Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health

Obesity

Volumn 24, Issue 6, 2016, Pages 1380-1388

  Menni, Cristina ^a   Migaud, Marie ^b   Glastonbury, Craig A ^a   Beaumont, Michelle ^a   Nikolaou, Aikaterini ^a   Small, Kerrin S ^a   Brosnan, Mary Julia ^c   Mohney, Robert P ^d   Spector, Tim D ^a   Valdes, Ana M ^a,e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c PFIZER INC   (United States)

^d METABOLON INC   (United States)

^e NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; BRANCHED CHAIN AMINO ACID; GLUCOSE; LACTIC ACID; PALMITIC ACID; PEPTIDE;

ADULT; ARTICLE; BLOOD PRESSURE; CITRIC ACID CYCLE; FAT MASS; FEMALE; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INTRAPERITONEAL FAT; MAJOR CLINICAL STUDY; METABOLISM; METABOLITE; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS;

EID: 84990192148     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21488     Document Type: Article

References (38)

1. Finelli C, Sommella L, Gioia S, La Sala N, Tarantino G. Should visceral fat be reduced to increase longevity? Ageing Res Rev 2013;12:996-1004.
2. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-2556.
3. Floegel A, Stefan N, Yu Z, et al. Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 2013;62:639-648.
4. Gall WE, Beebe K, Lawton KA, et al. alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 2010;5:e10883.
5. Menni C, Fauman E, Erte I, et al. Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes 2013;62:4270-4276.
6. Suhre K, Meisinger C, Doring A, et al. Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One 2010;5:e13953.
7. Wang TJ, Larson MG, Vasan RS, et al. Metabolite profiles and the risk of developing diabetes. Nat Med 2011;17:448-453.
8. Wurtz P, Tiainen M, Makinen VP, et al. Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care 2012;35:1749-1756.
9. Menni C, Graham D, Kastenmuller G, et al. Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension 2015;66:422–429.
10. Ebbert JO, Jensen MD. Fat depots, free fatty acids, and dyslipidemia. Nutrients 2013;5:498-508.
11. Klein S. The case of visceral fat: argument for the defense. J Clin Invest 2004;113:1530-1532.
12. Su X, Abumrad NA. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metabol 2009;20:72-77.
13. Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One 2010;5:e15234.
14. Moayyeri A, Hammond CJ, Valdes AM, Spector TD. Cohort profile: TwinsUK and healthy ageing twin study. Int J Epidemiol 2013;42:76-85.
15. Kaul S, Rothney MP, Peters DM, et al. Dual-energy X-ray absorptiometry for quantification of visceral fat. Obesity (Silver Spring) 2012;20:1313-1318.
16. Falchi M, Wilson SG, Paximadas D, Swaminathan R, Spector TD. Quantitative linkage analysis for pancreatic B-cell function and insulin resistance in a large twin cohort. Diabetes 2008;57:1120-1124.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
18. Menni C, Kastenmuller G, Petersen AK, et al. Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol 2013;42:1111-1119.
19. Grundberg E, Small KS, Hedman AK, et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet 2012;44:1084-1089.
20. Przybyla-Zawislak B, Gadde DM, Ducharme K, McCammon MT. Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes. Genetics 1999;152:153-166.
21. Lee JJ, Lambert JE, Hovhannisyan Y, et al. Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis. Am J Clin Nutr 2015;101:34-43.
22. Vaneckova I, Maletinska L, Behuliak M, Nagelova V, Zicha J, Kunes J. Obesity-related hypertension: possible pathophysiological mechanisms. J Endocrinol 2014;223:R63-R78.
23. Brosnan JT, Brosnan ME. Branched-chain amino acids: enzyme and substrate regulation. J Nutr 2006;136:207S-211S.
24. Sears DD, Hsiao G, Hsiao A, et al. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci USA 2009;106:18745-18750.
25. Badoud F, Lam KP, DiBattista A, et al. Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese. J Proteome Res 2014;13:3455-3466.
26. Gaster M, Nehlin JO, Minet AD. Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: marker or maker of the diabetic phenotype? Arch Physiol Biochem 2012;118:156-189.
27. Lovejoy J, Newby FD, Gebhart SS, DiGirolamo M. Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Metabolism 1992;41:22-27.
28. Tuder RM, Davis LA, Graham BB. Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med 2012;185:260-266.
29. Finkelstein JL, Pressman EK, Cooper EM, Kent TR, Bar HY, O'Brien KO, Vitamin D. Status affects serum metabolomic profiles in pregnant adolescents. Reprod Sci 2014;22(6):422–429.
30. Dousset B, Straczek J, Maachi F, et al. Purification from human plasma of a hexapeptide that potentiates the sulfation and mitogenic activities of insulin-like growth factors. Biochem Biophys Res Commun 1998;247:587-591.
31. Altmaier E, Fobo G, Heier M, et al. Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol 2014;29:325-336.
32. Perng W, Gillman MW, Fleisch AF, et al. Metabolomic profiles and childhood obesity. Obesity (Silver Spring) 2014;22:2570-2578.
33. Kien CL, Bunn JY, Ugrasbul F. Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. Am J Clin Nutr 2005;82:320-326.
34. Lithander FE, Herlihy LK, Walsh DM, Burke E, Crowley V, Mahmud A. Postprandial effect of dietary fat quantity and quality on arterial stiffness and wave reflection: a randomised controlled trial. Nutr J 2013;12:93
35. Menni C, Mangino M, Cecelja M, et al. Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens 2015;33:791-796.
36. Parrinello CM, Selvin E. Beyond HbA1c and glucose: the role of nontraditional glycemic markers in diabetes diagnosis, prognosis, and management. Curr Diabetes Rep 2014;14:548
37. Newgard CB, An J, Bain JR, et al. A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9:311-326.
38. Steven S, Taylor R. Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration Type 2 diabetes. Diabet Med 2015;32(9):1149–1155.