HLA-DPB1 and HLA class i confer risk of and protection from narcolepsy

American Journal of Human Genetics

Volumn 96, Issue 1, 2015, Pages 136-146

  Ollila, Hanna M ^a   Ravel, Jean Marie ^a   Han, Fang ^b   Faraco, Juliette ^a   Lin, Ling ^a   Zheng, Xiuwen ^c   Plazzi, Giuseppe ^d,e   Dauvilliers, Yves ^f   Pizza, Fabio ^d,e   Hong, Seung Chul ^g   Jennum, Poul ^h   Knudsen, Stine ⁱ   Kornum, Birgitte R ^h,j   Dong, Xiao Song ^b   Yan, Han ^b   Hong, Heeseung ^a   Coquillard, Cristin ^k   Mahlios, Joshua ^a   Jolanki, Otto ^a   Einen, Mali ^a   Lavault, Sophie ^l   Högl, Birgit ^m   Frauscher, Birgit ^m   Crowe, Catherine ⁿ   Partinen, Markku ^o,p   Huang, Yu Shu ^q   Bourgin, Patrice ^r   Vaarala, Outi ^p   Désautels, Alex ^s   Montplaisir, Jacques ^s   Mack, Steven J ^t   Mindrinos, Michael ^k   Fernandez Vina, Marcelo ^k   Mignot, Emmanuel ^a   more..

^a STANFORD UNIVERSITY   (United States)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e IRCCS ISTITUTO DELLE SCIENZE NEUROLOGICHE DI BOLOGNA   (Italy)

^f GUI DE CHAULIAC HOSPITAL   (France)

^g The Catholic University of Korea   (South Korea)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

ⁱ ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^j GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^k STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l HÔpital Robert Debré   (France)

^m INNSBRUCK MEDICAL UNIVERSITY   (Austria)

ⁿ Mater Private Hospital   (Ireland)

^o Vitalmed Research Centre   (Finland)

^p UNIVERSITY OF HELSINKI   (Finland)

^q CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^r UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^s HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^t CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B ANTIGEN; HLA DPB1 ANTIGEN; HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DRB1 ANTIGEN; HLA DP ANTIGEN; HLA-DPB1 ANTIGEN; HLA-DQA1 ANTIGEN;

ALLELE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETHNIC GROUP; EUROPEAN; GENOTYPE; HLA SYSTEM; HLA TYPING; HUMAN; MAJOR CLINICAL STUDY; NARCOLEPSY; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT INFECTION; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CAUCASIAN; COHORT ANALYSIS; FEMALE; GENE LOCUS; GENETICS; HAPLOTYPE; INFLUENZA A VIRUS (H1N1); MALE; METABOLISM; RISK FACTOR;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-B ANTIGENS; HLA-DP ANTIGENS; HLA-DP BETA-CHAINS; HLA-DQ ALPHA-CHAINS; HLA-DR ANTIGENS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MALE; NARCOLEPSY; RISK FACTORS;

EID: 84920733875     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2014.12.010     Document Type: Article

References (60)

1. C. Peyron, J. Faraco, W. Rogers, B. Ripley, S. Overeem, Y. Charnay, S. Nevsimalova, M. Aldrich, D. Reynolds, and R. Albin A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nat. Med. 6 2000 991 997
2. ∗0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups Tissue Antigens 51 1998 96 100
3. F. Han, L. Lin, J. Li, S.X. Dong, P. An, L. Zhao, N.Y. Liu, Q.Y. Li, H. Yan, and Z.C. Gao HLA-DQ association and allele competition in Chinese narcolepsy Tissue Antigens 80 2012 328 335
4. B.R. Kornum, M. Kawashima, J. Faraco, L. Lin, T.J. Rico, S. Hesselson, R.C. Axtell, H. Kuipers, K. Weiner, and A. Hamacher Common variants in P2RY11 are associated with narcolepsy Nat. Genet. 43 2011 66 71
5. F. Han, J. Faraco, X.S. Dong, H.M. Ollila, L. Lin, J. Li, P. An, S. Wang, K.W. Jiang, and Z.C. Gao Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic PLoS Genet. 9 2013 e1003880
6. J. Hallmayer, J. Faraco, L. Lin, S. Hesselson, J. Winkelmann, M. Kawashima, G. Mayer, G. Plazzi, S. Nevsimalova, and P. Bourgin Narcolepsy is strongly associated with the T-cell receptor alpha locus Nat. Genet. 41 2009 708 711
7. Y. Dauvilliers, S. Maret, C. Bassetti, B. Carlander, M. Billiard, J. Touchon, and M. Tafti A monozygotic twin pair discordant for narcolepsy and CSF hypocretin-1 Neurology 62 2004 2137 2138
8. F. Han, L. Lin, S.C. Warby, J. Faraco, J. Li, S.X. Dong, P. An, L. Zhao, L.H. Wang, and Q.Y. Li Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China Ann. Neurol. 70 2011 410 417
9. A. Aran, L. Lin, S. Nevsimalova, G. Plazzi, S.C. Hong, K. Weiner, J. Zeitzer, and E. Mignot Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset Sleep 32 2009 979 983
10. H. Wu, J. Zhuang, W.S. Stone, L. Zhang, Z. Zhao, Z. Wang, Y. Yang, X. Li, X. Zhao, and Z. Zhao Symptoms and occurrences of narcolepsy: a retrospective study of 162 patients during a 10-year period in eastern China Sleep Med. 15 2014 607 613
11. M. Partinen, O. Saarenpää-Heikkilä, I. Ilveskoski, C. Hublin, M. Linna, P. Olsén, P. Nokelainen, R. Alén, T. Wallden, and M. Espo Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland PLoS ONE 7 2012 e33723
12. H. Nohynek, J. Jokinen, M. Partinen, O. Vaarala, T. Kirjavainen, J. Sundman, S.L. Himanen, C. Hublin, I. Julkunen, and P. Olsén AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland PLoS ONE 7 2012 e33536
13. D. O'Flanagan, A.S. Barret, M. Foley, S. Cotter, C. Bonner, C. Crowe, B. Lynch, B. Sweeney, H. Johnson, B. McCoy, and E. Purcell Investigation of an association between onset of narcolepsy and vaccination with pandemic influenza vaccine, Ireland April 2009-December 2010 Euro Surveill. 19 2014 15 25
14. I. Persson, F. Granath, J. Askling, J.F. Ludvigsson, T. Olsson, and N. Feltelius Risks of neurological and immune-related diseases, including narcolepsy, after vaccination with Pandemrix: a population- and registry-based cohort study with over 2 years of follow-up J. Intern. Med. 275 2014 172 190
15. E. Miller, N. Andrews, L. Stellitano, J. Stowe, A.M. Winstone, J. Shneerson, and C. Verity Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis BMJ 346 2013 f794
16. Y. Dauvilliers, I. Arnulf, M. Lecendreux, C. Monaca Charley, P. Franco, X. Drouot, M.P. d'Ortho, S. Launois, S. Lignot, P. Bourgin Narcoflu-VF study group Increased risk of narcolepsy in children and adults after pandemic H1N1 vaccination in France Brain 136 2013 2486 2496
17. M.S. Heier, K.M. Gautvik, E. Wannag, K.H. Bronder, E. Midtlyng, Y. Kamaleri, and J. Storsaeter Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A Sleep Med. 14 2013 867 871
18. J. Montplaisir, D. Petit, M.-J. Quinn, M. Ouakki, G. Deceuninck, A. Desautels, E. Mignot, and P. De Wals Risk of narcolepsy associated with inactivated adjuvanted (AS03) A/H1N1 (2009) pandemic influenza vaccine in Quebec PLoS ONE 9 2014 e108489
19. K. Matsuki, F.C. Grumet, X. Lin, M. Gelb, C. Guilleminault, W.C. Dement, and E. Mignot DQ (rather than DR) gene marks susceptibility to narcolepsy Lancet 339 1992 1052
20. ∗0602 - positive subjects Hum. Immunol. 67 2006 749 755
21. S.C. Hong, Leen-Kim, S.A. Park, J.H. Han, S.P. Lee, L. Lin, M. Okun, S. Nishino, and E. Mignot HLA and hypocretin studies in Korean patients with narcolepsy Sleep 25 2002 440 444
22. E. Mignot, L. Lin, W. Rogers, Y. Honda, X. Qiu, X. Lin, M. Okun, H. Hohjoh, T. Miki, and S. Hsu Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups Am. J. Hum. Genet. 68 2001 686 699
23. E. Mignot, L. Lin, and H. Li HLA allele and microsatellite studies in narcolepsy J. Hansen, B. Dupont, HLA 2004, Immunobiology of the Human MHC, Proceedings of the 13th International Histocompatibility Workshop and Congress 2006 IHWG Press Seattle 817 823
24. F. Megiorni, and A. Pizzuti HLA-DQA1 and HLA-DQB1 in Celiac disease predisposition: practical implications of the HLA molecular typing J. Biomed. Sci. 19 2012 88
25. P. Eerligh, M. van Lummel, A. Zaldumbide, A.K. Moustakas, G. Duinkerken, G. Bondinas, B.P. Koeleman, G.K. Papadopoulos, and B.O. Roep Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes Genes Immun. 12 2011 415 427
26. H.M. Ollila, M. Fernandez-Vina, and E. Mignot HLA-DQ allele competition in narcolepsy: A comment on Tafti et al. DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe Sleep 2014 Published online October 17, 2014
27. ∗0601 modulate narcolepsy susceptibility in Koreans Hum. Immunol. 68 2007 59 68
28. ∗0602 Tissue Antigens 57 2001 230 235
29. M. Tafti, H. Hor, Y. Dauvilliers, G.J. Lammers, S. Overeem, G. Mayer, S. Javidi, A. Iranzo, J. Santamaria, and R. Peraita-Adrados DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe Sleep 37 2014 19 25
30. W.W. Kwok, S. Kovats, P. Thurtle, and G.T. Nepom HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation J. Immunol. 150 1993 2263 2272
31. S. Sugihara, T. Ogata, T. Kawamura, T. Urakami, K. Takemoto, N. Kikuchi, N. Takubo, K. Tsubouchi, R. Horikawa, K. Kobayashi Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families Pediatr. Diabetes 13 2012 33 44
32. N.A. Patsopoulos, L.F. Barcellos, R.Q. Hintzen, C. Schaefer, C.M. van Duijn, J.A. Noble, T. Raj, P.A. Gourraud, B.E. Stranger, J. Oksenberg IMSGC ANZgene Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects PLoS Genet. 9 2013 e1003926
33. M.D. Varney, A.M. Valdes, J.A. Carlson, J.A. Noble, B.D. Tait, P. Bonella, E. Lavant, A.L. Fear, A. Louey, P. Moonsamy Type 1 Diabetes Genetics Consortium HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families Diabetes 59 2010 2055 2062
34. H. Luo, M. Chen, Z. Cui, R. Yang, P.C. Xu, X.J. Zhou, and M.H. Zhao The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients BMC Nephrol. 12 2011 21
35. T. Horiki, H. Inoko, J. Moriuchi, Y. Ichikawa, and S. Arimori Combinations of HLA-DPB1 and HLA-DQB1 alleles determine susceptibility to early-onset myasthenia gravis in Japan Autoimmunity 19 1994 49 54
36. A.J. Moss, F.P. Gaughran, A. Karasu, A.S. Gilbert, A.J. Mann, C.M. Gelder, J.S. Oxford, H.A. Stephens, and R. Lambkin-Williams Correlation between human leukocyte antigen class II alleles and HAI titers detected post-influenza vaccination PLoS ONE 8 2013 e71376
37. N. Nishida, H. Sawai, K. Kashiwase, M. Minami, M. Sugiyama, W.K. Seto, M.F. Yuen, N. Posuwan, Y. Poovorawan, and S.H. Ahn New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia PLoS ONE 9 2014 e86449
38. Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, and H. Kumada A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians Nat. Genet. 41 2009 591 595
39. J. Faraco, L. Lin, B.R. Kornum, E.E. Kenny, G. Trynka, M. Einen, T.J. Rico, P. Lichtner, Y. Dauvilliers, and I. Arnulf ImmunoChip study implicates antigen presentation to T cells in narcolepsy PLoS Genet. 9 2013 e1003270
40. American Academy of Sleep Medicine The International Classification of Sleep Disorders, Third Edition 2014 American Academy of Sleep Medicine Chicago
41. C. Wang, S. Krishnakumar, J. Wilhelmy, F. Babrzadeh, L. Stepanyan, L.F. Su, D. Levinson, M.A. Fernandez-Viña, R.W. Davis, M.M. Davis, and M. Mindrinos High-throughput, high-fidelity HLA genotyping with deep sequencing Proc. Natl. Acad. Sci. USA 109 2012 8676 8681
42. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, and P.C. Sham PLINK: a tool set for whole-genome association and population-based linkage analyses Am. J. Hum. Genet. 81 2007 559 575
43. R Development Core Team R: A language and environment for statistical computing 2010 R Foundation for Statistical Computing Vienna
44. X. Zheng, J. Shen, C. Cox, J.C. Wakefield, M.G. Ehm, M.R. Nelson, and B.S. Weir HIBAG - HLA genotype imputation with attribute bagging Pharmacogenomics J. 14 2014 192 200
45. X. Jia, B. Han, S. Onengut-Gumuscu, W.M. Chen, P.J. Concannon, S.S. Rich, S. Raychaudhuri, and P.I. de Bakker Imputing amino acid polymorphisms in human leukocyte antigens PLoS ONE 8 2013 e64683
46. S.S. Rich, P. Concannon, H. Erlich, C. Julier, G. Morahan, J. Nerup, F. Pociot, and J.A. Todd The Type 1 Diabetes Genetics Consortium Ann. N Y Acad. Sci. 1079 2006 1 8
47. J.A. Hollenbach, A. Madbouly, L. Gragert, C. Vierra-Green, S. Flesch, S. Spellman, A. Begovich, H. Noreen, E. Trachtenberg, and T. Williams A combined DPA1∼DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer Immunogenetics 64 2012 559 569
48. R.J. Pruim, R.P. Welch, S. Sanna, T.M. Teslovich, P.S. Chines, T.P. Gliedt, M. Boehnke, G.R. Abecasis, and C.J. Willer LocusZoom: regional visualization of genome-wide association scan results Bioinformatics 26 2010 2336 2337
49. J.A. Hollenbach, S.J. Mack, G. Thomson, and P.A. Gourraud Analytical methods for disease association studies with immunogenetic data Methods Mol. Biol. 882 2012 245 266
50. R. Mägi, and A.P. Morris GWAMA: software for genome-wide association meta-analysis BMC Bioinformatics 11 2010 288
51. A.B. Begovich, P.V. Moonsamy, S.J. Mack, L.F. Barcellos, L.L. Steiner, S. Grams, V. Suraj-Baker, J. Hollenbach, E. Trachtenberg, and L. Louie Genetic variability and linkage disequilibrium within the HLA-DP region: analysis of 15 different populations Tissue Antigens 57 2001 424 439
52. T. Miyagawa, H. Toyoda, A. Hirataka, T. Kanbayashi, A. Imanishi, Y. Sagawa, N. Kotorii, T. Kotorii, Y. Hashizume, and K. Ogi New susceptibility variants to narcolepsy identified in HLA class II region Hum. Mol. Genet. 2014
53. J. Kira Multiple sclerosis in the Japanese population Lancet Neurol. 2 2003 117 127
54. A. Wennerström, E. Vlachopoulou, L.E. Lahtela, R. Paakkanen, K.T. Eronen, M. Seppänen, and M.L. Lokki Diversity of extended HLA-DRB1 haplotypes in the Finnish population PLoS ONE 8 2013 e79690
55. X.M. Wu, C. Wang, K.N. Zhang, A.Y. Lin, J. Kira, G.Z. Hu, X.H. Qu, Y.Q. Xiong, W.F. Cao, and L.Y. Gong Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations Mult. Scler. 15 2009 1422 1430
56. T.W. Wu, C.C. Chu, H.W. Liao, S.K. Lin, T.Y. Ho, M. Lin, H.H. Lin, and L.Y. Wang HLA-DPB1 and anti-HBs titer kinetics in hepatitis B booster recipients who completed primary hepatitis B vaccination during infancy Genes Immun. 15 2014 47 53
57. S. Sawcer, G. Hellenthal, M. Pirinen, C.C. Spencer, N.A. Patsopoulos, L. Moutsianas, A. Dilthey, Z. Su, C. Freeman, S.E. Hunt International Multiple Sclerosis Genetics Consortium Wellcome Trust Case Control Consortium 2 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Nature 476 2011 214 219
58. J. Link, A.R. Lorentzen, I. Kockum, K. Duvefelt, B.A. Lie, E.G. Celius, H.F. Harbo, J. Hillert, and B. Brynedal Two HLA class I genes independently associated with multiple sclerosis J. Neuroimmunol. 226 2010 172 176
59. S. Nejentsev, J.M. Howson, N.M. Walker, J. Szeszko, S.F. Field, H.E. Stevens, P. Reynolds, M. Hardy, E. King, J. Masters Wellcome Trust Case Control Consortium Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A Nature 450 2007 887 892
60. J.P. Higgins, and S.G. Thompson Quantifying heterogeneity in a meta-analysis Stat. Med. 21 2002 1539 1558