Knockdown of RIPK1 markedly exacerbates murine immune-mediated liver injury through massive apoptosis of hepatocytes, independent of necroptosis and inhibition of NF-kB

Journal of Immunology

Volumn 197, Issue 8, 2016, Pages 3120-3129

  Suda, Jo ^a   Dara, Lily ^a   Yang, Luoluo ^a,b   Aghajan, Mariam ^c   Song, Yong ^d   Kaplowitz, Neil ^a   Li, Zhang Xu ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c ISIS PHARMACEUTICALS   (United States)

^d YSL Bioprocess Development Co   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CASPASE 3; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN KINASE 3; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; LIPOPOLYSACCHARIDE; MLKL PROTEIN, MOUSE; NECROSTATIN-1; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, MOUSE; RIPK3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; HEPATITIS; IMMUNE MEDIATED INJURY; IMMUNE MEDIATED LIVER INJURY; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LIVER CELL; LIVER INJURY; MALE; MOUSE; NATURAL KILLER T CELL; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNOLOGY; METABOLISM; NECROSIS; PHYSIOLOGY; SIGNAL TRANSDUCTION; TOXIC HEPATITIS;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CHEMICAL AND DRUG INDUCED LIVER INJURY; HEPATOCYTES; IMIDAZOLES; INDOLES; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; NECROSIS; NF-KAPPA B; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84991478623     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600690     Document Type: Article

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