Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo

Journal of Hepatology

Volumn 55, Issue 6, 2011, Pages 1272-1280

  Schattenberg, Jörn M ^a   Zimmermann, Tim ^a   Wörns, Marcus ^a   Sprinzl, Martin F ^a   Kreft, Andreas ^a   Kohl, Tobias ^a   Nagel, Michael ^a   Siebler, Jürgen ^b   Bergkamen, Henning Schulze ^c   He, You Wen ^d   Galle, Peter R ^a   Schuchmann, Marcus ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bid; c FLIP; Caspase 8; CD95; Cell death; Concanavalin A; d Galactosamine LPS; JNK; Liver injury

Indexed keywords

ANTIBODY; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CONCANAVALIN A; DEATH RECEPTOR; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; GALACTOSAMINE; JO2 ANTIBODY; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE DELETION; IN VIVO STUDY; KNOCKOUT MOUSE; LIVER CELL; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; ANTHRACENES; ANTIGENS, CD95; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASES; CONCANAVALIN A; DRUG-INDUCED LIVER INJURY; FEMALE; GALACTOSAMINE; HEPATOCYTES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; RECEPTORS, DEATH DOMAIN;

EID: 81355149658     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.03.008     Document Type: Article

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