Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 40, 2014, Pages 14436-14441

  Roderick, Justine E ^a   Hermane, Nicole ^a   Zelic, Matija ^a   Simmons, Matthew J ^b   Polykratis, Apostolos ^c,d   Pasparakis, Manolis ^c,d   Kelliher, Michelle A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BIND Biosciences Inc   (United States)

^c Renal Division   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Hematopoietic failure; Programmed necrosis; Tumor necrosis factor

Indexed keywords

ANTIESTROGEN; AUTACOID; CYTOKINE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, MOUSE; RIPK3 PROTEIN, MOUSE; TAMOXIFEN; TUMOR NECROSIS FACTOR;

ANIMAL; APOPTOSIS; BLOOD; BONE MARROW; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; EPITHELIUM CELL; FLOW CYTOMETRY; GENETICS; HEMATOPOIETIC STEM CELL; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PHYSIOLOGY; SPLEEN; THYMUS; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; BONE MARROW; CELLS, CULTURED; CYTOKINES; EPITHELIAL CELLS; ESTROGEN ANTAGONISTS; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NECROSIS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SPLEEN; TAMOXIFEN; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907833409     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409389111     Document Type: Article

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