Modelling proteins' hidden conformations to predict antibiotic resistance

Nature Communications

Volumn 7, Issue , 2016, Pages

  Hart, Kathryn M ^a   Ho, Chris M W ^a   Dutta, Supratik ^b   Gross, Michael L ^b   Bowman, Gregory R ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE TEM 1; BETA LACTAMASE TEM 52; CEFOTAXIMASE; CEFOTAXIME; PENICILLIN G; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BETA-LACTAMASE TEM-1; PROTEIN BINDING; SOLVENT;

ANTIBIOTIC RESISTANCE; BACTERIUM; DRUG DEVELOPMENT; ENZYME ACTIVITY; MARKOV CHAIN; MODEL VALIDATION; PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATIONAL STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME SPECIFICITY; HIDDEN MARKOV MODEL; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MIC90; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PREDICTIVE VALUE; PROTEIN CONFORMATION; PROTEIN POLYMORPHISM; ALGORITHM; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; MARKOV CHAIN; MUTATION; SENSITIVITY AND SPECIFICITY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; CEFOTAXIME; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; KINETICS; MARKOV CHAINS; MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SOLVENTS;

EID: 84990832618     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12965     Document Type: Article

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