Inhibition of beta cell growth and function by bone morphogenetic proteins

Diabetologia

Volumn 57, Issue 12, 2014, Pages 2546-2554

  Bruun, Christine ^a,b   Christensen, Gitte L ^c   Jacobsen, Marie L B ^c   Kanstrup, Marianne B ^a   Jensen, Pernille R ^c   Fjordvang, Helle ^a,c   Mandrup Poulsen, Thomas ^a,c,d   Billestrup, Nils ^a,c  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Beta cell proliferation; Bone morphogenetic protein; Cell cycle; Glucose stimulated insulin secretion Inhibitor of DNA binding

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXY 1 METHYLTETRALIN; ACTIVIN A; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; EDOXUDINE; GLUCOSE; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; INHIBITOR OF DIFFERENTIATION 4; INTERLEUKIN 1BETA; NUCLEIC ACID BINDING PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG; INSULIN;

ADULT; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE DELETION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; INSULIN; INSULIN-SECRETING CELLS; MICE; RATS; SIGNAL TRANSDUCTION;

EID: 84926633380     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3384-8     Document Type: Article

References (43)

1. Bonner-Weir S, Weir GC (2005) New sources of pancreatic beta-cells. Nat Biotechnol 23:857–861
2. Inada A, Bonner-Weir S, Toschi E (2006) How can we get more beta cells? Curr Diab Rep 6:96–101
3. Nir T, Dor Y (2005) How to make pancreatic beta cells—prospects for cell therapy in diabetes. Curr Opin Biotechnol 16:524–529
4. Vasavada RC, Gonzalez-Pertusa JA, Fujinaka Y et al (2006) Growth factors and beta cell replication. Int J Biochem Cell Biol 38:931–950
5. El OA, Kawamori D, Dirice E et al (2013) Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 3:401–410
6. Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic & beta; cell proliferation. Cell 153:747–758
7. Chung WS, Andersson O, Row R et al (2010) Suppression of Alk8-mediated Bmp signaling cell-autonomously induces pancreatic beta-cells in zebrafish. Proc Natl Acad Sci U S A 107:1142–1147
8. Krishnamurthy J, Ramsey MR, Ligon KL et al (2006) p16(INK4a) induces an age-dependent decline in islet regenerative potential. Nature 443:453–457
9. Parsons JA, Brelje TC, Sorenson RL (1992) Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. Endocrinology 130:1459–1466
10. Schulz TJ, Tseng YH (2009) Emerging role of bone morpho-genetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 20:523–531
11. Wandzioch E, Zaret KS (2009) Dynamic signaling network for the specification of embryonic pancreas and liver progenitors. Science 324:1707–1710
12. Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA et al (2006) Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 27:356–370
13. Van-Assche FA, Aerts L, De-Prins F (1978) A morphological study of the endocrine pancreas in human pregnancy. Br J Obstet Gynaecol 85:818–820
14. Saisho Y, Butler AE, Manesso E et al (2013) β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 36: 111–117
15. Massague J (2000) How cells read TGF-beta signals. Nature reviews. Mol Cell Biol 1:169–178
16. Boström KI, JumabayM,MatveyenkoA,Nicholas SB, YaoY(2011) Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 108:446–457
17. Koga M, Engberding N, Dikalova AE et al (2013) The bone mor-phogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice. Am J Physiol Heart Circ Physiol 305: H747–H755
18. Nett PC, Ortmann J, Celeiro J et al (2006) Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus. Life Sci 78:2213–2218
19. San Martin A, Du P, Dikalova A et al (2007) Reactive oxygen species-selective regulation of aortic inflammatory gene expression in type 2 diabetes. Am J Physiol Heart Circ Physiol 292:H2073– H2082
20. Dichmann DS, Miller CP, Jensen J et al (2003) Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn 226: 663–674
21. Goulley J, Dahl U, Baeza N et al (2007) BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab 5:207–219
22. Zhang YQ, Zhang H, Maeshima A et al (2002) Up-regulation of the expression of activins in the pancreatic duct by reduction of the beta-cell mass. Endocrinology 143:3540–3547
23. Eizirik DL, Sammeth M, Bouckenooghe T et al (2012) The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet 8:e1002552
24. Moore F, Naamane N, Colli ML et al (2011) STAT1 is a master regulator of pancreatic beta-cell apoptosis and islet inflammation. J Biol Chem 286:929–941
25. Harmon EB, Apelqvist AA, Smart NG et al (2004) GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development. Development 131:6163–6174
26. Hua H, Zhang YQ, Dabernat S et al (2006) BMP4 regulates pancreatic progenitor cell expansion through Id2. J Biol Chem 281:13574–13580
27. Rane SG, Lee JH, Lin HM (2006) Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease. Cytokine Growth Factor Rev 17:107–119
28. Scott GJ, Ray MK, Ward T et al (2009) Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling. Genesis 47:385–391
29. Akerfeldt MC, Laybutt DR (2011) Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes 60:2506–2514
30. Brunstedt J (1980) Rapid isolation of functionally intact pancreatic islets from mice and rats by percollTM gradient centrifucation. Diabete Metab 6:87–89
31. Cucak H, Grunnet LG, Rosendahl A (2014) Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. J Leukoc Biol 95:149–160
32. Parnaud G, Bosco D, Berney T et al (2008) Proliferation of sorted human and rat beta cells. Diabetologia 51:91–100
33. Frobøse H, Rønn SG, Heding PE et al (2006) Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. Mol Endocrinol 20:1587–1596
34. Poulsen F, Jensen KB (2007) A luminescent oxygen channeling immunoassay for the determination of insulin in human plasma. J Biomol Screen 12:240–247
35. Miyazono K, Miyazawa K (2002) Id: a target of BMP signaling. Sci STKE:e40
36. Brun T, Franklin I, StOnge L et al (2004) The diabetes-linked transcription factor PAX4 promotes beta-cell proliferation and survival in rat and human islets. J Cell Biol 167:1123–1135
37. Kim SK, MacDonald RJ (2002) Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 12:540–547
38. Brown ML, Kimura F, Bonomi LM et al (2011) Differential synthesis and action of TGF-superfamily ligands in mouse and rat islets. Islets 3:367–375
39. Lasorella A, Uo T, Iavarone A (2001) Id proteins at the cross-road of development and cancer. Oncogene 20:8326–8333
40. Gu C, Stein GH, Pan N et al (2010) Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab 11: 298–310
41. Hussein KA, Choksi K, Akeel S et al (2014) Bone morphogenetic protein 2: a potential new player in the pathogenesis of diabetic retinopathy. Exp Eye Res 125:79–88
42. Tominaga T, Abe H, Ueda O et al (2011) Activation of bone mor-phogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy. J Biol Chem 286:20109–20116
43. Derwall M, Malhotra R, Lai CS et al (2012) Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 32:613–622