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Volumn 7, Issue 5, 2011, Pages

A decline in p38 MAPK signaling underlies immunosenescence in caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR DAF 16; CAENORHABDITIS ELEGANS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PMK 1 PROTEIN, C ELEGANS; PMK-1 PROTEIN, C ELEGANS;

EID: 79957992660     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002082     Document Type: Article
Times cited : (98)

References (40)
  • 1
    • 67649410701 scopus 로고    scopus 로고
    • An evolutionary perspective on the mechanisms of immunosenescence
    • Shanley DP, Aw D, Manley NR, Palmer DB, (2009) An evolutionary perspective on the mechanisms of immunosenescence. Trends Immunol 30: 374-381.
    • (2009) Trends Immunol , vol.30 , pp. 374-381
    • Shanley, D.P.1    Aw, D.2    Manley, N.R.3    Palmer, D.B.4
  • 2
    • 67649397909 scopus 로고    scopus 로고
    • Human innate immunosenescence: causes and consequences for immunity in old age
    • Panda A, Arjona A, Sapey E, Bai F, Fikrig E, et al. (2009) Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol 30: 325-333.
    • (2009) Trends Immunol , vol.30 , pp. 325-333
    • Panda, A.1    Arjona, A.2    Sapey, E.3    Bai, F.4    Fikrig, E.5
  • 3
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, et al. (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128: 92-105.
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5
  • 4
    • 47749112908 scopus 로고    scopus 로고
    • Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly
    • Kong KF, Delroux K, Wang X, Qian F, Arjona A, et al. (2008) Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol 82: 7613-7623.
    • (2008) J Virol , vol.82 , pp. 7613-7623
    • Kong, K.F.1    Delroux, K.2    Wang, X.3    Qian, F.4    Arjona, A.5
  • 5
    • 22144485227 scopus 로고    scopus 로고
    • Aging of the innate immune response in Drosophila melanogaster
    • Zerofsky M, Harel E, Silverman N, Tatar M, (2005) Aging of the innate immune response in Drosophila melanogaster. Aging Cell 4: 103-108.
    • (2005) Aging Cell , vol.4 , pp. 103-108
    • Zerofsky, M.1    Harel, E.2    Silverman, N.3    Tatar, M.4
  • 6
    • 40549086285 scopus 로고    scopus 로고
    • Functional analysis of the Drosophila immune response during aging
    • Ramsden S, Cheung YY, Seroude L, (2008) Functional analysis of the Drosophila immune response during aging. Aging Cell 7: 225-236.
    • (2008) Aging Cell , vol.7 , pp. 225-236
    • Ramsden, S.1    Cheung, Y.Y.2    Seroude, L.3
  • 7
    • 0036021375 scopus 로고    scopus 로고
    • Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
    • Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, et al. (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
    • (2002) Genetics , vol.161 , pp. 1101-1112
    • Garigan, D.1    Hsu, A.L.2    Fraser, A.G.3    Kamath, R.S.4    Ahringer, J.5
  • 8
    • 0037167855 scopus 로고    scopus 로고
    • Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    • Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, et al. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 808-814.
    • (2002) Nature , vol.419 , pp. 808-814
    • Herndon, L.A.1    Schmeissner, P.J.2    Dudaronek, J.M.3    Brown, P.A.4    Listner, K.M.5
  • 9
    • 0034036321 scopus 로고    scopus 로고
    • Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans
    • Gems D, Riddle DL, (2000) Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154: 1597-1610.
    • (2000) Genetics , vol.154 , pp. 1597-1610
    • Gems, D.1    Riddle, D.L.2
  • 10
    • 0037178731 scopus 로고    scopus 로고
    • A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    • Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297: 623-626.
    • (2002) Science , vol.297 , pp. 623-626
    • Kim, D.H.1    Feinbaum, R.2    Alloing, G.3    Emerson, F.E.4    Garsin, D.A.5
  • 11
    • 41549104500 scopus 로고    scopus 로고
    • Distinct innate immune responses to infection and wounding in the C. elegans epidermis
    • Pujol N, Cypowyj S, Ziegler K, Millet A, Astrain A, et al. (2008) Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol 18: 481-489.
    • (2008) Curr Biol , vol.18 , pp. 481-489
    • Pujol, N.1    Cypowyj, S.2    Ziegler, K.3    Millet, A.4    Astrain, A.5
  • 12
    • 77952376722 scopus 로고    scopus 로고
    • Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
    • doi:10.1371/journal.pgen.1000892
    • Shivers RP, Pagano DJ, Kooistra T, Richardson CE, Reddy KC, et al. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet 6: e1000892 doi:10.1371/journal.pgen.1000892.
    • (2010) PLoS Genet , vol.6
    • Shivers, R.P.1    Pagano, D.J.2    Kooistra, T.3    Richardson, C.E.4    Reddy, K.C.5
  • 13
    • 33751382748 scopus 로고    scopus 로고
    • P38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    • doi:10.1371/journal.pgen.0020183
    • Troemel ER, Chu SW, Reinke V, Lee SS, Ausubel FM, et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet 2: e183 doi:10.1371/journal.pgen.0020183.
    • (2006) PLoS Genet , vol.2
    • Troemel, E.R.1    Chu, S.W.2    Reinke, V.3    Lee, S.S.4    Ausubel, F.M.5
  • 14
    • 45849133385 scopus 로고    scopus 로고
    • Transcriptional responses to pathogens in Caenorhabditis elegans
    • Shivers RP, Youngman MJ, Kim DH, (2008) Transcriptional responses to pathogens in Caenorhabditis elegans. Curr Opin Microbiol 11: 251-256.
    • (2008) Curr Opin Microbiol , vol.11 , pp. 251-256
    • Shivers, R.P.1    Youngman, M.J.2    Kim, D.H.3
  • 15
    • 0033582314 scopus 로고    scopus 로고
    • Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis
    • Tan MW, Mahajan-Miklos S, Ausubel FM, (1999) Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis. Proc Natl Acad Sci U S A 96: 715-720.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 715-720
    • Tan, M.W.1    Mahajan-Miklos, S.2    Ausubel, F.M.3
  • 16
    • 0037731431 scopus 로고    scopus 로고
    • Caenorhabditis elegans: an emerging genetic model for the study of innate immunity
    • Kurz CL, Ewbank JJ, (2003) Caenorhabditis elegans: an emerging genetic model for the study of innate immunity. Nat Rev Genet 4: 380-390.
    • (2003) Nat Rev Genet , vol.4 , pp. 380-390
    • Kurz, C.L.1    Ewbank, J.J.2
  • 17
    • 2342646043 scopus 로고    scopus 로고
    • Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria
    • Laws TR, Harding SV, Smith MP, Atkins TP, Titball RW, (2004) Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS Microbiol Lett 234: 281-287.
    • (2004) FEMS Microbiol Lett , vol.234 , pp. 281-287
    • Laws, T.R.1    Harding, S.V.2    Smith, M.P.3    Atkins, T.P.4    Titball, R.W.5
  • 18
    • 0037125942 scopus 로고    scopus 로고
    • Transcriptional profile of aging in C. elegans
    • Lund J, Tedesco P, Duke K, Wang J, Kim SK, et al. (2002) Transcriptional profile of aging in C. elegans. Curr Biol 12: 1566-1573.
    • (2002) Curr Biol , vol.12 , pp. 1566-1573
    • Lund, J.1    Tedesco, P.2    Duke, K.3    Wang, J.4    Kim, S.K.5
  • 19
    • 47549100826 scopus 로고    scopus 로고
    • An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans
    • Budovskaya YV, Wu K, Southworth LK, Jiang M, Tedesco P, et al. (2008) An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell 134: 291-303.
    • (2008) Cell , vol.134 , pp. 291-303
    • Budovskaya, Y.V.1    Wu, K.2    Southworth, L.K.3    Jiang, M.4    Tedesco, P.5
  • 20
    • 41549093748 scopus 로고    scopus 로고
    • Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection
    • Wong D, Bazopoulou D, Pujol N, Tavernarakis N, Ewbank JJ, (2007) Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection. Genome Biol 8: R194.
    • (2007) Genome Biol , vol.8
    • Wong, D.1    Bazopoulou, D.2    Pujol, N.3    Tavernarakis, N.4    Ewbank, J.J.5
  • 21
    • 35448934999 scopus 로고    scopus 로고
    • The genetics of pathogen avoidance in Caenorhabditis elegans
    • Schulenburg H, Ewbank JJ, (2007) The genetics of pathogen avoidance in Caenorhabditis elegans. Mol Microbiol 66: 563-570.
    • (2007) Mol Microbiol , vol.66 , pp. 563-570
    • Schulenburg, H.1    Ewbank, J.J.2
  • 22
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424: 277-283.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 23
    • 7244238167 scopus 로고    scopus 로고
    • Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance
    • McElwee JJ, Schuster E, Blanc E, Thomas JH, Gems D, (2004) Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem 279: 44533-44543.
    • (2004) J Biol Chem , vol.279 , pp. 44533-44543
    • McElwee, J.J.1    Schuster, E.2    Blanc, E.3    Thomas, J.H.4    Gems, D.5
  • 24
    • 33846818720 scopus 로고    scopus 로고
    • The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine
    • McGhee JD, Sleumer MC, Bilenky M, Wong K, McKay SJ, et al. (2007) The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine. Dev Biol 302: 627-645.
    • (2007) Dev Biol , vol.302 , pp. 627-645
    • McGhee, J.D.1    Sleumer, M.C.2    Bilenky, M.3    Wong, K.4    McKay, S.J.5
  • 25
    • 32244446124 scopus 로고    scopus 로고
    • Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans
    • Pauli F, Liu Y, Kim YA, Chen PJ, Kim SK, (2006) Chromosomal clustering and GATA transcriptional regulation of intestine-expressed genes in C. elegans. Development 133: 287-295.
    • (2006) Development , vol.133 , pp. 287-295
    • Pauli, F.1    Liu, Y.2    Kim, Y.A.3    Chen, P.J.4    Kim, S.K.5
  • 26
    • 3342899839 scopus 로고    scopus 로고
    • Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase
    • Kim DH, Liberati NT, Mizuno T, Inoue H, Hisamoto N, et al. (2004) Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A 101: 10990-10994.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10990-10994
    • Kim, D.H.1    Liberati, N.T.2    Mizuno, T.3    Inoue, H.4    Hisamoto, N.5
  • 28
    • 0345447590 scopus 로고    scopus 로고
    • Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
    • Libina N, Berman JR, Kenyon C, (2003) Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115: 489-502.
    • (2003) Cell , vol.115 , pp. 489-502
    • Libina, N.1    Berman, J.R.2    Kenyon, C.3
  • 29
    • 0032538315 scopus 로고    scopus 로고
    • Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span
    • Apfeld J, Kenyon C, (1998) Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell 95: 199-210.
    • (1998) Cell , vol.95 , pp. 199-210
    • Apfeld, J.1    Kenyon, C.2
  • 30
    • 0034613164 scopus 로고    scopus 로고
    • Regulation of C. elegans life-span by insulinlike signaling in the nervous system
    • Wolkow CA, Kimura KD, Lee MS, Ruvkun G, (2000) Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290: 147-150.
    • (2000) Science , vol.290 , pp. 147-150
    • Wolkow, C.A.1    Kimura, K.D.2    Lee, M.S.3    Ruvkun, G.4
  • 31
    • 37649022616 scopus 로고    scopus 로고
    • Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans
    • Murphy CT, Lee SJ, Kenyon C, (2007) Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A 104: 19046-19050.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19046-19050
    • Murphy, C.T.1    Lee, S.J.2    Kenyon, C.3
  • 32
    • 0034596988 scopus 로고    scopus 로고
    • A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses
    • Koga M, Zwaal R, Guan KL, Avery L, Ohshima Y, (2000) A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. Embo J 19: 5148-5156.
    • (2000) Embo J , vol.19 , pp. 5148-5156
    • Koga, M.1    Zwaal, R.2    Guan, K.L.3    Avery, L.4    Ohshima, Y.5
  • 33
    • 33750047495 scopus 로고    scopus 로고
    • Management of sepsis
    • Russell JA, (2006) Management of sepsis. N Engl J Med 355: 1699-1713.
    • (2006) N Engl J Med , vol.355 , pp. 1699-1713
    • Russell, J.A.1
  • 34
    • 77649135472 scopus 로고    scopus 로고
    • An essential role for XBP-1 in host protection against immune activation in C. elegans
    • Richardson CE, Kooistra T, Kim DH, (2010) An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature 463: 1092-1095.
    • (2010) Nature , vol.463 , pp. 1092-1095
    • Richardson, C.E.1    Kooistra, T.2    Kim, D.H.3
  • 35
    • 39849104918 scopus 로고    scopus 로고
    • Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans
    • Hoogewijs D, Houthoofd K, Matthijssens F, Vandesompele J, Vanfleteren JR, (2008) Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans. BMC Mol Biol 9: 9.
    • (2008) BMC Mol Biol , vol.9 , pp. 9
    • Hoogewijs, D.1    Houthoofd, K.2    Matthijssens, F.3    Vandesompele, J.4    Vanfleteren, J.R.5
  • 36
    • 48149113439 scopus 로고    scopus 로고
    • Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans
    • Pocock R, Hobert O, (2008) Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans. Nat Neurosci 11: 894-900.
    • (2008) Nat Neurosci , vol.11 , pp. 894-900
    • Pocock, R.1    Hobert, O.2
  • 37
    • 2542610720 scopus 로고    scopus 로고
    • Preprocessing of oligonucleotide array data
    • author reply 658
    • Wu Z, Irizarry RA, (2004) Preprocessing of oligonucleotide array data. Nat Biotechnol 22: 656-658; author reply, 658.
    • (2004) Nat Biotechnol , vol.22 , pp. 656-658
    • Wu, Z.1    Irizarry, R.A.2
  • 38
    • 21444445084 scopus 로고    scopus 로고
    • BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments
    • Al-Shahrour F, Minguez P, Vaquerizas JM, Conde L, Dopazo J, (2005) BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments. Nucleic Acids Res 33: W460-464.
    • (2005) Nucleic Acids Res , vol.33 , pp. 460-464
    • Al-Shahrour, F.1    Minguez, P.2    Vaquerizas, J.M.3    Conde, L.4    Dopazo, J.5
  • 39
    • 0037448540 scopus 로고    scopus 로고
    • Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    • Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231-237.
    • (2003) Nature , vol.421 , pp. 231-237
    • Kamath, R.S.1    Fraser, A.G.2    Dong, Y.3    Poulin, G.4    Durbin, R.5
  • 40
    • 0035941485 scopus 로고    scopus 로고
    • Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
    • Timmons L, Court DL, Fire A, (2001) Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 263: 103-112.
    • (2001) Gene , vol.263 , pp. 103-112
    • Timmons, L.1    Court, D.L.2    Fire, A.3


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