mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Immunity

Volumn 45, Issue 3, 2016, Pages 540-554

  Zeng, Hu ^a   Cohen, Sivan ^b   Guy, Cliff ^a   Shrestha, Sharad ^a   Neale, Geoffrey ^a   Brown, Scott A ^a   Cloer, Caryn ^a   Kishton, Rigel J ^b   Gao, Xia ^b   Youngblood, Ben ^a   Do, Mytrang ^c   Li, Ming O ^c   Locasale, Jason W ^b   Rathmell, Jeffrey C ^b,d   Chi, Hongbo ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1; IMMUNOGLOBULIN A; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR FKHR; GLUCOSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FOLLICULAR HELPER T CELL; GENETIC TRANSCRIPTION; GERMINAL CENTER; GLUCOSE METABOLISM; GLYCOLYSIS; HELPER CELL; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCTION; LIPOGENESIS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; GERMINAL CENTER; GLUCOSE; IMMUNITY, HUMORAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; TOR SERINE-THREONINE KINASES;

EID: 84990996523     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.08.017     Document Type: Article

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