Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages E6343-E6351

  Skinnider, Michael A ^a   Johnston, Chad W ^a   Edgar, Robyn E ^a   Dejong, Chris A ^a   Merwin, Nishanth J ^a   Rees, Philip N ^a   Magarvey, Nathan A ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Chemical space; Cheminformatics; Genome mining; Natural product discovery; Ribosomally synthesized natural product

Indexed keywords

NATURAL PRODUCT; RIBOSOMALLY SYNTHESIZED AND POSTTRANSLATIONALLY MODIFIED PEPTIDE; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; PEPTIDE;

ACCURACY; ALGORITHM; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL SPACE; CHEMICAL STRUCTURE; GENE CLUSTER; GENE SEQUENCE; GENETIC VARIABILITY; GENOME ANALYSIS; MICROBIAL GENOME; NONHUMAN; PEPTIDE ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STIGMATELLA AURANTIACA; STRUCTURE ANALYSIS; VALIDATION PROCESS; BIOLOGY; CLUSTER ANALYSIS; GENETICS; GENOMICS; MARKOV CHAIN; METABOLISM; PHYSIOLOGY; PROCEDURES; PROKARYOTIC CELL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REPRODUCIBILITY; RIBOSOME;

ALGORITHMS; BIOLOGICAL PRODUCTS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; GENOMICS; MARKOV CHAINS; PEPTIDES; PROKARYOTIC CELLS; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPRODUCIBILITY OF RESULTS; RIBOSOMES;

EID: 84991669536     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1609014113     Document Type: Article

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