Structure of micelle-bound adrenomedullin: A first step toward the analysis of its interactions with receptors and small molecules

Biopolymers

Volumn 97, Issue 1, 2012, Pages 45-53

  Pérez Castells, Javier ^a   Martín Santamaría, Sonsoles ^a   Nieto, Lidia ^b   Ramos, Ana ^a   Martínez, Alfredo ^c   Pascual Teresa, Beatriz De ^a   Jiménez Barbero, Jesús ^b  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c CENTER FOR BIOMEDICAL RESEARCH OF LA RIOJA CIBIR   (Spain)

Author keywords

adrenomedullin; membrane like environment; NMR; structure

Indexed keywords

ADRENOMEDULLIN; ANGIOGENESIS; ANTI-MICROBIAL ACTIVITY; BINDING PROTEINS; CHEMICAL SHIFT PERTURBATIONS; EXPERIMENTAL CONDITIONS; HELICAL STRUCTURES; MEMBRANE-LIKE ENVIRONMENT; PATHOPHYSIOLOGY; REGULATORY PEPTIDE; SMALL MOLECULES; THERAPEUTIC POTENTIALS; THREE-DIMENSIONAL STRUCTURE; TOTAL LENGTH;

CELL DEATH; ISOMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PERTURBATION TECHNIQUES; PHYSIOLOGY; SPECTROSCOPIC ANALYSIS;

MOLECULES;

ADRENOMEDULLIN; ADRENOMEDULLIN RECEPTOR;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CIRCULAR DICHROISM; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PROTEIN PROTEIN INTERACTION;

ADRENOMEDULLIN; CARRIER PROTEINS; CIRCULAR DICHROISM; HUMANS; LABORATORY CHEMICALS; MICELLES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ADRENOMEDULLIN; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80055027760     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21700     Document Type: Article

References (49)

1. Lopez, J.,;, Martinez, A., Int Rev Cytol 2002, 221, 1-92.
2. Martinez, A.,;, Oh, H. R.,;, Unsworth, E. J.,;, Bregonzio, C.,;, Saavedra, J. M.,;, Stetler-Stevenson, W. G.,;, Cuttitta, F., Biochem J 2004, 383, 413-418.
3. McLatchie, L. M.,;, Fraser, N. J.,;, Main, M. J.,;, Wise, A.,;, Brown, J.,;, Thompson, N.,;, Solari, R.,;, Lee, M. G.,;, Foord, S. M., Nature 1998, 393, 333-339.
4. Elsasser, T. H.,;, Kahl, S.,;, Martinez, A.,;, Montuenga, L. M.,;, Pio, R.,;, Cuttitta, F., Endocrinology 1999, 140, 4908-4911.
5. Pio, R.,;, Martinez, A.,;, Unsworth, E. J.,;, Kowalak, J. A.,;, Bengoechea, J. A.,;, Zipfel, P. F.,;, Elsasser, T. H.,;, Cuttitta, F., J Biol Chem 2001, 276, 12292-12300.
6. Zudaire, E.,;, Martinez, A.,;, Cuttitta, F., Regul Pept 2003, 112, 175-183.
7. Zudaire, E.,;, Cuttitta, F.,;, Martinez, A., Regul Pept 2003, 112, 121-130.
8. Lainchbury, J. G.,;, Cooper, G. J.,;, Coy, D. H.,;, Jiang, N. Y.,;, Lewis, L. K.,;, Yandle, T. G.,;, Richards, A. M.,;, Nicholls, M. G., Clin Sci (London) 1997, 92, 467-472.
9. Shimosawa, T.,;, Fujita, T., Drug News Perspect 2005, 18, 185-189.
10. Nishikimi, T., Curr Med Chem 2007, 14, 1689-1699.
11. Ishimitsu, T.,;, Ono, H.,;, Minami, J.,;, Matsuoka, H., Pharmacol Ther 2006, 111, 909-927.
12. Miyamoto, N.,;, Tanaka, R.,;, Shimosawa, T.,;, Yatomi, Y.,;, Fujita, T.,;, Hattori, N.,;, Urabe, T., J Cereb Blood Flow Metab 2009, 29, 1769-1779.
13. Garcia, M. A.,;, Martin-Santamaria, S.,;, de Pascual-Teresa, B.,;, Ramos, A.,;, Julian, M.,;, Martinez, A., Expert Opin Ther Targets 2006, 10, 303-317.
14. Martinez, A.,;, Weaver, C.,;, Lopez, J.,;, Bhathena, S. J.,;, Elsasser, T. H.,;, Miller, M. J.,;, Moody, T. W.,;, Unsworth, E. J.,;, Cuttitta, F., Endocrinology 1996, 137, 2626-2632.
15. Ishikawa, T.,;, Chen, J.,;, Wang, J.,;, Okada, F.,;, Sugiyama, T.,;, Kobayashi, T.,;, Shindo, M.,;, Higashino, F.,;, Katoh, H.,;, Asaka, M.,;, Kondo, T.,;, Hosokawa, M.,;, Kobayashi, M., Oncogene 2003, 22, 1238-1242.
16. Martinez, A.,;, Julian, M.,;, Bregonzio, C.,;, Notari, L.,;, Moody, T. W.,;, Cuttitta, F., Endocrinology 2004, 145, 3858-3865.
17. Garcia, M. A.,;, Martin-Santamaria, S.,;, Cacho, M.,;, de la Llave, F. M.,;, Julian, M.,;, Martinez, A.,;, de Pascual-Teresa, B.,;, Ramos, A., J Med Chem 2005, 48, 4068-4075.
18. Roldós, V.,;, Martín-Santamaría, S.,;, Julián, M.,;, Martínez, A.,;, Choulier, L.,;, Altschuh, D.,;, de Pascual-Teresa, B.,;, Ramos, A., Chem Med Chem 2008, 3, 1345-1355.
19. Lucyk, S.,;, Taha, H.,;, Yamamoto, H.,;, Miskolzie, M.,;, Kotovych, G., Biopolymers 2006, 81, 295-308.
20. Breeze, A. L.,;, Harvey, T. S.,;, Bazzo, R.,;, Campbell, I. D., Biochemistry 1991, 30, 575-582.
21. Cort, J. R.,;, Liu, Z.,;, Lee, G. M.,;, Huggins, K. N.,;, Janes, S.,;, Prickett, K.,;, Andersen, N. H., Protein Eng Des Sel 2009, 22, 497-513.
22. Motta, A.,;, Temussi, P. A.,;, Wunsch, E.,;, Bovermann, G., Biochemistry 1991, 30, 2364-2371.
23. Robinson, S. D.,;, Aitken, J. F.,;, Bailey, R. J.,;, Poyner, D. R.,;, Hay, D. L., J Pharmacol Exp Ther 2009, 331, 513-521.
24. Meyer, B.,;, Peters, T., Angew Chem Int Ed Engl 2003, 42, 864-890.
25. Mayer, M.,;, Meyer, B., Angew Chem Int Ed Engl 1999, 38, 1784-1788.
26. Shuker, S. B.,;, Hajduk, P. J.,;, Meadows, R. P.,;, Fesik, S. W., Science 1996, 274, 1531-1534.
27. Dunker, A. K.,;, Uversky, V. N., Curr Opin Pharmacol 2010, 10, 782-788.
28. Ter, H. E.,;, Koth, C. M.,;, Abdul-Manan, N.,;, Swenson, L.,;, Coll, J. T.,;, Lippke, J. A.,;, Lepre, C. A.,;, Garcia-Guzman, M.,;, Moore, J. M., Structure 2010, 18, 1083-1093.
29. Allaker, R. P.,;, Zihni, C.,;, Kapas, S., FEMS Immunol Med Microbiol 1999, 23, 289-293.
30. Martinez, A.,;, Bengoechea, J. A.,;, Cuttitta, F., Endocrinology 2006, 147, 3457-3461.
31. Bulet, P.,;, Stocklin, R.,;, Menin, L., Immunol Rev 2004, 198, 169-184.
32. Parthier, C.,;, Reedtz-Runge, S.,;, Rudolph, R.,;, Stubbs, M.T., Trends Biochem Sci 2009, 34, 303-310.
33. Waddell, W. J., J Lab Clin Med 1956, 48, 311-314.
34. Chen, Y. H.,;, Yang, J. T., Biochem Biophys Res Commun 1971, 44, 1285-1291.
35. Piotto, M.,;, Saudek, V.,;, Sklenar, V., J Biomol NMR 1992, 2, 661-665.
36. Jeener, J.,;, Meier, B. H.,;, Bachmann, P.,;, Ernst, R. R., J Chem Phys 1979, 71, 4546-4553.
37. Griesinger, C.,;, Otting, G.,;, Wuthrich, K.,;, Ernst, R. R., J Am Chem Soc 1988, 110, 7870-7872.
38. Rucker, S. P.,;, Shaka, A., J Mol Phys 1989, 68, 509-517.
39. Bartels, C.,;, Xia, T. H.,;, Billeter, M.,;, Guntert, P.,;, Wuthrich, K., J Biomol NMR 1995, 6, 1-10.
40. Herrmann, T.,;, Guntert, P.,;, Wuthrich, K., J Mol Biol 2002, 319, 209-227.
41. Koradi, R.,;, Billeter, M.,;, Wuthrich, K., J Mol Graph 1996, 14, 51-55.
42. Laskowski, R. A.,;, Rullmann, J. A. C.,;, MacArthur, M. W.,;, Kaptein, R.,;, Thornton, J. M., J Biomol NMR 1996, 8, 477-486.
43. Frisch, M. J.,;, Trucks, G. W.,;, Schlegel, H. B.,;, Scuseria, G. E.,;, Robb, M. A.,;, Cheeseman, J. R.,;, Montgomery, J. J. A.,;, Vreven, T.,;, Kudin, K. N.,;, Burant, J. C.,;, Millam, J. M.,;, Iyengar, S. S.,;, Tomasi, J.,;, Barone, V.,;, Mennucci, B.,;, Cossi, M.,;, Scalmani, G.,;, Rega, N.,;, Petersson, G. A.,;, Nakatsuji, H.,;, Hada, M.,;, Ehara, M.,;, Toyota, K.,;, Fukuda, R.,;, Hasegawa, J.,;, Ishida, M.,;, Nakajima, T.,;, Honda, Y.,;, Kitao, O.,;, Nakai, H.,;, Klene, M.,;, Li, X.,;, Knox, J. E.,;, Hratchian, H. P.,;, Cross, J. B.,;, Bakken, V.,;, Adamo, C.,;, Jaramillo, J.,;, Gomperts, R.,;, Stratmann, R. E.,;, Yazyev, O.,;, Austin, A. J.,;, Cammi, R.,;, Pomelli, C.,;, Ochterski, J. W.,;, Ayala, P. Y.,;, Morokuma, K.,;, Voth, G. A.,;, Salvador, P.,;, Dannenberg, J. J.,;, Zakrzewski, V. G.,;, Dapprich, S.,;, Daniels, A. D.,;, Strain, M. C.,;, Farkas, O.,;, Malick, D. K.,;, Rabuck, A. D.,;, Raghavachari, K.,;, Foresman, J. B.,;, Ortiz, J. V.,;, Cui, Q.,;, Baboul, A. G.,;, Clifford, S.,;, Cioslowski, J.,;, Stefanov, B. B.,;, Liu, G.,;, Liashenko, A.,;, Piskorz, P.,;, Komaromi, I.,;, Martin, R. L.,;, Fox, D. J.,;, Keith, T.,;, Al-Laham, M. A.,;, Peng, C. Y.,;, Nanayakkara, A.,;, Challacombe, M.,;, Gill, P. M. W.,;, Johnson, B.,;, Chen, W.,;, Wong, M. W.,;, Gonzalez, C.,;, Pople, J. A.,: Wallingford CT, Gaussian 03, Gaussian, Inc., Wallingford CT,2004.
44. Bayly, C. I.,;, Cieplak, P.,;, Cornell, W.,;, Kollman, P. A., J Phys Chem 1993, 97, 10269-10280.
45. Case, D. A.,;, Darden, T. A.,;, Cheatham, T. E., III,;, Simmerling, C. L.,;, Wang, J.,;, Duke, R. E.,;, Luo, R. E.,;, Merz, K. M.,;, Wang, B.,;, Pearlman, D. A.,;, Crowley, M.,;, Brozell, S.,;, Tsui, V.,;, Gohlke, H.,;, Mongan, J.,;, Hornak, V.,;, Cui, G.,;, Beroza, P.,;, Schafmeister, C.,;, Caldwell, J. W.,;, Ross, W. S.,;, Kollman, P. A., AMBER 8, University of California, San Francisco 2004.
46. Miyamoto, S.,;, Kollman, P. A., J Comput Chem 1992, 13, 952-962.
47. Darden, T. A.,;, York, D.,;, Pedersen, L. G., J Chem Phys 1993, 98, 10089-10092.
48. Friesner, R. A.,;, Banks, J. L.,;, Murphy, R. B.,;, Halgren, T. A.,;, Klicic, J. J.,;, Mainz, D. T.,;, Repasky, M. P.,;, Knoll, E. H.,;, Shelley, M.,;, Perry, J. K.,;, Shaw, D. E.,;, Francis, P.,;, Shenkin, P. S., J Med Chem 2004, 47, 1739-1749.
49. Friesner, R. A.,;, Murphy, R. B.,;, Repasky, M. P.,;, Frye, L. L.,;, Greenwood, J. R.,;, Halgren, T. A.,;, Sanschagrin, P. C.,;, Mainz, D. T., J Med Chem 2006, 49, 6177-6196.