Cutting edge: Neuronal recognition by CD8 T cells elicits central diabetes insipidus

Journal of Immunology

Volumn 188, Issue 10, 2012, Pages 4731-4735

  Scheikl, Tanja ^a,b,c   Pignolet, Béatrice ^a,b,c   Dalard, Cécile ^a,b,c   Desbois, Sabine ^a,b,c   Raison, Danièle ^d   Yamazaki, Masanori ^e   Saoudi, Abdelhadi ^a,b,c   Bauer, Jan ^f   Lassmann, Hans ^f   Hardin Pouzet, Hélène ^d   Liblau, Roland S ^a,b,c,g  

^a France   (France)

^b CNRS   (France)

^c UNIVERSITÉ PAUL SABATIER   (France)

^d INSERM   (France)

^e SHINSHU UNIVERSITY   (Japan)

^f Medical University of Vienna   (Austria)

^g CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INFLUENZA VIRUS HEMAGGLUTININ; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TUMOR NECROSIS FACTOR ALPHA; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES INSIPIDUS; ENCEPHALOMYELITIS; HYPOTHALAMUS; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; UPREGULATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DIABETES INSIPIDUS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS; GENES, MHC CLASS I; HUMANS; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; NEURONS; VASOPRESSINS;

EID: 84861176264     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102998     Document Type: Article

References (16)

1. Münz, C., J. D. Lünemann, M. T. Getts, and S. D. Miller. 2009. Antiviral immune responses: triggers of or triggered by autoimmunity? Nat. Rev. Immunol. 9: 246-258.
2. Bhat, R., and L. Steinman. 2009. Innate and adaptive autoimmunity directed to the central nervous system. Neuron 64: 123-132.
3. Melzer, N., S. G. Meuth, and H. Wiendl. 2009. CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability. FASEB J. 23: 3659-3673.
4. Darnell, R. B., and J. B. Posner. 2003. Paraneoplastic syndromes involving the nervous system. N. Engl. J. Med. 349: 1543-1554. (Pubitemid 37255041)
5. Vincent, A., C. G. Bien, S. R. Irani, and P. Waters. 2011. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol. 10: 759-772.
6. Mars, L. T., P. Saikali, R. S. Liblau, and N. Arbour. 2011. Contribution of CD8 T lymphocytes to the immuno-pathogenesis of multiple sclerosis and its animal models. Biochim. Biophys. Acta 1812: 151-161.
7. Casanova, E., S. Fehsenfeld, T. Mantamadiotis, T. Lemberger, E. Greiner, A. F. Stewart, and G. Schütz. 2001. A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis 31: 37-42. (Pubitemid 32927797)
8. Saxena, A., J. Bauer, T. Scheikl, J. Zapulla, M. Audebert, S. Desbois, A. Waisman, H. Lassmann, R. S. Liblau, and L. T. Mars. 2008. Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes. J. Immunol. 181: 1617-1621.
9. Maghnie, M. 2003. Diabetes insipidus. Horm. Res. 59: 42-54.
10. Rostène, W., P. Kiabgi, and S. M. Parsadaniantz. 2007. Chemokines: a new class of neuromodulator. Nat. Rev. Neurosci. 8: 895-904.
11. Schultzberg, M., T. Olsson, E. B. Samuelsson, J. Maehlen, and K. Kristensson. 1989. Early major histocompatibility complex (MHC) class I antigen induction in hypothalamic supraoptic and paraventricular nuclei in trypanosome-infected rats. J. Neuroimmunol. 24: 105-112. (Pubitemid 19269305)
12. Waki, K., S. Yamada, Y. Ozawa, K. Seki, and Y. Endo. 1999. A case of lymphocytic infundibuloneurohypophysitis: histophathological studies. Pituitary 1: 285-290.
13. Kojima, H., T. Nojima, K. Nagashima, Y. Ono, M. Kudo, and M. Ishikura. 1989. Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis. Arch. Pathol. Lab. Med. 113: 1399-1401. (Pubitemid 20027940)
14. Maghnie, M., S. Ghirardello, A. De Bellis, N. di Iorgi, L. Ambrosini, A. Secco, M. De Amici, C. Tinelli, A. Bellastella, and R. Lorini. 2006. Idiopathic central diabetes insipidus in children and young adults is commonly associated with vasopressin-cell antibodies and markers of autoimmunity. Clin. Endocrinol. (Oxf.) 65: 470-478. (Pubitemid 44414270)
15. Husebye, E. S., J. Perheentupa, R. Rautemaa, and O. Kämpe. 2009. Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I. J. Intern. Med. 265: 514-529.
16. Dillard, T., C. G. Yedinak, J. Alumkal, and M. Fleseriu. 2010. Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13: 29-38.