Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 8, 2009, Pages 2549-2553

  Brown, Laura C Wieland ^a,b   Acker, Michael G ^b   Clardy, Jon ^b   Walsh, Christopher T ^b   Fischbach, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Biosynthesis; Natural products; Thiazolylpeptides

Indexed keywords

MICROCOCCIN P1; MICROCOCCIN P2; POLYPEPTIDE ANTIBIOTIC AGENT; THIOCILLIN ANTIBIOTIC AGENT; THIOCILLIN I; THIOCILLIN II; THIOCILLIN III; THIOCILLIN IV; UNCLASSIFIED DRUG; YM 266183; YM 266184;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS CEREUS; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OPEN READING FRAME; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; PROTEIN PROCESSING; RIBOSOME; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SEQUENCE; BACILLUS CEREUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, INSERTIONAL; OLIGOPEPTIDES; PEPTIDES; PROTEIN PROCESSING, POST-TRANSLATIONAL;

BACTERIA (MICROORGANISMS);

EID: 62449284698     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900008106     Document Type: Article

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