Fat depots, free fatty acids, and dyslipidemia

Nutrients

Volumn 5, Issue 2, 2013, Pages 495-508

  Ebbert, Jon O ^a   Jensen, Michael D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Dyslipidemia; Fat depots; Free fatty acid

Indexed keywords

CHYLOMICRON; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

BODY FAT DISTRIBUTION; CARDIOVASCULAR RISK; CONCENTRATION (PARAMETERS); DYSLIPIDEMIA; FATTY ACID ANALYSIS; FATTY ACID METABOLISM; GLYCOGEN SYNTHESIS; HUMAN; HYPERINSULINEMIA; INSULIN CLEARANCE; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPID STORAGE; LIPOLYSIS; LIPOPROTEIN METABOLISM; LIVER METABOLISM; OBESITY; REVIEW; RISK ASSESSMENT; ABDOMINAL OBESITY; ADIPOCYTE; BLOOD; CARDIOVASCULAR DISEASE; FEMALE; HYPERTRIGLYCERIDEMIA; LIVER; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR;

ADIPOCYTES; BODY FAT DISTRIBUTION; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; DYSLIPIDEMIAS; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPOLYSIS; LIVER; MALE; OBESITY; OBESITY, ABDOMINAL; RISK FACTORS;

EID: 84884407233     PISSN: 20726643     EISSN: None     Source Type: Journal    
DOI: 10.3390/nu5020498     Document Type: Review

References (73)

1. Lakka, T.A.; Lakka, H.M.; Salonen, R.; Kaplan, G.A.; Salonen, J.T. Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men. Atherosclerosis 2001, 154, 497-504.
2. Lakka, H.M.; Lakka, T.A.; Tuomilehto, J.; Salonen, J.T. Abdominal obesity is associated with increased risk of acute coronary events in men. Eur. Heart J. 2002, 23, 706-713.
3. Despres, J.P.; Moorjani, S.; Lupien, P.J.; Tremblay, A.; Nadeau, A.; Bouchard, C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis 1990, 10, 497-511.
4. Jensen, M.D. Role of body fat distribution and the metabolic complications of obesity. J. Clin. Endocrinol. Metab. 2008, 93, S57-S63.
5. Bjorntorp, P. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990, 10, 493-496.
6. Kissebah, A.H.; Peiris, A.N. Biology of regional body fat distribution: Relationship to non-insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 1989, 5, 83-109.
7. Fontana, L.; Eagon, J.C.; Trujillo, M.E.; Scherer, P.E.; Klein, S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56, 1010-1013.
8. Wisneski, J.A.; Gertz, E.W.; Neese, R.A.; Mayr, M. Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans. J. Clinical Investig. 1987, 79, 359-366.
9. Havel, R.J.; Kane, J.P.; Balasse, E.O.; Segel, N.; Basso, L.V. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J. Clin. Invest. 1970, 49, 2017-2035.
10. Kelley, D.E.; Goodpaster, B.; Wing, R.R.; Simoneau, J.A. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 1999, 277, E1130-E1141.
11. Byrne, C.D.; Wareham, N.J.; Brown, D.C.; Clark, P.M.; Cox, L.J.; Day, N.E.; Palmer, C.R.; Wang, T.W.; Williams, D.R.; Hales, C.N. Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: Relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids. Diabetologia 1994, 37, 889-896.
12. Lewis, G.F.; O'Meara, N.M.; Soltys, P.A.; Blackman, J.D.; Iverius, P.H.; Pugh, W.L.; Getz, G.S.; Polonsky, K.S. Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities. J. Clin. Endocrinol. Metab. 1991, 72, 934-944.
13. McKeigue, P.M.; Laws, A.; Chen, Y.D.; Marmot, M.G.; Reaven, G.M. Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Possible explanation for sex differences in lipoprotein pattern. Arterioscler. Thromb. 1993, 13, 1187-1192.
14. Yki-Jarvinen, H.; Taskinen, M.R. Interrelationships among insulin's antilipolytic and glucoregulatory effects and plasma triglycerides in nondiabetic and diabetic patients with endogenous hypertriglyceridemia. Diabetes 1988, 37, 1271-1278.
15. Poirier, P.; Giles, T.D.; Bray, G.A.; Hong, Y.; Stern, J.S.; Pi-Sunyer, F.X.; Eckel, R.H. Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006, 113, 898-918.
16. Goossens, G.H. The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol. Behav. 2008, 94, 206-218.
17. Frayn, K.N. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002, 45, 1201-1210.
18. Tchoukalova, Y.D.; Koutsari, C.; Votruba, S.B.; Tchkonia, T.; Giorgadze, N.; Thomou, T.; Kirkland, J.L.; Jensen, M.D. Sex- and depot-dependent differences in adipogenesis in normal-weight humans. Obesity (Silver Spring) 2010, 18, 1875-1880.
19. Kelley, D.E.; Thaete, F.L.; Troost, F.; Huwe, T.; Goodpaster, B.H. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 2000, 278, E941-E948.
20. Jensen, M.D.; Sarr, M.G.; Dumesic, D.A.; Southorn, P.A.; Levine, J.A. Regional uptake of meal fatty acids in humans. Am. J. Physiol. Endocrinol. Metab. 2003, 285, E1282-E1288.
21. Rosito, G.A.; Massaro, J.M.; Hoffmann, U.; Ruberg, F.L.; Mahabadi, A.A.; Vasan, R.S.; O'Donnell, C.J.; Fox, C.S. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. Circulation 2008, 117, 605-613.
22. Birkenhager, J.C.; Tjabbes, T. Turnover rate of plasma FFA and rate of esterification of plasma FFA to plasma triglycerides in obese humans before and after weight reduction. Metabolism 1969, 18, 18-32.
23. Campbell, P.J.; Carlson, M.G.; Nurjhan, N. Fat metabolism in human obesity. Am. J. Physiol. 1994, 266, E600-E605.
24. Horowitz, J.F.; Coppack, S.W.; Paramore, D.; Cryer, P.E.; Zhao, G.; Klein, S. Effect of short-term fasting on lipid kinetics in lean and obese women. Am. J. Physiol. 1999, 276, E278-E284.
25. McQuaid, S.E.; Hodson, L.; Neville, M.J.; Dennis, A.L.; Cheeseman, J.; Humphreys, S.M.; Ruge, T.; Gilbert, M.; Fielding, B.A.; Frayn, K.N.; Karpe, F. Downregulation of adipose tissue fatty acid trafficking in obesity: A driver for ectopic fat deposition? Diabetes 2011, 60, 47-55.
26. Kissebah, A.H.; Krakower, G.R. Regional adiposity and morbidity. Physiol. Rev. 1994, 74, 761-811.
27. Fox, C.S.; Massaro, J.M.; Hoffmann, U.; Pou, K.M.; Maurovich-Horvat, P.; Liu, C.Y.; Vasan, R.S.; Murabito, J.M.; Meigs, J.B.; Cupples, L.A. et al. Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study. Circulation 2007, 116, 39-48.
28. Manolopoulos, K.N.; Karpe, F.; Frayn, K.N. Gluteofemoral body fat as a determinant of metabolic health. Int. J. Obes. (Lond.) 2010, 34, 949-959.
29. Snijder, M.B.; Zimmet, P.Z.; Visser, M.; Dekker, J.M.; Seidell, J.C.; Shaw, J.E. Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: The AusDiab Study. Int. J. Obes. Relat. Metab. Disord. 2004, 28, 402-409.
30. Nielsen, S.; Guo, Z.; Albu, J.B.; Klein, S.; O'Brien, P.C.; Jensen, M.D. Energy expenditure, sex, and endogenous fuel availability in humans. J. Clin. Invest. 2003, 111, 981-988.
31. Saloranta, C.; Franssila-Kallunki, A.; Ekstrand, A.; Taskinen, M.R.; Groop, L. Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991, 34, 409-415.
32. Boden, G.; Chen, X. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J. Clin. Invest. 1995, 96, 1261-1268.
33. Roden, M.; Price, T.B.; Perseghin, G.; Petersen, K.F.; Rothman, D.L.; Cline, G.W.; Shulman, G.I. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 1996, 97, 2859-2865.
34. Rebrin, K.; Steil, G.M.; Getty, L.; Bergman, R.N. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 1995, 44, 1038-1045.
35. Boden, G.; Jadali, F.; White, J.; Liang, Y.; Mozzoli, M.; Chen, X.; Coleman, E.; Smith, C. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J. Clin. Invest. 1991, 88, 960-966.
36. Hennes, M.M.; Shrago, E.; Kissebah, A.H. Receptor and postreceptor effects of free fatty acids (FFA) on hepatocyte insulin dynamics. Int. J. Obes. 1990, 14, 831-841.
37. Kissebah, A.H.; Alfarsi, S.; Adams, P.W.; Wynn, V. Role of insulin resistance in adipose tissue and liver in the pathogenesis of endogenous hypertriglyceridaemia in man. Diabetologia 1976, 12, 563-571.
38. Jensen, M.D.; Haymond, M.W.; Rizza, R.A.; Cryer, P.E.; Miles, J.M. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 1989, 83, 1168-1173.
39. Guo, Z.; Hensrud, D.D.; Johnson, C.M.; Jensen, M.D. Regional postprandial fatty acid metabolism in different obesity phenotypes. Diabetes 1999, 48, 1586-1592.
40. Roust, L.R.; Jensen, M.D. Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 1993, 42, 1567-1573.
41. Basso, L.V.; Havel, R.J. Hepatic metabolism of free fatty acids in normal and diabetic dogs. J. Clin. Invest. 1970, 49, 537-547.
42. Jensen, M.D.; Cardin, S.; Edgerton, D.; Cherrington, A. Splanchnic free fatty acid kinetics. Am. J. Physiol. Endocrinol. Metab. 2003, 284, E1140-E1148.
43. Nielsen, S.; Guo, Z.; Johnson, C.M.; Hensrud, D.D.; Jensen, M.D. Splanchnic lipolysis in human obesity. J. Clin. Invest. 2004, 113, 1582-1588.
44. Kissebah, A.H.; Adams, P.W.; Wynn, V. Plasma free fatty acid and triglyceride transport kinetics in man. Clin. Sci. Mol. Med. 1974, 47, 259-278.
45. McBride, P. Triglycerides and risk for coronary artery disease. Curr. Atheroscler. Rep. 2008, 10, 386-390.
46. Abdel-Maksoud, M.F.; Hokanson, J.E. The complex role of triglycerides in cardiovascular disease. Semin. Vasc. Med. 2002, 2, 325-333.
47. Veilleux, A.; Caron-Jobin, M.; Noel, S.; Laberge, P.Y.; Tchernof, A. Visceral adipocyte hypertrophy is associated with dyslipidemia independent of body composition and fat distribution in women. Diabetes 2011, 60, 1504-1511.
48. Lemieux, I.; Poirier, P.; Bergeron, J.; Almeras, N.; Lamarche, B.; Cantin, B.; Dagenais, G.R.; Despres, J.P. Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? Can. J. Cardiol. 2007, 23, 23B-31B.
49. Choi, S.H.; Ginsberg, H.N. Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. Trends Endocrinol. Metab. 2011, 22, 353-363.
50. Rashid, S.; Uffelman, K.D.; Lewis, G.F. The mechanism of HDL lowering in hypertriglyceridemic, insulin-resistant states. J. Diabetes Complications 2002, 16, 24-28.
51. Despres, J.P.; Moorjani, S.; Tremblay, A.; Ferland, M.; Lupien, P.J.; Nadeau, A.; Bouchard, C. Relation of high plasma triglyceride levels associated with obesity and regional adipose tissue distribution to plasma lipoprotein-lipid composition in premenopausal women. Clin. Invest. Med. 1989, 12, 374-380.
52. Eisenberg, S. Lipoprotein abnormalities in hypertriglyceridemia: Significance in atherosclerosis. Am. Heart J. 1987, 113, 555-561.
53. Meek, S.E.; Nair, K.S.; Jensen, M.D. Insulin regulation of regional free fatty acid metabolism. Diabetes 1999, 48, 10-14.
54. Fabbrini, E.; Mohammed, B.S.; Magkos, F.; Korenblat, K.M.; Patterson, B.W.; Klein, S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 2008, 134, 424-431.
55. Basu, A.; Basu, R.; Shah, P.; Vella, A.; Rizza, R.A.; Jensen, M.D. Systemic and regional free fatty acid metabolism in type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 2001, 280, E1000-E1006.
56. Cohn, J.S.; Patterson, B.W.; Uffelman, K.D.; Davignon, J.; Steiner, G. Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J. Clin. Endocrinol. Metab. 2004, 89, 3949-3955.
57. Krause, B.R.; Hartman, A.D. Adipose tissue and cholesterol metabolism. J. Lipid Res. 1984, 25, 97-110.
58. Wang, H.; Peng, D.Q. New insights into the mechanism of low high-density lipoprotein cholesterol in obesity. Lipids Health Dis. 2011, 10, 176.
59. Gordon, T.; Castelli, W.P.; Hjortland, M.C.; Kannel, W.B.; Dawber, T.R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 1977, 62, 707-714.
60. Castelli, W.P.; Garrison, R.J.; Wilson, P.W.; Abbott, R.D.; Kalousdian, S.; Kannel, W.B. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA 1986, 256, 2835-2838.
61. Gotto, A.M., Jr.; Whitney, E.; Stein, E.A.; Shapiro, D.R.; Clearfield, M.; Weis, S.; Jou, J.Y.; Langendorfer, A.; Beere, P.A.; Watson, D.J. et al. Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Circulation 2000, 101, 477-484.
62. Gordon, D.J.; Probstfield, J.L.; Garrison, R.J.; Neaton, J.D.; Castelli, W.P.; Knoke, J.D.; Jacobs, D.R., Jr.; Bangdiwala, S.; Tyroler, H.A. High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. Circulation 1989, 79, 8-15.
63. Shah, P.K.; Kaul, S.; Nilsson, J.; Cercek, B. Exploiting the vascular protective effects of high-density lipoprotein and its apolipoproteins: An idea whose time for testing is coming, part I. Circulation 2001, 104, 2376-2383.
64. Kekki, M. Lipoprotein-lipase action determining plasma high density lipoprotein cholesterol level in adult normolipaemics. Atherosclerosis 1980, 37, 143-150.
65. Eisenberg, S. Lipoproteins and lipoprotein metabolism. A dynamic evaluation of the plasma fat transport system. Klin. Wochenschr. 1983, 61, 119-132.
66. Eisenberg, S. High density lipoprotein metabolism. J. Lipid Res. 1984, 25, 1017-1058.
67. Nikkila, E.A.; Taskinen, M.R.; Sane, T. Plasma high-density lipoprotein concentration and subfraction distribution in relation to triglyceride metabolism. Am. Heart J. 1987, 113, 543-548.
68. Tikkanen, M.J.; Nikkila, E.A. Regulation of hepatic lipase and serum lipoproteins by sex steroids. Am. Heart J. 1987, 113, 562-567.
69. Pouliot, M.C.; Despres, J.P.; Moorjani, S.; Lupien, P.J.; Tremblay, A.; Nadeau, A.; Bouchard, C. Regional variation in adipose tissue lipoprotein lipase activity: Association with plasma high density lipoprotein levels. Eur. J. Clin. Invest. 1991, 21, 398-405.
70. Despres, J.P.; Ferland, M.; Moorjani, S.; Nadeau, A.; Tremblay, A.; Lupien, P.J.; Theriault, G.; Bouchard, C. Role of hepatic-triglyceride lipase activity in the association between intra-abdominal fat and plasma HDL cholesterol in obese women. Arteriosclerosis 1989, 9, 485-492.
71. Carr, M.C.; Hokanson, J.E.; Zambon, A.; Deeb, S.S.; Barrett, P.H.; Purnell, J.Q.; Brunzell, J.D. The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J. Clin. Endocrinol. Metab. 2001, 86, 2831-2837.
72. Guendouzi, K.; Jaspard, B.; Barbaras, R.; Motta, C.; Vieu, C.; Marcel, Y.; Chap, H.; Perret, B.; Collet, X. Biochemical and physical properties of remnant-HDL2 and of pre beta 1-HDL produced by hepatic lipase. Biochemistry 1999, 38, 2762-2768.
73. De Souza, J.A.; Vindis, C.; Hansel, B.; Negre-Salvayre, A.; Therond, P.; Serrano, C.V., Jr.; Chantepie, S.; Salvayre, R.; Bruckert, E.; Chapman, M.J.; Kontush, A. Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity. Atherosclerosis 2008, 197, 84-94.