Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix

Genes and Development

Volumn 28, Issue 19, 2014, Pages 2134-2150

  Akkari, Leila ^a   Gocheva, Vasilena ^a   Kester, Jemila C ^a   Hunter, Karen E ^a   Quick, Marsha L ^a   Sevenich, Lisa ^a   Wang, Hao Wei ^a   Peters, Christoph ^b,c   Tang, Laura H ^a   Klimstra, David S ^a   Reinheckel, Thomas ^b,c   Joyce, Johanna A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Cell invasion; Cell migration; Protease; Tumor microenvironment

Indexed keywords

ARGININE; ASPARTIC ACID; CATHEPSIN X; GLYCINE; INTEGRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL; CARCINOGENESIS; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE TRANSFER; HISTOLOGY; HUMAN; MACROPHAGE; MOUSE; NONHUMAN; PANCREATIC NEUROENDOCRINE TUMOR; PROTEIN FUNCTION; PROTEIN ISOLATION; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; ENZYMOLOGY; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CATHEPSIN Z; CELL LINE, TUMOR; EXTRACELLULAR MATRIX; INTEGRINS; MACROPHAGES; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASMS;

EID: 84907507481     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.249599.114     Document Type: Article

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