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Volumn 45, Issue 1, 2016, Pages 83-93

MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EOS PROTEIN; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; L SELECTIN; LYMPHOID ENHANCER FACTOR 1; MICRORNA; MICRORNA 17; MICRORNA 17 92; PROTEIN; SATB1 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG; CARRIER PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; MIRN17-92 MICRORNA, MOUSE; NERVE PROTEIN; ZFPN1A4 PROTEIN, MOUSE;

EID: 84990836182     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.06.022     Document Type: Article
Times cited : (87)

References (55)
  • 1
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T.B., Oukka, M., Weiner, H.L., Kuchroo, V.K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006), 235–238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 3
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway
    • Brock, M., Trenkmann, M., Gay, R.E., Michel, B.A., Gay, S., Fischler, M., Ulrich, S., Speich, R., Huber, L.C., Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104 (2009), 1184–1191.
    • (2009) Circ. Res. , vol.104 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3    Michel, B.A.4    Gay, S.5    Fischler, M.6    Ulrich, S.7    Speich, R.8    Huber, L.C.9
  • 4
    • 51049089025 scopus 로고    scopus 로고
    • The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
    • Chong, M.M., Rasmussen, J.P., Rudensky, A.Y., Littman, D.R., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J. Exp. Med. 205 (2008), 2005–2017.
    • (2008) J. Exp. Med. , vol.205 , pp. 2005-2017
    • Chong, M.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3    Littman, D.R.4
  • 6
    • 84861424521 scopus 로고    scopus 로고
    • An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
    • Darce, J., Rudra, D., Li, L., Nishio, J., Cipolletta, D., Rudensky, A.Y., Mathis, D., Benoist, C., An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 36 (2012), 731–741.
    • (2012) Immunity , vol.36 , pp. 731-741
    • Darce, J.1    Rudra, D.2    Li, L.3    Nishio, J.4    Cipolletta, D.5    Rudensky, A.Y.6    Mathis, D.7    Benoist, C.8
  • 7
    • 84881423363 scopus 로고    scopus 로고
    • microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis
    • de Kouchkovsky, D., Esensten, J.H., Rosenthal, W.L., Morar, M.M., Bluestone, J.A., Jeker, L.T., microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. J. Immunol. 191 (2013), 1594–1605.
    • (2013) J. Immunol. , vol.191 , pp. 1594-1605
    • de Kouchkovsky, D.1    Esensten, J.H.2    Rosenthal, W.L.3    Morar, M.M.4    Bluestone, J.A.5    Jeker, L.T.6
  • 11
    • 84866018476 scopus 로고    scopus 로고
    • Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation
    • Gao, Z., Gao, Y., Li, Z., Chen, Z., Lu, D., Tsun, A., Li, B., Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation. Int. J. Clin. Exp. Pathol. 5 (2012), 626–633.
    • (2012) Int. J. Clin. Exp. Pathol. , vol.5 , pp. 626-633
    • Gao, Z.1    Gao, Y.2    Li, Z.3    Chen, Z.4    Lu, D.5    Tsun, A.6    Li, B.7
  • 12
    • 0029411144 scopus 로고
    • Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation
    • Gijbels, K., Brocke, S., Abrams, J.S., Steinman, L., Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol. Med. 1 (1995), 795–805.
    • (1995) Mol. Med. , vol.1 , pp. 795-805
    • Gijbels, K.1    Brocke, S.2    Abrams, J.S.3    Steinman, L.4
  • 14
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou, J., Wang, P., Lin, L., Liu, X., Ma, F., An, H., Wang, Z., Cao, X., MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J. Immunol. 183 (2009), 2150–2158.
    • (2009) J. Immunol. , vol.183 , pp. 2150-2158
    • Hou, J.1    Wang, P.2    Lin, L.3    Liu, X.4    Ma, F.5    An, H.6    Wang, Z.7    Cao, X.8
  • 15
    • 81555196345 scopus 로고    scopus 로고
    • Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
    • Jiang, S., Li, C., Olive, V., Lykken, E., Feng, F., Sevilla, J., Wan, Y., He, L., Li, Q.J., Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood 118 (2011), 5487–5497.
    • (2011) Blood , vol.118 , pp. 5487-5497
    • Jiang, S.1    Li, C.2    Olive, V.3    Lykken, E.4    Feng, F.5    Sevilla, J.6    Wan, Y.7    He, L.8    Li, Q.J.9
  • 16
    • 64849100152 scopus 로고    scopus 로고
    • Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
    • Kohlhaas, S., Garden, O.A., Scudamore, C., Turner, M., Okkenhaug, K., Vigorito, E., Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J. Immunol. 182 (2009), 2578–2582.
    • (2009) J. Immunol. , vol.182 , pp. 2578-2582
    • Kohlhaas, S.1    Garden, O.A.2    Scudamore, C.3    Turner, M.4    Okkenhaug, K.5    Vigorito, E.6
  • 20
    • 77749260581 scopus 로고    scopus 로고
    • Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients
    • Lindberg, R.L., Hoffmann, F., Mehling, M., Kuhle, J., Kappos, L., Altered expression of miR-17-5p in CD4+ lymphocytes of relapsing-remitting multiple sclerosis patients. Eur. J. Immunol. 40 (2010), 888–898.
    • (2010) Eur. J. Immunol. , vol.40 , pp. 888-898
    • Lindberg, R.L.1    Hoffmann, F.2    Mehling, M.3    Kuhle, J.4    Kappos, L.5
  • 21
    • 51049110261 scopus 로고    scopus 로고
    • Dicer-dependent microRNA pathway safeguards regulatory T cell function
    • Liston, A., Lu, L.F., O'Carroll, D., Tarakhovsky, A., Rudensky, A.Y., Dicer-dependent microRNA pathway safeguards regulatory T cell function. J. Exp. Med. 205 (2008), 1993–2004.
    • (2008) J. Exp. Med. , vol.205 , pp. 1993-2004
    • Liston, A.1    Lu, L.F.2    O'Carroll, D.3    Tarakhovsky, A.4    Rudensky, A.Y.5
  • 24
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • Miyao, T., Floess, S., Setoguchi, R., Luche, H., Fehling, H.J., Waldmann, H., Huehn, J., Hori, S., Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36 (2012), 262–275.
    • (2012) Immunity , vol.36 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3    Luche, H.4    Fehling, H.J.5    Waldmann, H.6    Huehn, J.7    Hori, S.8
  • 25
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell, R.M., Rao, D.S., Chaudhuri, A.A., Baltimore, D., Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10 (2010), 111–122.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 26
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea, J.J., Paul, W.E., Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327 (2010), 1098–1102.
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 27
    • 2342449399 scopus 로고    scopus 로고
    • Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma
    • Ota, A., Tagawa, H., Karnan, S., Tsuzuki, S., Karpas, A., Kira, S., Yoshida, Y., Seto, M., Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 64 (2004), 3087–3095.
    • (2004) Cancer Res. , vol.64 , pp. 3087-3095
    • Ota, A.1    Tagawa, H.2    Karnan, S.3    Tsuzuki, S.4    Karpas, A.5    Kira, S.6    Yoshida, Y.7    Seto, M.8
  • 29
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., Medzhitov, R., Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299 (2003), 1033–1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 36
    • 65649131286 scopus 로고    scopus 로고
    • IL-6 and TNF-alpha synergistically inhibit allograft acceptance
    • Shen, H., Goldstein, D.R., IL-6 and TNF-alpha synergistically inhibit allograft acceptance. J. Am. Soc. Nephrol. 20 (2009), 1032–1040.
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 1032-1040
    • Shen, H.1    Goldstein, D.R.2
  • 37
    • 39749110083 scopus 로고    scopus 로고
    • Small non-coding RNAs in animal development
    • Stefani, G., Slack, F.J., Small non-coding RNAs in animal development. Nat. Rev. Mol. Cell Biol. 9 (2008), 219–230.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 219-230
    • Stefani, G.1    Slack, F.J.2
  • 38
    • 27644570319 scopus 로고    scopus 로고
    • A microRNA cluster as a target of genomic amplification in malignant lymphoma
    • Tagawa, H., Seto, M., A microRNA cluster as a target of genomic amplification in malignant lymphoma. Leukemia 19 (2005), 2013–2016.
    • (2005) Leukemia , vol.19 , pp. 2013-2016
    • Tagawa, H.1    Seto, M.2
  • 40
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
    • Tang, Q., Bluestone, J.A., The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9 (2008), 239–244.
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 41
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S., Fagarasan, S., Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323 (2009), 1488–1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6    Hori, S.7    Fagarasan, S.8
  • 42
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., Stockinger, B., TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006), 179–189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 44
    • 84942512521 scopus 로고    scopus 로고
    • MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice
    • Wu, Y., Heinrichs, J., Bastian, D., Fu, J., Nguyen, H., Schutt, S., Liu, Y., Jin, J., Liu, C., Li, Q.J., et al. MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. Blood 126 (2015), 1314–1323.
    • (2015) Blood , vol.126 , pp. 1314-1323
    • Wu, Y.1    Heinrichs, J.2    Bastian, D.3    Fu, J.4    Nguyen, H.5    Schutt, S.6    Liu, Y.7    Jin, J.8    Liu, C.9    Li, Q.J.10
  • 46
    • 34249799285 scopus 로고    scopus 로고
    • Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    • Xu, L., Kitani, A., Fuss, I., Strober, W., Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J. Immunol. 178 (2007), 6725–6729.
    • (2007) J. Immunol. , vol.178 , pp. 6725-6729
    • Xu, L.1    Kitani, A.2    Fuss, I.3    Strober, W.4
  • 49
    • 47249166438 scopus 로고    scopus 로고
    • Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    • Zheng, S.G., Wang, J., Horwitz, D.A., Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 180 (2008), 7112–7116.
    • (2008) J. Immunol. , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 55
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: of mice and men
    • Ziegler, S.F., FOXP3: of mice and men. Annu. Rev. Immunol. 24 (2006), 209–226.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 209-226
    • Ziegler, S.F.1


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