Narcolepsy-associated HLA class I alleles implicate cell-mediated cytotoxicity

Sleep

Volumn 39, Issue 3, 2016, Pages 581-587

  Tafti, Mehdi ^a,b   Lammers, Gert J ^c,d   Dauvilliers, Yves ^e,f   Overeem, Sebastiaan ^g   Mayer, Geert ^h   Nowak, Jacek ⁱ   Pfister, Corinne ^a   Dubois, Valérie ^j   Eliaou, Jean François ^k   Eberhard, Hans Peter ^l   Liblau, Roland ^m   Wierzbicka, Aleksandra ⁿ   Geisler, Peter ^o   Bassetti, Claudio L ^p   Mathis, Johannes ^p   Lecendreux, Michel ^q   Khatami, Ramin ^r   Heinzer, Raphaël ^b   Haba Rubio, José ^b   Feketeova, Eva ^s   Baumann, Christian R ^t   Kutalik, Zoltán ^u,v   Tiercy, Jean Marie ^w   more..

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^e INSERM U1061   (France)

^f GUI DE CHAULIAC HOSPITAL   (France)

^g EPILEPSY CENTER KEMPENHAEGHE   (Netherlands)

^h Hephata Clinic for Neurology   (Germany)

ⁱ INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

^j ETABLISSEMENT FRANÇAIS DU SANG   (France)

^k UNIV MONTPELLIER   (France)

^l German National Bone Marrow Donor Registry   (Germany)

^m France   (France)

ⁿ INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^o UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^p UNIVERSITY OF BERN   (Switzerland)

^q HÔPITAL ROBERT DEBRÉ   (France)

^r Clinic Barmelweid   (Switzerland)

^s P J AFÁRIK UNIVERSITY   (Slovakia)

^t UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^u SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^v UNIVERSITY OF LAUSANNE   (Switzerland)

^w GENEVA UNIVERSITY HOSPITALS   (Switzerland)

more..

Author keywords

Autoimmunity; CD4; CD8; Cytotoxicity; Hypocretin orexin

Indexed keywords

HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; HLA C ANTIGEN; HLA DPB1 ANTIGEN; HLA DQB1 ANTIGEN; T LYMPHOCYTE RECEPTOR; EPITOPE; HLA DQ ANTIGEN; HLA-DQB1 ANTIGEN; OREXIN;

ANTIGEN PRESENTATION; ARTICLE; CATAPLEXY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENOTYPE; HAPLOTYPE; HUMAN; IMMUNOLOGICAL TOLERANCE; MAJOR CLINICAL STUDY; NARCOLEPSY; PRIORITY JOURNAL; ALLELE; CASE CONTROL STUDY; CAUCASIAN; CYTOTOXIC T LYMPHOCYTE; ETHNOLOGY; EUROPE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; NERVE CELL; ODDS RATIO; PATHOLOGY;

ALLELES; CASE-CONTROL STUDIES; CATAPLEXY; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-DQ BETA-CHAINS; HUMANS; LINKAGE DISEQUILIBRIUM; NEURONS; ODDS RATIO; OREXINS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84960462903     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.5532     Document Type: Article

References (32)

1. Juji T, Satake M, Honda Y, Doi Y. HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. Tissue Antigens 1984;24:316-9.
2. Nishino S, Ripley B, Overeem S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000;355:39-40.
3. Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000;6:991-7.
4. Cvetkovic-Lopes V, Bayer L, Dorsaz S, et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest 2010;120:713-9.
5. Liblau RS, Vassalli A, Seifinejad A, Tafti M. Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy. Lancet Neurol 2015;14:318-28.
6. Dauvilliers Y, Bauer J, Rigau V, et al. Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy. JAMA Neurol 2013;70:1305-10.
7. Tafti M, Hor H, Dauvilliers Y, et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe. Sleep 2014;37:19-25.
8. Hor H, Kutalik Z, Dauvilliers Y, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet 2010;42:786-9.
9. Seignalet J, Billiard M. Possible association between HLA-B7 and narcolepsy. Tissue Antigens 1984;23:188-9.
10. Mueller-Eckhardt G, Meier-Ewert K, Schendel DJ, Reinecker FB, Multhoff G, Mueller-Eckhardt C. HLA and narcolepsy in a German population. Tissue Antigens 1986;28:163-9.
11. Poirier G, Montplaisir J, Decary F, Momege D, Lebrun A. HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. Sleep 1986;9:153-8.
12. Matsuki K, Juji T, Tokunaga K, Naohara T, Satake M, Honda Y. Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics. J Clin Invest 1985;76:2078-83.
13. Ollila HM, Ravel JM, Han F, et al. HLA-DPB1 and HLA Class I confer risk of and protection from narcolepsy. Am J Hum Genet 2015;96:136-46.
14. Cebrian C, Zucca FA, Mauri P, et al. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nat Commun 2014;5:3633.
15. Noble JA, Valdes AM, Varney MD, et al. HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes 2010;59:2972-9.
16. Sawcer S, Hellenthal G, Pirinen M, et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214-9.
17. Luca G, Haba-Rubio J, Dauvilliers Y, et al. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. J Sleep Res 2013;22:482-95.
18. Nowak J, Mika-Witkowska R, Mendek-Czajkowska E, et al. Association of HLA haplotypes with paroxysmal nocturnal hemoglobinuria. Transplant Proc 2010;42:3266-70.
19. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001;68:978-89.
20. Nathan M. Chi-square tests with one degree of freedom; extensions of the Mantel-Haenszel Procedure. J Am Statistical Assoc 1963;58:90-700.
21. Gao X, Starmer J, Martin ER. A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet Epidemiol 2008;32:361-9.
22. Saxena A, Martin-Blondel G, Mars LT, Liblau RS. Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis. FEBS Lett 2011;585:3758-63.
23. Hickman HD, Luis AD, Buchli R, et al. Toward a definition of self: proteomic evaluation of the class I peptide repertoire. J Immunol 2004;172:2944-52.
24. Barber LD, Gillece-Castro B, Percival L, Li X, Clayberger C, Parham P. Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes. Curr Biol 1995;5:179-90.
25. Chicz RM, Urban RG, Gorga JC, Vignali DA, Lane WS, Strominger JL. Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med 1993;178:27-47.
26. Jiang H, Wu Y, Liang B, et al. An affinity/avidity model of peripheral T cell regulation. J Clin Invest 2005;115:302-12.
27. Jones DC, Kosmoliaptsis V, Apps R, et al. H LA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding. J Immunol 2011;186:2990-7.
28. Pettersen EF, Goddard TD, Huang CC, et al. UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 2004;25:1605-12.
29. Berman HM, Westbrook J, Feng Z, et al. The protein data bank. Nucleic Acids Res 2000;28:235-42.
30. ∗1101 in complex with SARS nucleocapsid peptide. Acta Crystallogr D Biol Crystallogr 2005;61:1031-40.
31. Gras S, Kedzierski L, Valkenburg SA, et al. Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc Natl Acad Sci U S A 2010;107:12599-604.
32. Fan QR, Long EO, Wiley DC. Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol 2001;2:452-60.