022
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 23009-23022
-
-
Weston, C.1
Lu, J.2
Li, N.3
Barkan, K.4
Richards, G.O.5
Roberts, D.J.6
Skerry, T.M.7
Poyner, D.8
Pardamwar, M.9
Reynolds, C.A.10
Dowell, S.J.11
Willars, G.B.12
Ladds, G.13
-
26
-
-
0036510377
-
Functional expression of heteromeric calcitonin gene-related peptide and adrenomedullin receptors in yeast
-
Miret, J. J., Rakhilina, L., Silverman, L., and Oehlen, B. (2002) Functional expression of heteromeric calcitonin gene-related peptide and adrenomedullin receptors in yeast. J. Biol. Chem. 277, 6881-6887
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6881-6887
-
-
Miret, J.J.1
Rakhilina, L.2
Silverman, L.3
Oehlen, B.4
-
27
-
-
84971290136
-
Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties
-
Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M., Pardamwar, M., McElhinney, J. M., Lathbridge, A., Constantine, A., Harris, P. W., Yuen, T. Y., Brimble, M. A., Barwell, J., Poyner, D. R., Woolley, M. J., et al. (2016) Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. J. Biol. Chem. 291, 11657-11675
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 11657-11675
-
-
Watkins, H.A.1
Chakravarthy, M.2
Abhayawardana, R.S.3
Gingell, J.J.4
Garelja, M.5
Pardamwar, M.6
McElhinney, J.M.7
Lathbridge, A.8
Constantine, A.9
Harris, P.W.10
Yuen, T.Y.11
Brimble, M.A.12
Barwell, J.13
Poyner, D.R.14
Woolley, M.J.15
-
28
-
-
84975229526
-
The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism
-
Wootten, D., Reynolds, C. A., Smith, K. J., Mobarec, J. C., Koole, C., Savage, E. E., Pabreja, K., Simms, J., Sridhar, R., Furness, S. G., Liu, M., Thompson, P. E., Miller, L. J., Christopoulos, A., and Sexton, P. M. (2016) The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell 165, 1632-1643
-
(2016)
Cell
, vol.165
, pp. 1632-1643
-
-
Wootten, D.1
Reynolds, C.A.2
Smith, K.J.3
Mobarec, J.C.4
Koole, C.5
Savage, E.E.6
Pabreja, K.7
Simms, J.8
Sridhar, R.9
Furness, S.G.10
Liu, M.11
Thompson, P.E.12
Miller, L.J.13
Christopoulos, A.14
Sexton, P.M.15
-
29
-
-
84962267960
-
A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: Lessons from class B crystal structures
-
Wootten, D., Reynolds, C. A., Koole, C., Smith, K. J., Mobarec, J. C., Simms, J., Quon, T., Coudrat, T., Furness, S. G., Miller, L. J., Christopoulos, A., and Sexton, P. M. (2016) A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures. Mol. Pharmacol. 89, 335-347
-
(2016)
Mol. Pharmacol.
, vol.89
, pp. 335-347
-
-
Wootten, D.1
Reynolds, C.A.2
Koole, C.3
Smith, K.J.4
Mobarec, J.C.5
Simms, J.6
Quon, T.7
Coudrat, T.8
Furness, S.G.9
Miller, L.J.10
Christopoulos, A.11
Sexton, P.M.12
-
30
-
-
84975078280
-
Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R)
-
Yang, D., de Graaf, C., Yang, L., Song, G., Dai, A., Cai, X., Feng, Y., Reedtz-Runge, S., Hanson, M. A., Yang, H., Jiang, H., Stevens, R. C., and Wang, M. W. (2016) Structural determinants of binding the seven-transmembrane domain of the glucagon-like peptide-1 receptor (GLP-1R). J. Biol. Chem. 291, 12991-13004
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 12991-13004
-
-
Yang, D.1
De Graaf, C.2
Yang, L.3
Song, G.4
Dai, A.5
Cai, X.6
Feng, Y.7
Reedtz-Runge, S.8
Hanson, M.A.9
Yang, H.10
Jiang, H.11
Stevens, R.C.12
Wang, M.W.13
-
31
-
-
84938517765
-
Conformational states of the full-length glucagon receptor
-
Yang, L., Yang, D., de Graaf, C., Moeller, A., West, G. M., Dharmarajan, V., Wang, C., Siu, F. Y., Song, G., Reedtz-Runge, S., Pascal, B. D., Wu, B., Potter, C. S., Zhou, H., Griffin, P. R., et al. (2015) Conformational states of the full-length glucagon receptor. Nat. Commun. 6, 7859
-
(2015)
Nat. Commun.
, vol.6
, pp. 7859
-
-
Yang, L.1
Yang, D.2
De Graaf, C.3
Moeller, A.4
West, G.M.5
Dharmarajan, V.6
Wang, C.7
Siu, F.Y.8
Song, G.9
Reedtz-Runge, S.10
Pascal, B.D.11
Wu, B.12
Potter, C.S.13
Zhou, H.14
Griffin, P.R.15
-
32
-
-
84923337570
-
Activation of corticotropin-releasing factor 1 receptor: Insights from molecular dynamics simulations
-
Singh, R., Ahalawat, N., and Murarka, R. K. (2015) Activation of corticotropin-releasing factor 1 receptor: insights from molecular dynamics simulations. J. Phys. Chem. B 119, 2806-2817
-
(2015)
J. Phys. Chem. B
, vol.119
, pp. 2806-2817
-
-
Singh, R.1
Ahalawat, N.2
Murarka, R.K.3
-
33
-
-
84973579909
-
Activation and conformational dynamics of a class B G-protein-coupled glucagon receptor
-
Li, Y., Sun, J., Li, D., and Lin, J. (2016) Activation and conformational dynamics of a class B G-protein-coupled glucagon receptor. Phys. Chem. Chem. Phys. 18, 12642-12650
-
(2016)
Phys. Chem. Chem. Phys.
, vol.18
, pp. 12642-12650
-
-
Li, Y.1
Sun, J.2
Li, D.3
Lin, J.4
-
34
-
-
0021058380
-
Operational models of pharmacological agonism
-
Black, J. W., and Leff, P. (1983) Operational models of pharmacological agonism. Proc. R. Soc. Lond. B Biol. Sci. 220, 141-162
-
(1983)
Proc. R. Soc. Lond. B Biol. Sci.
, vol.220
, pp. 141-162
-
-
Black, J.W.1
Leff, P.2
-
35
-
-
84907364884
-
Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations
-
Lin, Y. C., Boone, M., Meuris, L., Lemmens, I., Van Roy, N., Soete, A., Reumers, J., Moisse, M., Plaisance, S., Drmanac, R., Chen, J., Speleman, F., Lambrechts, D., Van de Peer, Y., Tavernier, J., and Callewaert, N. (2014) Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations. Nat. Commun. 5, 4767
-
(2014)
Nat. Commun.
, vol.5
, pp. 4767
-
-
Lin, Y.C.1
Boone, M.2
Meuris, L.3
Lemmens, I.4
Van Roy, N.5
Soete, A.6
Reumers, J.7
Moisse, M.8
Plaisance, S.9
Drmanac, R.10
Chen, J.11
Speleman, F.12
Lambrechts, D.13
Van De-Peer, Y.14
Tavernier, J.15
Callewaert, N.16
-
36
-
-
0021830055
-
Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells
-
Stillman, B. W., and Gluzman, Y. (1985) Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol. Cell. Biol. 5, 2051-2060
-
(1985)
Mol. Cell. Biol.
, vol.5
, pp. 2051-2060
-
-
Stillman, B.W.1
Gluzman, Y.2
-
37
-
-
84872946955
-
Receptor activity modifying proteins (RAMPs) interact with the VPAC 2 receptor and CRF1 receptors and modulate their function
-
Wootten, D., Lindmark, H., Kadmiel, M., Willcockson, H., Caron, K. M., Barwell, J., Drmota, T., and Poyner, D. R. (2013) Receptor activity modifying proteins (RAMPs) interact with the VPAC 2 receptor and CRF1 receptors and modulate their function. Br. J. Pharmacol. 168, 822-834
-
(2013)
Br. J. Pharmacol.
, vol.168
, pp. 822-834
-
-
Wootten, D.1
Lindmark, H.2
Kadmiel, M.3
Willcockson, H.4
Caron, K.M.5
Barwell, J.6
Drmota, T.7
Poyner, D.R.8
-
38
-
-
84872381155
-
Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47) hCT((a)) function
-
Qi, T., Dong, M., Watkins, H. A., Wootten, D., Miller, L. J., and Hay, D. L. (2013) Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47) hCT((a)) function. Br. J. Pharmacol. 168, 644-657
-
(2013)
Br. J. Pharmacol.
, vol.168
, pp. 644-657
-
-
Qi, T.1
Dong, M.2
Watkins, H.A.3
Wootten, D.4
Miller, L.J.5
Hay, D.L.6
-
39
-
-
85009877618
-
Receptor activity-modifying proteins: Multifunctional G protein-coupled receptor accessory proteins
-
Hay, D. L., Walker, C. S., Gingell, J. J., Ladds, G., Reynolds, C. A., and Poyner, D. R. (2016) Receptor activity-modifying proteins: multifunctional G protein-coupled receptor accessory proteins. Biochem. Soc. Trans. 44, 568-573
-
(2016)
Biochem. Soc. Trans.
, vol.44
, pp. 568-573
-
-
Hay, D.L.1
Walker, C.S.2
Gingell, J.J.3
Ladds, G.4
Reynolds, C.A.5
Poyner, D.R.6
-
40
-
-
78650926798
-
Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
-
Atwood, B. K., Lopez, J., Wager-Miller, J., Mackie, K., and Straiker, A. (2011) Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. BMC Genomics 12, 14
-
(2011)
BMC Genomics
, vol.12
, pp. 14
-
-
Atwood, B.K.1
Lopez, J.2
Wager-Miller, J.3
Mackie, K.4
Straiker, A.5
-
41
-
-
59149084759
-
Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes
-
Figueroa, K. W., Griffin, M. T., and Ehlert, F. J. (2009) Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes. J. Pharmacol. Exp. Ther. 328, 331-342
-
(2009)
J. Pharmacol. Exp. Ther.
, vol.328
, pp. 331-342
-
-
Figueroa, K.W.1
Griffin, M.T.2
Ehlert, F.J.3
-
42
-
-
9144273884
-
q/11-selective inhibitor
-
q/11-selective inhibitor. J. Biol. Chem. 279, 47438-47445
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47438-47445
-
-
Takasaki, J.1
Saito, T.2
Taniguchi, M.3
Kawasaki, T.4
Moritani, Y.5
Hayashi, K.6
Kobori, M.7
-
43
-
-
41149100649
-
Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines
-
Wunder, F., Rebmann, A., Geerts, A., and Kalthof, B. (2008) Pharmacological and kinetic characterization of adrenomedullin 1 and calcitonin gene-related peptide 1 receptor reporter cell lines. Mol. Pharmacol. 73, 1235-1243
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 1235-1243
-
-
Wunder, F.1
Rebmann, A.2
Geerts, A.3
Kalthof, B.4
-
44
-
-
84892378394
-
Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: Implications for adrenomedullin and calcitonin gene-related peptide pharmacology
-
Watkins, H. A., Walker, C. S., Ly, K. N., Bailey, R. J., Barwell, J., Poyner, D. R., and Hay, D. L. (2014) Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology. Br. J. Pharmacol. 171, 772-788
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 772-788
-
-
Watkins, H.A.1
Walker, C.S.2
Ly, K.N.3
Bailey, R.J.4
Barwell, J.5
Poyner, D.R.6
Hay, D.L.7
-
46
-
-
0033039911
-
Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product
-
Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M., and Sexton, P. M. (1999) Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol. Pharmacol. 56, 235-242
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 235-242
-
-
Christopoulos, G.1
Perry, K.J.2
Morfis, M.3
Tilakaratne, N.4
Gao, Y.5
Fraser, N.J.6
Main, M.J.7
Foord, S.M.8
Sexton, P.M.9
-
47
-
-
0028922340
-
2+ mobilization, in bovine aortic endothelial cells
-
2+ mobilization, in bovine aortic endothelial cells. J. Biol. Chem. 270, 4412-4417
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 4412-4417
-
-
Shimekake, Y.1
Nagata, K.2
Ohta, S.3
Kambayashi, Y.4
Teraoka, H.5
Kitamura, K.6
Eto, T.7
Kangawa, K.8
Matsuo, H.9
-
48
-
-
84948432286
-
Calcitonin gene-related peptide mediates an inflammatory response in schwann cells via cAMP-dependent ERK signaling cascade
-
Permpoonputtana, K., Porter, J. E., Govitrapong, P. (2016) Calcitonin gene-related peptide mediates an inflammatory response in Schwann cells via cAMP-dependent ERK signaling cascade. Life Sci. 144, 19-25
-
(2016)
Life Sci.
, vol.144
, pp. 19-25
-
-
Permpoonputtana, K.1
Porter, J.E.2
Govitrapong, P.3
-
49
-
-
71549119499
-
Molecular basis of association of receptor activity-modifying protein 3 with the family B G-protein-coupled secretin receptor
-
Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M., and Miller, L. J. (2009) Molecular basis of association of receptor activity-modifying protein 3 with the family B G-protein-coupled secretin receptor. Biochemistry 48, 11773-11785
-
(2009)
Biochemistry
, vol.48
, pp. 11773-11785
-
-
Harikumar, K.G.1
Simms, J.2
Christopoulos, G.3
Sexton, P.M.4
Miller, L.J.5
-
50
-
-
80051658642
-
s protein complex
-
s protein complex. Nature 477, 549-555
-
(2011)
Nature
, vol.477
, pp. 549-555
-
-
Rasmussen, S.G.1
DeVree, B.T.2
Zou, Y.3
Kruse, A.C.4
Chung, K.Y.5
Kobilka, T.S.6
Thian, F.S.7
Chae, P.S.8
Pardon, E.9
Calinski, D.10
Mathiesen, J.M.11
Shah, S.T.12
Lyons, J.A.13
Caffrey, M.14
Gellman, S.H.15
-
51
-
-
0037241864
-
Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins
-
Ladds, G., Davis, K., Hillhouse, E. W., and Davey, J. (2003) Modified yeast cells to investigate the coupling of G protein-coupled receptors to specific G proteins. Mol. Microbiol. 47, 781-792
-
(2003)
Mol. Microbiol.
, vol.47
, pp. 781-792
-
-
Ladds, G.1
Davis, K.2
Hillhouse, E.W.3
Davey, J.4
-
52
-
-
0038363378
-
The orphan gprotein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
-
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., Pike, N. B., Strum, J. C., Steplewski, K. M., Murdock, P. R., Holder, J. C., et al. (2003) The orphan Gprotein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 278, 11312-11319
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11312-11319
-
-
Brown, A.J.1
Goldsworthy, S.M.2
Barnes, A.A.3
Eilert, M.M.4
Tcheang, L.5
Daniels, D.6
Muir, A.I.7
Wigglesworth, M.J.8
Kinghorn, I.9
Fraser, N.J.10
Pike, N.B.11
Strum, J.C.12
Steplewski, K.M.13
Murdock, P.R.14
Holder, J.C.15
-
53
-
-
34347270219
-
Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method
-
Gietz, R. D., and Schiestl, R. H. (2007) Quick and easy yeast transformation using the LiAc/SS carrier DNA/PEG method. Nat. Protoc. 2, 35-37
-
(2007)
Nat. Protoc.
, vol.2
, pp. 35-37
-
-
Gietz, R.D.1
Schiestl, R.H.2
-
54
-
-
77952581108
-
A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor
-
Gingell, J. J., Qi, T., Bailey, R. J., and Hay, D. L. (2010) A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor. Peptides 31, 1400-1404
-
(2010)
Peptides
, vol.31
, pp. 1400-1404
-
-
Gingell, J.J.1
Qi, T.2
Bailey, R.J.3
Hay, D.L.4
-
55
-
-
65049090687
-
Regulators of G protein signalling proteins in the human myometrium
-
Ladds, G., Zervou, S., Vatish, M., Thornton, S., and Davey, J. (2009) Regulators of G protein signalling proteins in the human myometrium. Eur. J. Pharmacol. 610, 23-28
-
(2009)
Eur. J. Pharmacol.
, vol.610
, pp. 23-28
-
-
Ladds, G.1
Zervou, S.2
Vatish, M.3
Thornton, S.4
Davey, J.5
-
56
-
-
75549089019
-
Primer bank: A resource of human and mouse PCR primer pairs for gene expression detection and quantification
-
Spandidos, A., Wang, X., Wang, H., and Seed, B. (2010) Primer Bank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res. 38, D729-D799
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. D729-D799
-
-
Spandidos, A.1
Wang, X.2
Wang, H.3
Seed, B.4
-
57
-
-
85023202760
-
Comparative protein structure modeling using MODELLER
-
Webb, B., and Sali, A. (2016) Comparative protein structure modeling using MODELLER. Curr. Protoc. Bioinformatics 54, 5.6.1-5.6.37
-
(2016)
Curr. Protoc. Bioinformatics
, vol.54
, pp. 1-37
-
-
Webb, B.1
Sali, A.2
-
58
-
-
84881193006
-
Structure of the human glucagon class B G-protein-coupled receptor
-
Siu, F. Y., He, M., de Graaf, C., Han, G. W., Yang, D., Zhang, Z., Zhou, C., Xu, Q., Wacker, D., Joseph, J. S., Liu, W., Lau, J., Cherezov, V., Katritch, V., Wang, M. W., and Stevens, R. C. (2013) Structure of the human glucagon class B G-protein-coupled receptor. Nature 499, 444-449
-
(2013)
Nature
, vol.499
, pp. 444-449
-
-
Siu, F.Y.1
He, M.2
De Graaf, C.3
Han, G.W.4
Yang, D.5
Zhang, Z.6
Zhou, C.7
Xu, Q.8
Wacker, D.9
Joseph, J.S.10
Liu, W.11
Lau, J.12
Cherezov, V.13
Katritch, V.14
Wang, M.W.15
Stevens, R.C.16
-
59
-
-
84881173408
-
Structure of class B GPCR corticotropin-releasing factor receptor 1
-
Hollenstein, K., Kean, J., Bortolato, A., Cheng, R. K., Doré, A. S., Jazayeri, A., Cooke, R. M., Weir, M., and Marshall, F. H. (2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499, 438-443
-
(2013)
Nature
, vol.499
, pp. 438-443
-
-
Hollenstein, K.1
Kean, J.2
Bortolato, A.3
Cheng, R.K.4
Doré, A.S.5
Jazayeri, A.6
Cooke, R.M.7
Weir, M.8
Marshall, F.H.9
-
60
-
-
84937629357
-
Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor
-
Booe, J. M., Walker, C. S., Barwell, J., Kuteyi, G., Simms, J., Jamaluddin, M. A., Warner, M. L., Bill, R. M., Harris, P. W., Brimble, M. A., Poyner, D. R., Hay, D. L., and Pioszak, A. A. (2015) Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Mol. Cell 58, 1040-1052
-
(2015)
Mol. Cell
, vol.58
, pp. 1040-1052
-
-
Booe, J.M.1
Walker, C.S.2
Barwell, J.3
Kuteyi, G.4
Simms, J.5
Jamaluddin, M.A.6
Warner, M.L.7
Bill, R.M.8
Harris, P.W.9
Brimble, M.A.10
Poyner, D.R.11
Hay, D.L.12
Pioszak, A.A.13
-
61
-
-
84865994337
-
Molecular basis for negative regulation of the glucagon receptor
-
Koth, C. M., Murray, J. M., Mukund, S., Madjidi, A., Minn, A., Clarke, H. J., Wong, T., Chiang, V., Luis, E., Estevez, A., Rondon, J., Zhang, Y., Hötzel, I., and Allan, B. B. (2012) Molecular basis for negative regulation of the glucagon receptor. Proc. Natl. Acad. Sci. U S A. 109, 14393-14398
-
(2012)
Proc. Natl. Acad. Sci. U S A.
, vol.109
, pp. 14393-14398
-
-
Koth, C.M.1
Murray, J.M.2
Mukund, S.3
Madjidi, A.4
Minn, A.5
Clarke, H.J.6
Wong, T.7
Chiang, V.8
Luis, E.9
Estevez, A.10
Rondon, J.11
Zhang, Y.12
Hötzel, I.13
Allan, B.B.14
-
62
-
-
84929346697
-
Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists
-
Hoang, H. N., Song, K., Hill, T. A., Derksen, D. R., Edmonds, D. J., Kok, W. M., Limberakis, C., Liras, S., Loria, P. M., Mascitti, V., Mathiowetz, A. M., Mitchell, J. M., Piotrowski, D. W., Price, D. A., Stanton, R. V., et al. (2015) Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. J. Med. Chem. 58, 4080-4085
-
(2015)
J. Med. Chem.
, vol.58
, pp. 4080-4085
-
-
Hoang, H.N.1
Song, K.2
Hill, T.A.3
Derksen, D.R.4
Edmonds, D.J.5
Kok, W.M.6
Limberakis, C.7
Liras, S.8
Loria, P.M.9
Mascitti, V.10
Mathiowetz, A.M.11
Mitchell, J.M.12
Piotrowski, D.W.13
Price, D.A.14
Stanton, R.V.15
-
63
-
-
80055027760
-
Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules
-
Pérez-Castells, J., Martín-Santamaría, S., Nieto, L., Ramos, A., Martínez, A., Pascual-Teresa, Bd., and Jiménez-Barbero, J. (2012) Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules. Biopolymers 97, 45-53
-
(2012)
Biopolymers
, vol.97
, pp. 45-53
-
-
Pérez-Castells, J.1
Martín-Santamaría, S.2
Nieto, L.3
Ramos, A.4
Martínez, A.5
Pascual-Teresa, B.6
Jiménez-Barbero, J.7
-
64
-
-
47149096704
-
CHARMM-GUI: A web-based graphical user interface for CHARMM
-
Jo, S., Kim, T., Iyer, V. G., and Im, W. (2008) CHARMM-GUI: a Web-based graphical user interface for CHARMM. J. Comput. Chem. 29, 1859-1865
-
(2008)
J. Comput. Chem.
, vol.29
, pp. 1859-1865
-
-
Jo, S.1
Kim, T.2
Iyer, V.G.3
Im, W.4
-
65
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., and Klein, M. L. (1983) Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 79, 926-935
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Impey, R.W.4
Klein, M.L.5
-
66
-
-
3242886771
-
PDB2PQR: An automated pipeline for the setup of poisson-boltzmann electrostatics calculations
-
Dolinsky, T. J., Nielsen, J. E., McCammon, J. A., and Baker, N. A. (2004) PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res. 32, W665-W667
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. W665-W667
-
-
Dolinsky, T.J.1
Nielsen, J.E.2
McCammon, J.A.3
Baker, N.A.4
-
67
-
-
33748518255
-
Comparison of multiple amber force fields and development of improved protein backbone parameters
-
Hornak, V., Abel, R., Okur, A., Strockbine, B., Roitberg, A., and Simmerling, C. (2006) Comparison of multiple Amber force fields and development of improved protein backbone parameters. Proteins 65, 712-725
-
(2006)
Proteins
, vol.65
, pp. 712-725
-
-
Hornak, V.1
Abel, R.2
Okur, A.3
Strockbine, B.4
Roitberg, A.5
Simmerling, C.6
-
68
-
-
84991748654
-
Amber lipid force field: Lipid14 and beyond
-
San Francisco, August 10-14, 2016, 163-COMP, American Chemical Society, Washington, DC
-
Walker, R. C., Dickson, C. J., Madej, B. D., Skjevik, A. A., Betz, R. M., Teigen, K., and Gould, I. R. (2014) Amber lipid force field: Lipid14 and beyond, in Abstracts of the 248th National Meeting of the American Chemical Society, San Francisco, August 10-14, 2016, 163-COMP, American Chemical Society, Washington, DC
-
(2014)
Abstracts of the 248th National Meeting of the American Chemical Society
-
-
Walker, R.C.1
Dickson, C.J.2
Madej, B.D.3
Skjevik, A.A.4
Betz, R.M.5
Teigen, K.6
Gould, I.R.7
-
69
-
-
84894191473
-
Lipid14: The amber lipid force field
-
Dickson, C. J., Madej, B. D., Skjevik, A. A., Betz, R. M., Teigen, K., Gould, I. R., and Walker, R. C. (2014) Lipid14: the Amber lipid force field. J. Chem. Theory Comput. 10, 865-879
-
(2014)
J. Chem. Theory Comput.
, vol.10
, pp. 865-879
-
-
Dickson, C.J.1
Madej, B.D.2
Skjevik, A.A.3
Betz, R.M.4
Teigen, K.5
Gould, I.R.6
Walker, R.C.7
-
70
-
-
84980364284
-
-
University of California, San Francisco
-
Case, D. A., Betz, R. M., Botello-Smith, W., Cerutti, D. S., Cheatham, T. E., III, et al. (2016) AMBER 2016, University of California, San Francisco
-
(2016)
AMBER 2016
-
-
Case, D.A.1
Betz, R.M.2
Botello-Smith, W.3
Cerutti, D.S.4
Cheatham, T.E.5
-
71
-
-
67650099787
-
ACEMD: Accelerating biomolecular dynamics in the microsecond time scale
-
Harvey, M. J., Giupponi, G., and Fabritiis, G. D. (2009) ACEMD: accelerating biomolecular dynamics in the microsecond time scale. J. Chem. Theory Comput. 5, 1632-1639
-
(2009)
J. Chem. Theory Comput.
, vol.5
, pp. 1632-1639
-
-
Harvey, M.J.1
Giupponi, G.2
Fabritiis, G.D.3
-
72
-
-
0034650702
-
Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α-subunit chimeras
-
Brown, A. J., Dyos, S. L., Whiteway, M. S., White, J. H., Watson, M. A., Marzioch, M., Clare, J. J., Cousens, D. J., Paddon, C., Plumpton, C., Romanos, M. A., and Dowell, S. J. (2000) Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α-subunit chimeras. Yeast 16, 11-22
-
(2000)
Yeast
, vol.16
, pp. 11-22
-
-
Brown, A.J.1
Dyos, S.L.2
Whiteway, M.S.3
White, J.H.4
Watson, M.A.5
Marzioch, M.6
Clare, J.J.7
Cousens, D.J.8
Paddon, C.9
Plumpton, C.10
Romanos, M.A.11
Dowell, S.J.12
|