Identification of insulin as a novel retinoic acid receptor-related orphan receptor α target gene

FEBS Letters

Volumn 588, Issue 6, 2014, Pages 1071-1079

  Kuang, Jiangying ^a   Hou, Xiaoming ^a   Zhang, Jinlong ^a   Chen, Yulong ^a   Su, Zhiguang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Gene transcription; Insulin; Promoter; Retinoic acid receptor related orphan receptor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR ALPHA AGONIST; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; LUCIFERASE ASSAY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

GENE TRANSCRIPTION; INSULIN; PROMOTER; RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR Α;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CONSENSUS SEQUENCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; INSULIN; MAF TRANSCRIPTION FACTORS, LARGE; MALE; MICE; MICE, INBRED C57BL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; PANCREAS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RESPONSE ELEMENTS; TRANS-ACTIVATORS;

EID: 84896087262     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.02.029     Document Type: Article

References (50)

1. L. Koch, F.T. Wunderlich, J. Seibler, A.C. Könner, B. Hampel, S. Irlenbusch, G. Brabant, C.R. Kahn, F. Schwenk, and J.C. Brüning Central insulin action regulates peripheral glucose and fat metabolism in mice J. Clin. Invest. 118 2008 2132
2. S. Del Prato, G. Enzi, S. Vigili de Kreutzenberg, G. Lisato, A. Riccio, L. Maifreni, E. Iori, F. Zurlo, G. Sergi, and A. Tiengo Insulin regulation of glucose and lipid metabolism in massive obesity Diabetologia 33 1990 228 236
3. S. Seino, T. Shibasaki, and K. Minami Dynamics of insulin secretion and the clinical implications for obesity and diabetes J. Clin. Invest. 121 2011 2118
4. D. Boam, A. Clark, and K. Docherty Positive and negative regulation of the human insulin gene by multiple trans-acting factors J. Biol. Chem. 265 1990 8285 8296
5. K. Ohneda, R.G. Mirmira, J. Wang, J.D. Johnson, and M.S. German The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter Mol Cel Biol. 20 2000 900 911
6. L. Zhao, M. Guo, T.-A. Matsuoka, D.K. Hagman, S.D. Parazzoli, V. Poitout, and R. Stein The islet β cell-enriched MafA activator is a key regulator of insulin gene transcription J. Biol. Chem. 280 2005 11887 11894
7. S. Aramata, S.-I. Han, K. Yasuda, and K. Kataoka Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA, Beta2, and Pdx1 Biochim. Biophys. Acta 1730 2005 41
8. F.J. Naya, C. Stellrecht, and M.-J. Tsai Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor Genes Dev. 9 1995 1009 1019
9. J. Ham, and M. Parker Regulation of gene expression by nuclear hormone receptors Curr. Opin. Cell Biol. 1 1989 503 511
10. A. Aranda, and A. Pascual Nuclear hormone receptors and gene expression Physiol. Rev. 81 2001 1269 1304
11. M. Pawlak, P. Lefebvre, and B. Staels General molecular biology and architecture of nuclear receptors Curr. Top. Med. Chem. 12 2012 486 504
12. G.A. Francis, E. Fayard, F. Picard, and J. Auwerx Nuclear receptors and the control of metabolism Annu. Rev. Physiol. 65 2003 261 311
13. S.W. Beaven, and P. Tontonoz Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia Annu. Rev. Med. 57 2006 313 329
14. J. Sonoda, L. Pei, and R.M. Evans Nuclear receptors: decoding metabolic disease FEBS Lett. 582 2008 2 9
15. H.J. Huang, and I.G. Schulman Regulation of metabolism by nuclear hormone receptors Prog. Mol. Biol. Transl. Sci. 87 2009 1 51
16. V. Giguere, M. Tini, G. Flock, E. Ong, R.M. Evans, and G. Otulakowski Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors Genes Dev. 8 1994 538 553
17. N. Vu-Dac, P. Gervois, T. Grötzinger, P. De Vos, K. Schoonjans, J.-C. Fruchart, J. Auwerx, J. Mariani, A. Tedgui, and B. Staels Transcriptional regulation of apolipoprotein AI gene expression by the nuclear receptor RORα J. Biol. Chem. 272 1997 22401 22404
18. E. Raspé, H. Duez, P. Gervois, C. Fiévet, J.-C. Fruchart, S. Besnard, J. Mariani, A. Tedgui, and B. Staels Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORα J. Biol. Chem. 276 2001 2865 2871
19. A. Genoux, H. Dehondt, A. Helleboid-Chapman, C. Duhem, D.W. Hum, G. Martin, L.A. Pennacchio, B. Staels, J. Fruchart-Najib, and J.-C. Fruchart Transcriptional regulation of apolipoprotein A5 gene expression by the nuclear receptor RORα Arterioscler. Thromb. Vasc. Biol. 25 2005 1186 1192
20. C. Chauvet, A. Vanhoutteghem, C. Duhem, G. Saint-Auret, B. Bois-Joyeux, P. Djian, B. Staels, and J.-L. Danan Control of gene expression by the retinoic acid-related orphan receptor alpha in HepG2 human hepatoma cells PLoS ONE 6 2011 e22545
21. D.A. Gold, P.M. Gent, and B.A. Hamilton RORα in genetic control of cerebellum development: 50 staggering years Brain Res. 1140 2007 19 25
22. A. Mamontova, S. Séguret-Macé, B. Esposito, C. Chaniale, M. Bouly, N. Delhaye-Bouchaud, G. Luc, B. Staels, N. Duverger, and J. Mariani Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORα Circulation 98 1998 2738 2743
23. I. Dussault, D. Fawcett, A. Matthyssen, J.-A. Bader, and V. Giguère Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer Mech. Dev. 70 1998 147 153
24. P. Lau, R. Fitzsimmons, M. Pearen, M. Watt, and G.E. Muscat Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle Diabetologia 54 2011 1169 1180
25. P. Lau, R.L. Fitzsimmons, S. Raichur, S.-C.M. Wang, A. Lechtken, and G.E. Muscat The orphan nuclear receptor, RORα, regulates gene expression that controls lipid metabolism J. Biol. Chem. 283 2008 18411 18421
26. M.G. Hayes, A. Pluzhnikov, K. Miyake, Y. Sun, M.C.Y. Ng, C.A. Roe, J.E. Below, R.I. Nicolae, A. Konkashbaev, and G.I. Bell Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies Diabetes 56 2007 3033 3044
27. Z. Su, Y. Li, J.C. James, A.H. Matsumoto, G.A. Helm, A.J. Lusis, and W. Shi Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice Hum. Mol. Genet. 15 2006 1650 1658
28. Z. Su, M. Leduc, R. Korstanje, and B. Paigen Untangling HDL quantitative trait loci on mouse chromosome 5 and identifying Scarb1 and Acads as the underlying genes J. Lipid Res. 51 2010 2706 2713
29. Y. Wang, N. Kumar, P. Nuhant, M.D. Cameron, M.A. Istrate, W.R. Roush, P.R. Griffin, and T.P. Burris Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and RORgamma ACS Chem. Biol. 5 2010 1029 1034
30. H.M. Docherty, C.W. Hay, L.A. Ferguson, J. Barrow, E. Durward, and K. Docherty Relative contribution of PDX-1, MafA and E47/β2 to the regulation of the human insulin promoter Biochem. J. 389 2005 813
31. M.L. Gishizky, and G.M. Grodsky Differential kinetics of rat insulin I and II processing in rat islets of Langerhans FEBS Lett. 223 1987 227 231
32. I. Wiesenberg, M. Missbach, J.P. Kahlen, M. Schrader, and C. Carlberg Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand Nucleic Acids Res. 23 1995 327 333
33. F. Zenri, H. Hiroi, M. Momoeda, R. Tsutsumi, Y. Hosokawa, M. Koizumi, H. Nakae, Y. Osuga, T. Yano, and Y. Taketani Expression of retinoic acid-related orphan receptor alpha and its responsive genes in human endometrium regulated by cholesterol sulfate J. Steroid Biochem. Mol. Biol. 128 2012 21 28
34. E.J. Kim, Y.G. Yoo, W.K. Yang, Y.S. Lim, T.Y. Na, I.K. Lee, and M.O. Lee Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling Arterioscler. Thromb. Vasc. Biol. 28 2008 1796 1802
35. M. Akashi, and T. Takumi The orphan nuclear receptor RORα regulates circadian transcription of the mammalian core-clock Bmal1 Nat. Struct. Mol. Biol. 12 2005 441 448
36. A.M. Jetten Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism Nucl. Recept. Signal. 7 2009
37. L.A. Solt, and T.P. Burris Action of RORs and their ligands in (patho) physiology Trends Endocrinol. Metab. 23 2012 619 627
38. G. Boden, J. Ruiz, J. Urbain, and X. Chen Evidence for a circadian rhythm of insulin secretion Am. J. Physiol. Endocrinol. Metab. 271 1996 E246 E252
39. N. Allaman-Pillet, R. Roduit, A. Oberson, S. Abdelli, J. Ruiz, J. Beckmann, D. Schorderet, and C. Bonny Circadian regulation of islet genes involved in insulin production and secretion Mol. Cell. Endocrinol. 226 2004 59 66
40. A.D. Laposky, J. Bass, A. Kohsaka, and F.W. Turek Sleep and circadian rhythms: key components in the regulation of energy metabolism FEBS Lett. 582 2008 142 151
41. E. Muhlbauer, I. Bazwinsky-Wutschke, S. Wolgast, K. Labucay, and E. Peschke Differential and day-time dependent expression of nuclear receptors RORalpha, RORbeta, RORgamma and RXRalpha in the rodent pancreas and islet Mol. Cell Endocrinol. 365 2013 129 138
42. S. Shibata Circadian rhythm and food Foods Food Ingredients J. Jpn. 213 2008 51
43. F.W. Turek, C. Joshu, A. Kohsaka, E. Lin, G. Ivanova, E. McDearmon, A. Laposky, S. Losee-Olson, A. Easton, and D.R. Jensen Obesity and metabolic syndrome in circadian Clock mutant mice Science 308 2005 1043
44. D.J. Kennaway, J.A. Owens, A. Voultsios, M.J. Boden, and T.J. Varcoe Metabolic homeostasis in mice with disrupted Clock gene expression in peripheral tissues Am. J. Physiol. Regul. Integr. 293 2007 R1528 R1537
45. B. Karlsson, A. Knutsson, and B. Lindahl Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27 485 people Occup. Environ. Med. 58 2001 747 752
46. M. Ha, and J. Park Shiftwork and metabolic risk factors of cardiovascular disease J. Occup. Health 47 2005 89 95
47. M.T. Hamilton, D.G. Hamilton, and T.W. Zderic Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease Diabetes 56 2007 2655 2667
48. A. Gupta, F. Greenway, G. Cornelissen, W. Pan, and F. Halberg Prediabetes is associated with abnormal circadian blood pressure variability J. Hum. Hypertens. 22 2008 627 633
49. F.A. Scheer, M.F. Hilton, C.S. Mantzoros, and S.A. Shea Adverse metabolic and cardiovascular consequences of circadian misalignment Proc. Natl. Acad. Sci. U.S.A. 106 2009 4453 4458
50. E. Maury, K.M. Ramsey, and J. Bass Circadian rhythms and metabolic syndrome from experimental genetics to human disease Circ. Res. 106 2010 447 462