Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling

Journal of Immunology

Volumn 173, Issue 8, 2004, Pages 5290-5297

  Curnow, S John ^a   Scheel Toellner, Dagmar ^a   Jenkinson, Will ^a   Raza, Karim ^a   Durrani, Omar M ^a   Faint, Jeff M ^a   Rauz, Saaeha ^a   Wloka, Kaska ^a   Pilling, Darrell ^a   Rose John, Stefan ^b   Buckley, Christopher D ^a   Murray, Philip I ^a   Salmon, Mike ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYTOKINE; FAS LIGAND; INTERFERON; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ADULT; AGED; APOPTOSIS; AQUEOUS HUMOR; ARTICLE; CATARACT EXTRACTION; CELL SURVIVAL; CONTROLLED STUDY; EYE INFLAMMATION; HOMEOSTASIS; HUMAN; HUMAN CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MALNUTRITION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UVEITIS;

EID: 6344247561     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.8.5290     Document Type: Article

References (46)

1. Forrester, J. V., and P. G. McMenamin. 1999. Immunopathogenic mechanisms in intraocular inflammation. Chem. Immunol. 73:159.
2. Streilein, J. W. 1999. Regional immunity and ocular immune privilege. Chem. Immunol. 73:11.
3. Taylor, A. W. 1999. Ocular immunosuppressive microenvironment. Chem. Immunol. 73:72.
4. Niederkorn, J. Y. 1999. Anterior chamber-associated immune deviation. Chem. Immunol. 73:59.
5. Griffith, T. S., X. Yu, J. M. Herndon, D. R. Green, and T. A. Ferguson. 1996. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5:7.
6. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1189.
7. Schmitz, I., A. Krueger, S. Baumann, H. Schulze-Bergkamen, P. H. Krammer, and S. Kirchhoff. 2003. An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death. J. Immunol. 171:2930.
8. Lenardo, M., K. M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17:221.
9. Akbar, A. N., and M. Salmon. 1997. Cellular environments and apoptosis: tissue microenvironments control activated T-cell death. Immunol. Today 18:72.
10. Marrack, P., and J. Kappler. 2004. Control of T cell viability. Annu. Rev. Immunol. 22:765.
11. Stuart, P. M., T. S. Griffith, N. Usui, J. Pepose, X. Yu, and T. A. Ferguson. 1997. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. J. Clin. Invest. 99:396.
12. Wahlsten, J. L., H. L. Gitchell, C. C. Chan, B. Wiggert, and R. R. Caspi. 2000. Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis. J. Immunol. 165:5480.
13. Dick, A. D., K. Siepmann, C. Dees, L. Duncan, C. Broderick, J. Liversidge, and J. V. Forrester. 1999. Fas-Fas ligand-mediated apoptosis within aqueous during idiopathic acute anterior uveitis. Invest. Ophthalmol. Vis. Sci. 40:2258.
14. Ohta, K., K. Norose, X. C. Wang, S. Ito, A. Yano, and K. Segawa. 1996. Apoptosis-related fas antigen on memory T cells in aqueous humor of uveitis patients. Curr. Eye Res. 15:299.
15. Sugita, S., C. Taguchi, H. Takase, K. Sagawa, J. Sueda, K. Fukushi, N. Hikita, T. Watanabe, K. Itoh, and M. Mochizuki. 2000. Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis. Br. J. Ophthalmol. 84:1130.
16. Chan, C. C., D. M. Matteson, Q. Li, S. M. Whitcup, and R. B. Nussenblatt. 1997. Apoptosis in patients with posterior uveitis. Arch. Ophthalmol. 115:1559.
17. S) gene expression. Eur. J. Immunol. 26:294.
18. Pilling, D., A. N. Akbar, J. Girdlestone, C. H. Orteu, N. J. Borthwick, N. Amft, D. Scheel-Toellner, C. D. Buckley, and M. Salmon. 1999. Interferon-β mediates stromal cell rescue of T cells from apoptosis. Eur. J. Immunol. 29:1041.
19. Teague, T. K., P. Marrack, J. W. Kappler, and A. T. Vella. 1997. IL-6 rescues resting mouse T cells from apoptosis. J. Immunol. 158:5791.
20. Teague, T. K., B. C. Schaefer, D. Hildeman, J. Bender, T. Mitchell, J. W. Kappler, and P. Marrack. 2000. Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling. J. Exp. Med. 191:915.
21. Rose-John, S., and P. C. Heinrich. 1994. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem. J. 300:281.
22. Hurst, S. M., T. S. Wilkinson, R. M. McLoughlin, S. Jones, S. Horiuchi, N. Yamamoto, S. Rose-John, G. M. Fuller, N. Topley, and S. A. Jones. 2001. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14:705.
23. Kallen, K. J. 2002. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim. Biophys. Acta 1592:323.
24. Jones, S. A., S. Horiuchi, N. Topley, N. Yamamoto, and G. M. Fuller. 2001. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 15:43.
25. Salmon, M., D. Scheel-Toellner, A. P. Huissoon, D. Pilling, N. Shamsadeen, H. Hyde, A. D. D'Angeac, P. A. Bacon, P. Emery, and A. N. Akbar. 1997. Inhibition of T cell apoptosis in the rheumatoid synovium. J. Clin. Invest. 99:439.
26. Atreya, R., J. Mudter, S. Finotto, J. Mullberg, T. Jostock, S. Wirtz, M. Schutz, B. Bartsch, M. Holtmann, C. Becker, et al. 2000. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat. Med. 6:583.
27. Hogan, M. D., S. J. Kimura, and P. Thygeson. 1959. Signs and symptoms of uveitis. I. Anterior uveitis. Am. J. Ophthalmol. 47:155.
28. + expression and decreased IL-10 in the anterior chamber in idiopathic uveitis. Invest. Ophthalmol. Vis. Sci. 40:2019.
29. Zamzami, N., P. Marchetti, M. Castedo, C. Zanin, J. L. Vayssiere, P. X. Petit, and G. Kroemer. 1995. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181:1661.
30. Vignali, D. A. 2000. Multiplexed particle-based flow cytometric assays. J. Immunol. Methods 243:243.
31. Wang, X. C., K. Norose, A. Yano, K. Ohta, and K. Segawa. 1995. Two-color flow cytometric analysis of activated T lymphocytes in aqueous humor of patients with endogenous vs. exogenous uveitis. Curr. Eye Res. 14:425.
32. Peters, M., G. Blinn, F. Solem, M. Fischer, K. H. Meyer zum Buschenfelde, and S. Rose-John. 1998. In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6. J. Immunol. 161:3575.
33. Griffith, T. S., and T. A. Ferguson. 1997. The role of FasL-induced apoptosis in immune privilege. Immunol. Today 18:240.
34. Ferguson, T. A., and T. S. Griffith. 1997. A vision of cell death: insights into immune privilege. Immunol. Rev. 156:167.
35. Rieux-Laucat, F., S. Blachere, S. Danielan, J. P. De Villartay, M. Oleastro, E. Solary, B. Bader-Meunier, P. Arkwright, C. Pondare, F. Bernaudin, et al. 1999. Lymphoproliferative syndrome with autoimmunity: a possible genetic basis for dominant expression of the clinical manifestations. Blood 94:2575.
36. D'Orazio, T. J., B. M. DeMarco, E. S. Mayhew, and J. Y. Niederkorn. 1999. Effect of aqueous humor on apoptosis of inflammatory cell types. Invest. Ophthalmol. Vis. Sci. 40:1418.
37. Yang, P., J. R. Smith, K. S. Damodar, S. R. Planck, and J. T. Rosenbaum. 2003. Visualization of cell death in vivo during murine endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 44:1993.
38. Smith, J. R., P. H. Hart, S. D. Standfield, D. J. Coster, S. J. Wing, and K. A. Williams. 2000. Apoptosis is a prominent feature of acute anterior uveitis in the Fischer 344 rat. Br. J. Ophthalmol. 84:205.
39. Sueda, J., N. Hikita, M. Mochizuki, A. Jimi, and M. Kojiro. 2000. Kinetics of apoptotic cells in experimental autoimmune uveoretinitis. Invest. Ophthalmol. Vis. Sci. 41:799.
40. + T cells occurs in experimental autoimmune anterior uveitis (EAAU). Clin. Exp. Immunol. 118:357.
41. Sotozono, C., Y. Sano, T. Suzuki, R. Tada, T. Ikeda, S. Nagata, and S. Kinoshita. 2000. Soluble Fas ligand expression in the ocular fluids of uveitis patients. Curr. Eye Res. 20:54.
42. Opferman, J. T., and S. J. Korsmeyer. 2003. Apoptosis in the development and maintenance of the immune system. Nat. Immunol. 4:410.
43. Akbar, A. N., J. M. Lord, and M. Salmon. 2000. IFN-α and IFN-β: a link between immune memory and chronic inflammation. Immunol. Today 21:337.
44. Ohta, K., B. Wiggert, S. Yamagami, A. W. Taylor, and J. W. Streilein. 2000. Analysis of immunomodulatory activities of aqueous humor from eyes of mice with experimental autoimmune uveitis. J. Immunol. 164:1185.
45. Ohta, K., S. Yamagami, A. W. Taylor, and J. W. Streilein. 2000. IL-6 antagonizes TGF-β and abolishes immune privilege in eyes with endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 41:2591.
46. Desgeorges, A., C. Gabay, P. Silacci, D. Novick, P. Roux-Lombard, G. Grau, J. M. Dayer, T. Vischer, and P. A. Guerne. 1997. Concentrations and origins of soluble interleukin 6 receptor-α in serum and synovial fluid. J. Rheumatol. 24:1510.