Inflammation perturbs the IL-7 axis, promoting senescence and exhaustion that broadly characterize immune failure in treated HIV infection

Journal of Acquired Immune Deficiency Syndromes

Volumn 71, Issue 5, 2016, Pages 483-492

  Shive, Carey L ^a   Clagett, Brian ^a   McCausland, Marie R ^a   Mudd, Joseph C ^b   Funderburg, Nicholas T ^c   Freeman, Michael L ^a   Younes, Souheil Antoine ^a   Ferrari, Brian M ^a   Rodriguez, Benigno ^a,d   McComsey, Grace A ^d   Calabrese, Leonard H ^e   Sieg, Scott F ^a   Lederman, Michael M ^a,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

Author keywords

HIV; IL 1 ; IL 6; IL 7; Immune failure; Senescence

Indexed keywords

CD57 ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; KI 67 ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL 2; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOLOGICAL MARKER; INTERLEUKIN 7 RECEPTOR ALPHA; PROTEIN BAD;

ANTIVIRAL THERAPY; ARTICLE; BLOOD LEVEL; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL METABOLISM; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOSENESCENCE; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADULT; BLOOD; CASE CONTROL STUDY; CD4+ T LYMPHOCYTE; CELL AGING; CELL DEATH; FEMALE; IMMUNOLOGY; IMMUNOPHENOTYPING; MALE; METABOLISM; PHYSIOLOGY; TREATMENT FAILURE;

ADULT; ANTI-HIV AGENTS; ANTIGENS, CD57; BCL-ASSOCIATED DEATH PROTEIN; BIOMARKERS; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL AGING; CELL DEATH; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-7; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MALE; TREATMENT FAILURE;

EID: 84949009807     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000913     Document Type: Article

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