Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

Nature Communications

Volumn 7, Issue , 2016, Pages

  Fang, Nancy N ^a   Zhu, Mang ^a   Rose, Amalia ^a   Wu, Kuen Phon ^b   Mayor, Thibault ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSOLIC MISFOLDED PROTEIN; DEUBIQUITINASE; PROTEASOME; PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; ESCRT PROTEIN; HEAT SHOCK PROTEIN; PEPTIDE; PROTEIN BINDING; PROTEINASE; RECOMBINANT PROTEIN; RSP5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN-NALPHA-PROTEIN HYDROLASE; UBP3 PROTEIN, S CEREVISIAE; WBP2 PROTEIN, HUMAN;

BIOACTIVITY; BIODEGRADATION; GENETIC ANALYSIS; MEMBRANE; PLASMA; PROTEIN; QUALITY CONTROL; TEMPERATURE TOLERANCE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HEAT STRESS; NONHUMAN; PROTEIN QUALITY; SACCHAROMYCES CEREVISIAE; CHEMISTRY; CYTOSOL; HUMAN; METABOLISM; PLASMID; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; TEMPERATURE; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CYTOSOL; DEUBIQUITINATING ENZYMES; ENDOPEPTIDASES; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; HEAT-SHOCK PROTEINS; HUMANS; PEPTIDES; PLASMIDS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEOLYSIS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TEMPERATURE; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84990861120     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12907     Document Type: Article

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