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Volumn 13, Issue 7, 2014, Pages 3455-3466

Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese

Author keywords

biomarkers; branched chain amino acids; metabolomics; microarray; subcutaneous adipose tissue; tricarboxylic acid cycle

Indexed keywords

ACETYLCARNITINE; ALANINE; AMINO ACID; AMINO ACID DERIVATIVE; ARGININE; ASPARAGINE; ASPARTIC ACID; CARNITINE; CITRULLINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HEMOGLOBIN A1C; HISTIDINE; HYDROXYPROLINE; HYPOXANTHINE; INSULIN; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; ORNITHINE; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRYPTOPHAN; TYROSINE; UNINDEXED DRUG; VALINE; BRANCHED CHAIN AMINO ACID;

EID: 84903692940     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500416v     Document Type: Article
Times cited : (104)

References (50)
  • 2
    • 25844457693 scopus 로고    scopus 로고
    • Obesity
    • Haslam, D. W.; James, W. P. T. Obesity Lancet 2005, 366 (9492) 1197-1209
    • (2005) Lancet , vol.366 , Issue.9492 , pp. 1197-1209
    • Haslam, D.W.1    James, W.P.T.2
  • 4
  • 5
    • 77957852860 scopus 로고    scopus 로고
    • Metabolically healthy obesity: Different prevalences using different criteria
    • Velho, S.; Paccaud, F.; Waeber, G.; Vollenweider, P.; Marques-Vidal, P. Metabolically healthy obesity: different prevalences using different criteria Eur. J. Clin. Nutr. 2010, 64 (10) 1043-1051
    • (2010) Eur. J. Clin. Nutr. , vol.64 , Issue.10 , pp. 1043-1051
    • Velho, S.1    Paccaud, F.2    Waeber, G.3    Vollenweider, P.4    Marques-Vidal, P.5
  • 6
    • 49249132007 scopus 로고    scopus 로고
    • Metabolically healthy but obese women: Effect of an energy-restricted diet
    • Karelis, A.; Messier, V.; Brochu, M.; Rabasa-Lhoret, R. Metabolically healthy but obese women: effect of an energy-restricted diet Diabetologia 2008, 51 (9) 1752-1754
    • (2008) Diabetologia , vol.51 , Issue.9 , pp. 1752-1754
    • Karelis, A.1    Messier, V.2    Brochu, M.3    Rabasa-Lhoret, R.4
  • 7
    • 33749126980 scopus 로고    scopus 로고
    • Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: Low inflammation and LDL oxidation in MHO women
    • Shin, M.; Hyun, Y.; Kim, O.; Kim, J.; Jang, Y.; Lee, J. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women Int. J. Obes. 2006, 30 (10) 1529-1534
    • (2006) Int. J. Obes. , vol.30 , Issue.10 , pp. 1529-1534
    • Shin, M.1    Hyun, Y.2    Kim, O.3    Kim, J.4    Jang, Y.5    Lee, J.6
  • 8
    • 84881167320 scopus 로고    scopus 로고
    • Changing trends in the prevalence and disparities of obesity and other cardiovascular disease risk factors in three racial/ethnic groups of USA adults
    • Romero, C.; Romero, T.; Shlay, J.; Ogden, L.; Dabelea, D. Changing trends in the prevalence and disparities of obesity and other cardiovascular disease risk factors in three racial/ethnic groups of USA adults Adv. Prev. Med. 2012, 2012, 172423
    • (2012) Adv. Prev. Med. , vol.2012 , pp. 172423
    • Romero, C.1    Romero, T.2    Shlay, J.3    Ogden, L.4    Dabelea, D.5
  • 11
    • 84875050927 scopus 로고    scopus 로고
    • Power of metabolomics in biomarker discovery and mining mechanisms of obesity
    • Zhang, A.; Sun, H.; Wang, X. Power of metabolomics in biomarker discovery and mining mechanisms of obesity Obes. Rev. 2013, 14 (4) 344-349
    • (2013) Obes. Rev. , vol.14 , Issue.4 , pp. 344-349
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 13
    • 84862282554 scopus 로고    scopus 로고
    • Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State
    • Adams, S. H. Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State Adv. Nutr. 2011, 2 (6) 445-456
    • (2011) Adv. Nutr. , vol.2 , Issue.6 , pp. 445-456
    • Adams, S.H.1
  • 14
    • 77956299196 scopus 로고    scopus 로고
    • Metabolic Profiling of Plasma in Overweight/Obese and Lean Men using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC-Q-TOF MS)
    • Kim, J. Y.; Park, J. Y.; Kim, O. Y.; Ham, B. M.; Kim, H.-J.; Kwon, D. Y.; Jang, Y.; Lee, J. H. Metabolic Profiling of Plasma in Overweight/Obese and Lean Men using Ultra Performance Liquid Chromatography and Q-TOF Mass Spectrometry (UPLC-Q-TOF MS) J. Proteome Res. 2010, 9 (9) 4368-4375
    • (2010) J. Proteome Res. , vol.9 , Issue.9 , pp. 4368-4375
    • Kim, J.Y.1    Park, J.Y.2    Kim, O.Y.3    Ham, B.M.4    Kim, H.-J.5    Kwon, D.Y.6    Jang, Y.7    Lee, J.H.8
  • 16
    • 84862287116 scopus 로고    scopus 로고
    • Investigating Potential Mechanisms of Obesity by Metabolomics
    • Xie, B.; Waters, M. J.; Schirra, H. J. Investigating Potential Mechanisms of Obesity by Metabolomics J. Biomed. Biotechnol. 2012, 2012, 10
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 10
    • Xie, B.1    Waters, M.J.2    Schirra, H.J.3
  • 21
    • 84895771789 scopus 로고    scopus 로고
    • A Distinct Fatty Acid Profile Underlies the Reduced Inflammatory State of Metabolically Healthy Obese Individuals
    • Perreault, M.; Zulyniak, M. A.; Badoud, F.; Stephenson, S.; Badawi, A.; Buchholz, A.; Mutch, D. M. A Distinct Fatty Acid Profile Underlies the Reduced Inflammatory State of Metabolically Healthy Obese Individuals PLoS One 2014, 9 (2) e88539
    • (2014) PLoS One , vol.9 , Issue.2 , pp. 88539
    • Perreault, M.1    Zulyniak, M.A.2    Badoud, F.3    Stephenson, S.4    Badawi, A.5    Buchholz, A.6    Mutch, D.M.7
  • 22
    • 84859224327 scopus 로고    scopus 로고
    • Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin
    • Shah, N. R.; Braverman, E. R. Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin PLoS One 2012, 7 (4) e33308
    • (2012) PLoS One , vol.7 , Issue.4 , pp. 33308
    • Shah, N.R.1    Braverman, E.R.2
  • 23
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification
    • Smith, C. A.; Want, E. J.; OMaille, G.; Abagyan, R.; Siuzdak, G. XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification Anal. Chem. 2006, 78 (3) 779-787
    • (2006) Anal. Chem. , vol.78 , Issue.3 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    Omaille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 24
    • 41149120242 scopus 로고    scopus 로고
    • Visualization of GC/TOF-MS-Based Metabolomics Data for Identification of Biochemically Interesting Compounds Using OPLS Class Models
    • Wiklund, S.; Johansson, E.; Sjostrom, L.; Mellerowicz, E. J.; Edlund, U.; Shockcor, J. P.; Gottfries, J.; Moritz, T.; Trygg, J. Visualization of GC/TOF-MS-Based Metabolomics Data for Identification of Biochemically Interesting Compounds Using OPLS Class Models Anal. Chem. 2007, 80 (1) 115-122
    • (2007) Anal. Chem. , vol.80 , Issue.1 , pp. 115-122
    • Wiklund, S.1    Johansson, E.2    Sjostrom, L.3    Mellerowicz, E.J.4    Edlund, U.5    Shockcor, J.P.6    Gottfries, J.7    Moritz, T.8    Trygg, J.9
  • 26
    • 84888337374 scopus 로고    scopus 로고
    • Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry: A High-Throughput Platform for Metabolomics with High Data Fidelity
    • Kuehnbaum, N. L.; Kormendi, A.; Britz-McKibbin, P. Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry: A High-Throughput Platform for Metabolomics with High Data Fidelity Anal. Chem. 2013, 85 (22) 10664-10669
    • (2013) Anal. Chem. , vol.85 , Issue.22 , pp. 10664-10669
    • Kuehnbaum, N.L.1    Kormendi, A.2    Britz-Mckibbin, P.3
  • 27
    • 84883156854 scopus 로고    scopus 로고
    • Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults
    • Liu, R. H.; Wharton, S.; Sharma, A. M.; Ardern, C. I.; Kuk, J. L. Influence of a clinical lifestyle-based weight loss program on the metabolic risk profile of metabolically normal and abnormal obese adults Obesity 2013, 21 (8) 1533-1539
    • (2013) Obesity , vol.21 , Issue.8 , pp. 1533-1539
    • Liu, R.H.1    Wharton, S.2    Sharma, A.M.3    Ardern, C.I.4    Kuk, J.L.5
  • 28
    • 84897065137 scopus 로고    scopus 로고
    • Intensive Lifestyle Intervention Improves Cardiometabolic and Exercise Parameters in Metabolically Healthy Obese and Metabolically Unhealthy Obese Individuals
    • Dalzill, C.; Nigam, A.; Juneau, M.; Guilbeault, V.; Latour, E.; Mauriège, P.; Gayda, M. Intensive Lifestyle Intervention Improves Cardiometabolic and Exercise Parameters in Metabolically Healthy Obese and Metabolically Unhealthy Obese Individuals Can. J. Cardiol. 2014, 30, 434-440
    • (2014) Can. J. Cardiol. , vol.30 , pp. 434-440
    • Dalzill, C.1    Nigam, A.2    Juneau, M.3    Guilbeault, V.4    Latour, E.5    Mauriège, P.6    Gayda, M.7
  • 30
    • 84885206610 scopus 로고    scopus 로고
    • Does Inflammation Determine Metabolic Health Status in Obese and Nonobese Adults?
    • Phillips, C. M.; Perry, I. J. Does Inflammation Determine Metabolic Health Status in Obese and Nonobese Adults? J. Clin. Endocrinol. Metab. 2013, 98 (10) E1610-E1619
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , Issue.10
    • Phillips, C.M.1    Perry, I.J.2
  • 31
    • 84883162867 scopus 로고    scopus 로고
    • Predictors of obesity: The "power" of the omics
    • Ordovás Mun∼oz, J. Predictors of obesity: the "power" of the omics Nutr. Hosp. 2013, 5, 63-71
    • (2013) Nutr. Hosp. , vol.5 , pp. 63-71
    • Ordovás Munoz, J.1
  • 32
    • 78650732495 scopus 로고    scopus 로고
    • Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women
    • Fiehn, O.; Garvey, W. T.; Newman, J. W.; Lok, K. H.; Hoppel, C. L.; Adams, S. H. Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women PLoS One 2010, 5 (12) e15234
    • (2010) PLoS One , vol.5 , Issue.12 , pp. 15234
    • Fiehn, O.1    Garvey, W.T.2    Newman, J.W.3    Lok, K.H.4    Hoppel, C.L.5    Adams, S.H.6
  • 37
    • 84876118914 scopus 로고    scopus 로고
    • New Advances in Separation Science for Metabolomics: Resolving Chemical Diversity in a Post-Genomic Era
    • Kuehnbaum, N. L.; Britz-McKibbin, P. New Advances in Separation Science for Metabolomics: Resolving Chemical Diversity in a Post-Genomic Era Chem. Rev. 2013, 113 (4) 2437-2468
    • (2013) Chem. Rev. , vol.113 , Issue.4 , pp. 2437-2468
    • Kuehnbaum, N.L.1    Britz-Mckibbin, P.2
  • 39
    • 84878494552 scopus 로고    scopus 로고
    • Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics
    • Xu, F.; Tavintharan, S.; Sum, C. F.; Woon, K.; Lim, S. C.; Ong, C. N. Metabolic Signature Shift in Type 2 Diabetes Mellitus Revealed by Mass Spectrometry-based Metabolomics J. Clin. Endocrinol. Metab. 2013, 98 (6) E1060-E1065
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , Issue.6
    • Xu, F.1    Tavintharan, S.2    Sum, C.F.3    Woon, K.4    Lim, S.C.5    Ong, C.N.6
  • 43
    • 84859073302 scopus 로고    scopus 로고
    • Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth with Obesity and Type 2 Diabetes: Evidence for enhanced mitochondrial oxidation
    • Mihalik, S. J.; Michaliszyn, S. F.; de las Heras, J.; Bacha, F.; Lee, S.; Chace, D. H.; DeJesus, V. R.; Vockley, J.; Arslanian, S. A. Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth With Obesity and Type 2 Diabetes: Evidence for enhanced mitochondrial oxidation Diabetes Care 2012, 35 (3) 605-611
    • (2012) Diabetes Care , vol.35 , Issue.3 , pp. 605-611
    • Mihalik, S.J.1    Michaliszyn, S.F.2    De Las Heras, J.3    Bacha, F.4    Lee, S.5    Chace, D.H.6    Dejesus, V.R.7    Vockley, J.8    Arslanian, S.A.9
  • 44
    • 84896283941 scopus 로고    scopus 로고
    • Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells
    • Chen, J.; Meng, Y.; Zhou, J.; Zhuo, M.; Ling, F.; Zhang, Y.; Du, H.; Wang, X. Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells J. Diabetes Res. 2013, 2013, 9
    • (2013) J. Diabetes Res. , vol.2013 , pp. 9
    • Chen, J.1    Meng, Y.2    Zhou, J.3    Zhuo, M.4    Ling, F.5    Zhang, Y.6    Du, H.7    Wang, X.8
  • 45
    • 84859204479 scopus 로고    scopus 로고
    • Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects
    • Soronen, J.; Laurila, P.-P.; Naukkarinen, J.; Surakka, I.; Ripatti, S.; Jauhiainen, M.; Olkkonen, V.; Yki-Jarvinen, H. Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects BMC Med. Genomics 2012, 5 (1) 9
    • (2012) BMC Med. Genomics , vol.5 , Issue.1 , pp. 9
    • Soronen, J.1    Laurila, P.-P.2    Naukkarinen, J.3    Surakka, I.4    Ripatti, S.5    Jauhiainen, M.6    Olkkonen, V.7    Yki-Jarvinen, H.8
  • 47
    • 84874410516 scopus 로고    scopus 로고
    • Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients
    • Qatanani, M.; Tan, Y.; Dobrin, R.; Greenawalt, D. M.; Hu, G.; Zhao, W.; Olefsky, J. M.; Sears, D. D.; Kaplan, L. M.; Kemp, D. M. Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients Diabetes 2013, 62 (3) 855-863
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 855-863
    • Qatanani, M.1    Tan, Y.2    Dobrin, R.3    Greenawalt, D.M.4    Hu, G.5    Zhao, W.6    Olefsky, J.M.7    Sears, D.D.8    Kaplan, L.M.9    Kemp, D.M.10
  • 48
    • 0037163021 scopus 로고    scopus 로고
    • The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function
    • Owen, O. E.; Kalhan, S. C.; Hanson, R. W. The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function J. Biol. Chem. 2002, 277 (34) 30409-30412
    • (2002) J. Biol. Chem. , vol.277 , Issue.34 , pp. 30409-30412
    • Owen, O.E.1    Kalhan, S.C.2    Hanson, R.W.3
  • 49
    • 84875840347 scopus 로고    scopus 로고
    • Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype
    • Flachs, P.; Rossmeisl, M.; Kuda, O.; Kopecky, J. Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 2013, 1831 (5) 986-1003
    • (2013) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids , vol.1831 , Issue.5 , pp. 986-1003
    • Flachs, P.1    Rossmeisl, M.2    Kuda, O.3    Kopecky, J.4
  • 50
    • 84862555712 scopus 로고    scopus 로고
    • Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: Marker or maker of the diabetic phenotype?
    • Gaster, M.; Nehlin, J. O.; Minet, A. D. Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: Marker or maker of the diabetic phenotype? Arch. Physiol. Biochem. 2012, 118 (3) 156-189-189
    • (2012) Arch. Physiol. Biochem. , vol.118 , Issue.3 , pp. 156
    • Gaster, M.1    Nehlin, J.O.2    Minet, A.D.3


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