Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

Cell Reports

Volumn 16, Issue 9, 2016, Pages 2359-2372

  Schmidt, Søren Fisker ^a   Madsen, Jesper Grud Skat ^a,b   Frafjord, Kari Østerli ^a   Poulsen, Lars la Cour ^a   Salö, Sofia ^c   Boergesen, Michael ^a   Loft, Anne ^a   Larsen, Bjørk Ditlev ^a   Madsen, Maria Stahl ^a   Holst, Jens Juul ^b   Maechler, Pierre ^d   Dalgaard, Louise Torp ^c   Mandrup, Susanne ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ROSKILDE UNIVERSITY   (Denmark)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

ChIP seq; ChREBP; glucose; metabolism; pancreatic cells; proliferation; RNA seq; ROR ; cells

Indexed keywords

CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; GLUCOSE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CELL CYCLE PROTEIN; RORC PROTEIN, RAT; WBSCR14 PROTEIN, RAT;

ADULT; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENHANCER REGION; GAIN OF FUNCTION MUTATION; GENE INDUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENOMICS; GLUCOSE METABOLISM; LIPID METABOLISM; LOSS OF FUNCTION MUTATION; NONHUMAN; NUCLEAR REPROGRAMMING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS; ANIMAL; CELL LINE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENHANCER ELEMENTS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; GLUCOSE; INSULIN-SECRETING CELLS; METABOLIC NETWORKS AND PATHWAYS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROMOTER REGIONS, GENETIC; RATS; TRANSCRIPTION, GENETIC;

EID: 84990212640     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.07.063     Document Type: Article

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