The -4 Phenylalanine Is Required for Substrate Ubiquitination Catalyzed by HECT Ubiquitin Ligases

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18935-18943

  Salvat, Catherine ^a   Wang, Guangli ^a,b   Dastur, Anahita ^a   Lyon, Nancy ^a   Huibregtse, Jon M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b Laureate Pharma   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PROTEINS; SUBSTRATES;

LIGASES; REACTION CYCLES;

BIOCHEMISTRY;

ALANINE; AMINO ACID; CYSTEINE; HECT UBIQUITIN LIGASE; LYSINE DERIVATIVE; PHENYLALANINE; PROTEIN; PROTEIN E6AP; PROTEIN RSP5P; THIOESTER; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; ENZYME ACTIVE SITE; HAPPY PUPPET SYNDROME; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; STOP CODON; UBIQUITINATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CARRIER PROTEINS; CATALYSIS; CONSERVED SEQUENCE; HUMANS; PHENYLALANINE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 2442536052     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312201200     Document Type: Article

References (28)

1. Pickart, C. M. (2001) Anna. Rev. Biochem. 70, 503-533
2. Huibregtse, J. M., Scheffner, M., Beaudenon, S., and Howley, P. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2563-2567
3. Scheffner, M., Nuber, U., and Huibregtse, J. M. (1995) Nature 373, 81-83
4. Huibregtse, J. M., Scheffner, M., and Howley, P. M. (1994) Cold Spring Harb. Symp. Quant. Biol. 59, 237-245
5. Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. (1993) Cell 75, 495-505
6. Munger, K., and Howley, P. M. (2002) Virus Res. 89, 213-228
7. Kumar, S., Talis, A. L., and Howley, P. M. (1999) J. Biol. Chem. 274, 18785-18792
8. Oda, H., Kumar, S., and Howley, P. M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9557-9562
9. Kuhne, C., and Banks, L. (1998) J. Biol. Chem. 273, 34302-34309
10. Matsuura, T., Sutcliffe, J. S., Fang, P., Galjaard, R. J., Jiang, Y. H., Benton, C. S., Rommens, J. M., and Beaudet, A. L. (1997) Nat. Genet. 15, 74-77
11. Kishino, T., Lalande, M., and Wagstaff, J. (1997) Nat. Genetics 15, 70-73
12. Vu, T. H., and Hoffman, A. R. (1997) Nat. Genet. 17, 12-13
13. Albrecht, U., Sutcliffe, J. S., Cattanach, B. M., Beechey, C. V., Armstrong, D., Eichele, G., and Beaudet, A. L. (1997) Nat. Genetics 17, 75-78
14. Macias, M. J., Wiesner, S., and Sudol, M. (2002) FEBS Lett. 513, 30-37
15. Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., and Thomsen, G. H. (1999) Nature 400, 687-693
16. Huibregtse, J. M., Yang, J. C., and Beaudenon, S. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3656-3661
17. Hoppe, T., Matuschewski, K., Rape, M., Schlenker, S., Ulrich, H. D., and Jentsch, S. (2000) Cell 102, 577-586
18. Wang, G., Yang, J., and Huibregtse, J. M. (1999) Mol. Cell. Biol. 19, 342-352
19. Huang, L., Kinnucan, E., Wang, G., Beaudenon, S., Howley, P. M., Huibregtse, J. M., and Pavletich, N. P. (1999) Science 286, 1321-1326
20. Verdecia, M. A., Joazeiro, C. A., Wells, N. J., Ferrer, J. L., Bowman, M. E., Hunter, T., and Noel, J. P. (2003) Mol. Cell 11, 249-259
21. Yamamoto, Y., Huibregtse, J. M., and Howley, P. M. (1997) Genomics 41, 263-266
22. Hamilton, K. S., Ellison, M. J., Barber, K. R., Williams, R. S., Huzil, J. T., McKenna, S., Ptak, C., Glover, M., and Shaw, G. S. (2001) Structure (Cambridge) 9, 897-904
23. Girod, P. A., Carpenter, T. B., van Nocker, S., Sullivan, M. L., and Vierstra, R. D. (1993) Plant J. 3, 545-552
24. Fang, P., Lev-Lehman, E., Tsai, T. F., Matsuura, T., Benton, C. S., Sutcliffe, J. S., Christian, S. L., Kubota, T., Halley, D. J., Meijers-Heijboer, H., Langlois, S., Graham, J. M., Jr., Beuten, J., Willems, P. J., Ledbetter, D. H., and Beaudet, A. L. (1999) Hum. Mol. Genet. 8, 129-135
25. Chen, H. I., Einbond, A., Kwak, S. J., Linn, H., Koepf, E., Peterson, S., Kelly, J. W., and Sudol, M. (1997) J. Biol. Chem. 272, 17070-17077
26. Beal, R., Deveraux, Q., Xia, G., Rechsteiner, M., and Pickart, C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 861-866
27. Kishino, T., and Wagstaff, J. (1998) Genomics 47, 101-107
28. Puig, O., Caspary, F., Rigaut, G., Rutz, B., Bouveret, E., Bragado-Nilsson, E., Wilm, M., and Seraphin, B. (2001) Methods 24, 218-229