Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity

Diabetologia

Volumn 55, Issue 6, 2012, Pages 1783-1796

  Poungvarin, N ^b   Lee, J K ^a   Yechoor, V K ^a   Li, M V ^a   Assavapokee, T ^a   Suksaranjit, P ^a   Thepsongwajja, J J ^a   Saha, P K ^a   Oka, K ^a   Chan, L ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

^c ST LUKE S EPISCOPAL HOSPITAL   (United States)

Author keywords

Beta cell apoptosis; Beta cell dysfunction; ChREBP; Glucotoxicity; MLXIPL; TXNIP

Indexed keywords

ADENOVIRUS VECTOR; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; FATTY ACID SYNTHASE; INSULIN; THIOREDOXIN INTERACTING PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN, MOUSE; GLUCOSE; NUCLEAR PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CELL DAMAGE; CELL LEVEL; CELL PROTECTION; CLINICAL FEATURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; GLUCOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INTRACELLULAR SIGNALING; LIPID STORAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TARGETING; REVIEW; TARGET CELL; ANIMAL; ARTICLE; C57BL MOUSE; CELL LINE; DRUG EFFECT; GENETICS; GLUCOSE TOLERANCE TEST; LASER CAPTURE MICRODISSECTION; METABOLISM; PANCREAS ISLET;

ANIMALS; APOPTOSIS; CELL LINE; GLUCOSE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LASER CAPTURE MICRODISSECTION; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

EID: 84865418265     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2506-4     Document Type: Review

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