Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans

PLoS Genetics

Volumn 12, Issue 9, 2016, Pages

  Cattie, Douglas J ^a   Richardson, Claire E ^a,c   Reddy, Kirthi C ^a,d   Ness Cohn, Elan M ^a   Droste, Rita ^a,b   Thompson, Mary K ^a   Gilbert, Wendy V ^a   Kim, Dennis H ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; INITIATION FACTOR 2ALPHA; INITIATION FACTOR 2ALPHA KINASE PEK 1; INITIATION FACTOR 3; INITIATION FACTOR EIF3K; INITIATION FACTOR EIF3L; TRANSCRIPTION FACTOR DAF 16; TUNICAMYCIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; CAENORHABDITIS ELEGANS PROTEIN; MICROTUBULE ASSOCIATED PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; ATF 6 GENE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DAF 16 GENE; EIF3K GENE; EIF3L GENE; ENDOPLASMIC RETICULUM STRESS; ESCHERICHIA COLI; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; IRE 1 GENE; LARVAL STAGE; LETHALITY; LIFE EXTENSION; LOSS OF FUNCTION MUTATION; MUTANT; NONHUMAN; PARASITE VIABILITY; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; UNFOLDED PROTEIN RESPONSE; WILD TYPE; XBP 1 GENE; ADAPTATION; AGING; ANIMAL; GENETICS; LONGEVITY; METABOLISM; MUTATION; PHYSIOLOGICAL STRESS; TRANSGENIC ANIMAL;

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-3; LONGEVITY; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; STRESS, PHYSIOLOGICAL;

EID: 84990196976     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006326     Document Type: Article

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