CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 39, 2016, Pages 10956-10961

  Bernard Valnet, Raphaël ^a   Yshii, Lidia ^a   Quériault, Clémence ^a   Nguyen, Xuan Hung ^a   Arthaud, Sébastien ^b   Rodrigues, Magda ^a   Canivet, Astrid ^a   Morel, Anne Laure ^b   Matthys, Arthur ^a   Bauer, Jan ^c   Pignolet, Béatrice ^a   Dauvilliers, Yves ^d   Peyron, Christelle ^b   Liblaua, Roland S ^a,e  

^a Université Paul Sabatier   (France)

^b LYON NEUROSCIENCE RESEARCH CENTER   (France)

^c Medical University of Vienna   (Austria)

^d GUI DE CHAULIAC HOSPITAL   (France)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Autoimmunity; Cd8 T cells; Narcolepsy; Orexin; Sleep disorders

Indexed keywords

CD11B ANTIGEN; CD4 ANTIGEN; HLA ANTIGEN; OREXIN; AUTOANTIBODY; AUTOANTIGEN; HEMAGGLUTININ;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CATAPLEXY; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL KILLING; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE COURSE; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; ENVIRONMENTAL FACTOR; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLUENZA A VIRUS (H1N1); MACROPHAGE; MOUSE; NARCOLEPSY; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PHENOTYPE; POLARIZATION; PRIORITY JOURNAL; TH1 CELL; ANIMAL; C57BL MOUSE; CELL COMMUNICATION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HYPOTHALAMUS; IMMUNOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CYTOTOXICITY, IMMUNOLOGIC; HEMAGGLUTININS; HYPOTHALAMUS; INFLAMMATION; MACROPHAGES; MICE, INBRED C57BL; NARCOLEPSY; NEURONS; OREXINS; PHENOTYPE; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS;

EID: 84989887016     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603325113     Document Type: Article

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