Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 12, 2016, Pages 3323-3328

  Flach, Anne Christine ^a   Litke, Tanja ^a   Strauss, Judith ^a   Haberl, Michael ^a   Cordero Gómez, César ^a   Reindl, Markus ^b   Saiz, Albert ^c   Fehling, Hans Jörg ^d   Wienands, Jürgen ^a   Odoardi, Francesca ^a   Lühder, Fred ^a   Flügel, Alexander ^a,e  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c UNIVERSITY OF BARCELONA   (Spain)

^d UNIVERSITY OF ULM   (Germany)

^e MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Autoantibodies; Autoimmunity; B cells; EAE; Multiple sclerosis

Indexed keywords

AUTOANTIBODY; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OVALBUMIN; X BOX BINDING PROTEIN 1;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EFFECTOR CELL; IMMUNOCOMPETENT CELL; LASER MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PATHOLOGY; T LYMPHOCYTE;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES;

EID: 84962316006     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519608113     Document Type: Article

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