Conditional ablation of orexin/hypocretin neurons: A new mouse model for the study of narcolepsy and orexin system function

Journal of Neuroscience

Volumn 34, Issue 19, 2014, Pages 6495-6509

  Tabuchi, Sawako ^a,b,c   Tsunematsu, Tomomi ^a,c   Black, Sarah W ^d   Tominaga, Makoto ^b,e   Maruyama, Megumi ^a,e   Takagi, Kazuyo ^b,e   Minokoshi, Yasuhiko ^b,e   Sakurai, Takeshi ^f   Kilduff, Thomas S ^d   Yamanaka, Akihiro ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d SRI INTERNATIONAL   (United States)

^e NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^f KANAZAWA UNIVERSITY   (Japan)

Author keywords

Diphtheria toxin A fragment; Hypocretin; Model mice; Narcolepsy; Orexin; Transgenic

Indexed keywords

DIPHTHERIA TOXIN; DOXYCYCLINE; GHRELIN; LEPTIN; OREXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CATAPLEXY; CELL LOSS; CONTROLLED STUDY; DIETARY INTAKE; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; FEMALE; FOOD INTAKE; GENE EXPRESSION; HOX GENE; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE; NARCOLEPSY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SLEEP WAKING CYCLE;

DIPHTHERIA TOXIN A FRAGMENT; HYPOCRETIN; MODEL MICE; NARCOLEPSY; OREXIN; TRANSGENIC;

ANIMALS; BODY WEIGHT; CATAPLEXY; DIPHTHERIA TOXIN; DISEASE MODELS, ANIMAL; DOXYCYCLINE; DRINKING; EATING; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; FEMALE; FOOD; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NARCOLEPSY; NEURONS; NEUROPEPTIDES; SLEEP; WAKEFULNESS;

EID: 84899855138     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0073-14.2014     Document Type: Article

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