Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists

Journal of Medicinal Chemistry

Volumn 58, Issue 9, 2015, Pages 4080-4085

  Hoang, Huy N ^a   Song, Kun ^b   Hill, Timothy A ^a   Derksen, David R ^b   Edmonds, David J ^b   Kok, W Mei ^a   Limberakis, Chris ^b   Liras, Spiros ^b   Loria, Paula M ^b   Mascitti, Vincent ^b   Mathiowetz, Alan M ^b   Mitchell, Justin M ^a   Piotrowski, David W ^b   Price, David A ^b   Stanton, Robert V ^b   Suen, Jacky Y ^a   Withka, Jane M ^b   Griffith, David A ^b   Fairlie, David P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; PEPTIDE; CYCLOPEPTIDE; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR;

AGONIST POTENCY; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CIRCULAR DICHROISM; CYCLIZATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; HYDROPHOBICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; AGONISTS; ANIMAL; BIOSYNTHESIS; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; RADIOASSAY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CIRCULAR DICHROISM; CRICETULUS; CYCLIC AMP; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84929346697     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00166     Document Type: Article

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