-
1
-
-
84885454468
-
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
-
Guilliams, M. et al. Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF. J. Exp. Med. 210, 1977-1992 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1977-1992
-
-
Guilliams, M.1
-
2
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi, O. & Akira, S. Pattern recognition receptors and inflammation. Cell 140, 805-820 (2010).
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
3
-
-
84919416051
-
Role of alveolar macrophages in chronic obstructive pulmonary disease
-
Vlahos, R. & Bozinovski, S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front. Immunol. 5, 435 (2014).
-
(2014)
Front. Immunol.
, vol.5
, pp. 435
-
-
Vlahos, R.1
Bozinovski, S.2
-
4
-
-
80355131976
-
Protective and pathogenic functions of macrophage subsets
-
Murray, P.J. & Wynn, T.A. Protective and pathogenic functions of macrophage subsets. Nat. Rev. Immunol. 11, 723-737 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 723-737
-
-
Murray, P.J.1
Wynn, T.A.2
-
5
-
-
84925283050
-
The development and function of lung-resident macrophages and dendritic cells
-
Kopf, M., Schneider, C. & Nobs, S.P. The development and function of lung-resident macrophages and dendritic cells. Nat. Immunol. 16, 36-44 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 36-44
-
-
Kopf, M.1
Schneider, C.2
Nobs, S.P.3
-
6
-
-
84893652705
-
Alveolar macrophages: Plasticity in a tissue-specific context
-
Hussell, T. & Bell, T.J. Alveolar macrophages: plasticity in a tissue-specific context. Nat. Rev. Immunol. 14, 81-93 (2014).
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 81-93
-
-
Hussell, T.1
Bell, T.J.2
-
7
-
-
84896715280
-
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
-
Westphalen, K. et al. Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506, 503-506 (2014).
-
(2014)
Nature
, vol.506
, pp. 503-506
-
-
Westphalen, K.1
-
8
-
-
33744722811
-
Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa
-
Ballinger, M.N. et al. Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa. Am. J. Respir. Cell Mol. Biol. 34, 766-774 (2006).
-
(2006)
Am. J. Respir. Cell Mol. Biol.
, vol.34
, pp. 766-774
-
-
Ballinger, M.N.1
-
9
-
-
20044379240
-
Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection
-
Gonzalez-Juarrero, M. et al. Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. J. Leukoc. Biol. 77, 914-922 (2005).
-
(2005)
J. Leukoc. Biol.
, vol.77
, pp. 914-922
-
-
Gonzalez-Juarrero, M.1
-
10
-
-
0034161743
-
Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice
-
Paine, R. III et al. Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice. J. Immunol. 164, 2602-2609 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 2602-2609
-
-
Paine, R.1
-
11
-
-
0033557298
-
GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
-
LeVine, A.M., Reed, J.A., Kurak, K.E., Cianciolo, E. & Whitsett, J.A. GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection. J. Clin. Invest. 103, 563-569 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 563-569
-
-
LeVine, A.M.1
Reed, J.A.2
Kurak, K.E.3
Cianciolo, E.4
Whitsett, J.A.5
-
12
-
-
84904891152
-
Deaths: Final data for 2010
-
Murphy, S.L., Xu, J. & Kochanek, K.D. Deaths: final data for 2010. Natl. Vital Stat. Rep. 61, 1-117 (2013).
-
(2013)
Natl. Vital Stat. Rep.
, vol.61
, pp. 1-117
-
-
Murphy, S.L.1
Xu, J.2
Kochanek, K.D.3
-
13
-
-
84901379724
-
Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection
-
Schneider, C. et al. Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection. PLoS Pathog. 10, e1004053 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1004053
-
-
Schneider, C.1
-
14
-
-
80051553380
-
GM-CSF in the lung protects against lethal influenza infection
-
Huang, F.F. et al. GM-CSF in the lung protects against lethal influenza infection. Am. J. Respir. Crit. Care Med. 184, 259-268 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.184
, pp. 259-268
-
-
Huang, F.F.1
-
15
-
-
79959824589
-
Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-? Induction
-
van Riel, D. et al. Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-? induction. PLoS Pathog. 7, e1002099 (2011).
-
(2011)
PLoS Pathog.
, vol.7
, pp. e1002099
-
-
Van Riel, D.1
-
16
-
-
34548028711
-
Alveolar macrophages are the primary interferon-? Producer in pulmonary infection with RNA viruses
-
Kumagai, Y. et al. Alveolar macrophages are the primary interferon-? producer in pulmonary infection with RNA viruses. Immunity 27, 240-252 (2007).
-
(2007)
Immunity
, vol.27
, pp. 240-252
-
-
Kumagai, Y.1
-
17
-
-
79952237074
-
Type i interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice
-
Seo, S.U. et al. Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog. 7, e1001304 (2011).
-
(2011)
PLoS Pathog.
, vol.7
, pp. e1001304
-
-
Seo, S.U.1
-
18
-
-
84862777209
-
IFITM3 restricts the morbidity and mortality associated with influenza
-
Everitt, A.R. et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484, 519-523 (2012).
-
(2012)
Nature
, vol.484
, pp. 519-523
-
-
Everitt, A.R.1
-
19
-
-
84866930893
-
Ifitm3 limits the severity of acute influenza in mice
-
Bailey, C.C., Huang, I.C., Kam, C. & Farzan, M. Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog. 8, e1002909 (2012).
-
(2012)
PLoS Pathog.
, vol.8
, pp. e1002909
-
-
Bailey, C.C.1
Huang, I.C.2
Kam, C.3
Farzan, M.4
-
20
-
-
63149158618
-
Antiviral immune responses: Triggers of or triggered by autoimmunity?
-
Münz, C., Lünemann, J.D., Getts, M.T. & Miller, S.D. Antiviral immune responses: triggers of or triggered by autoimmunity? Nat. Rev. Immunol. 9, 246-258 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 246-258
-
-
Münz, C.1
Lünemann, J.D.2
Getts, M.T.3
Miller, S.D.4
-
21
-
-
44649183243
-
Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
-
1378
-
Fitzpatrick, A.M., Holguin, F., Teague, W.G. & Brown, L.A. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J. Allergy Clin. Immunol. 121, 1372-1378, 1378 (2008).
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
, pp. 1372-1378
-
-
Fitzpatrick, A.M.1
Holguin, F.2
Teague, W.G.3
Brown, L.A.4
-
22
-
-
0021263831
-
Alveolar macrophage dysfunction in malignant lung tumours
-
Lemarie, E. et al. Alveolar macrophage dysfunction in malignant lung tumours. Thorax 39, 448-452 (1984).
-
(1984)
Thorax
, vol.39
, pp. 448-452
-
-
Lemarie, E.1
-
23
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew, F.Y., Xu, D., Brint, E.K. & O'Neill, L.A. Negative regulation of toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5, 446-458 (2005).
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.4
-
24
-
-
84655176306
-
The role of ubiquitylation in immune defence and pathogen evasion
-
Jiang, X. & Chen, Z.J. The role of ubiquitylation in immune defence and pathogen evasion. Nat. Rev. Immunol. 12, 35-48 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.12
, pp. 35-48
-
-
Jiang, X.1
Chen, Z.J.2
-
25
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type i interferon induction
-
Kawai, T. et al. IPS-1, an adaptor triggering RIG-I-and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981-988 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 981-988
-
-
Kawai, T.1
-
26
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-?B and IRF 3
-
Seth, R.B., Sun, L., Ea, C.K. & Chen, Z.J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-?B and IRF 3. Cell 122, 669-682 (2005).
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
27
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-? Signaling
-
Xu, L.G. et al. VISA is an adapter protein required for virus-triggered IFN-? signaling. Mol. Cell 19, 727-740 (2005).
-
(2005)
Mol. Cell
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
-
28
-
-
58049202272
-
Innate immunity to virus infection
-
Takeuchi, O. & Akira, S. Innate immunity to virus infection. Immunol. Rev. 227, 75-86 (2009).
-
(2009)
Immunol. Rev.
, vol.227
, pp. 75-86
-
-
Takeuchi, O.1
Akira, S.2
-
29
-
-
79952455073
-
Detection and characterization of the in vitro e3 ligase activity of the human MID1 protein
-
Han, X., Du, H. & Massiah, M.A. Detection and characterization of the in vitro e3 ligase activity of the human MID1 protein. J. Mol. Biol. 407, 505-520 (2011).
-
(2011)
J. Mol. Biol.
, vol.407
, pp. 505-520
-
-
Han, X.1
Du, H.2
Massiah, M.A.3
-
30
-
-
84858116985
-
Peli: A family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance
-
Jin, W., Chang, M. & Sun, S.C. Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance. Cell. Mol. Immunol. 9, 113-122 (2012).
-
(2012)
Cell. Mol. Immunol.
, vol.9
, pp. 113-122
-
-
Jin, W.1
Chang, M.2
Sun, S.C.3
-
31
-
-
70349472923
-
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
-
Chang, M., Jin, W. & Sun, S.C. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10, 1089-1095 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1089-1095
-
-
Chang, M.1
Jin, W.2
Sun, S.C.3
-
32
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
33
-
-
33344476398
-
CATERPILLERs, pyrin and hereditary immunological disorders
-
Ting, J.P., Kastner, D.L. & Hoffman, H.M. CATERPILLERs, pyrin and hereditary immunological disorders. Nat. Rev. Immunol. 6, 183-195 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 183-195
-
-
Ting, J.P.1
Kastner, D.L.2
Hoffman, H.M.3
-
34
-
-
37849014248
-
Toll-like receptors and immune regulation: Implications for cancer therapy
-
Wang, R.F., Miyahara, Y. & Wang, H.Y. Toll-like receptors and immune regulation: implications for cancer therapy. Oncogene 27, 181-189 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 181-189
-
-
Wang, R.F.1
Miyahara, Y.2
Wang, H.Y.3
-
35
-
-
79951671973
-
New developments in the induction and antiviral effectors of type i interferon
-
Liu, S.Y., Sanchez, D.J. & Cheng, G. New developments in the induction and antiviral effectors of type I interferon. Curr. Opin. Immunol. 23, 57-64 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 57-64
-
-
Liu, S.Y.1
Sanchez, D.J.2
Cheng, G.3
-
36
-
-
46249115827
-
Interferon-inducible antiviral effectors
-
Sadler, A.J. & Williams, B.R. Interferon-inducible antiviral effectors. Nat. Rev. Immunol. 8, 559-568 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 559-568
-
-
Sadler, A.J.1
Williams, B.R.2
-
37
-
-
0035061538
-
IRF family of transcription factors as regulators of host defense
-
Taniguchi, T., Ogasawara, K., Takaoka, A. & Tanaka, N. IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol. 19, 623-655 (2001).
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 623-655
-
-
Taniguchi, T.1
Ogasawara, K.2
Takaoka, A.3
Tanaka, N.4
-
38
-
-
33750433585
-
Manipulation of the nuclear factor-?B pathway and the innate immune response by viruses
-
Hiscott, J., Nguyen, T.L., Arguello, M., Nakhaei, P. & Paz, S. Manipulation of the nuclear factor-?B pathway and the innate immune response by viruses. Oncogene 25, 6844-6867 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 6844-6867
-
-
Hiscott, J.1
Nguyen, T.L.2
Arguello, M.3
Nakhaei, P.4
Paz, S.5
-
39
-
-
0038363463
-
Triggering the interferon antiviral response through an IKK-related pathway
-
Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148-1151 (2003).
-
(2003)
Science
, vol.300
, pp. 1148-1151
-
-
Sharma, S.1
-
40
-
-
0038393016
-
IKK? and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald, K.A. et al. IKK? and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
-
41
-
-
34249058119
-
The NEMO adaptor bridges the nuclear factor-?B and interferon regulatory factor signaling pathways
-
Zhao, T. et al. The NEMO adaptor bridges the nuclear factor-?B and interferon regulatory factor signaling pathways. Nat. Immunol. 8, 592-600 (2007).
-
(2007)
Nat. Immunol.
, vol.8
, pp. 592-600
-
-
Zhao, T.1
-
42
-
-
84934963416
-
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin
-
Masuda, Y. et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat. Commun. 6, 7299 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7299
-
-
Masuda, Y.1
-
43
-
-
84955282032
-
ATDC/TRIM29 drives invasive bladder cancer formation through miRNA-mediated and epigenetic mechanisms
-
Palmbos, P.L. et al. ATDC/TRIM29 drives invasive bladder cancer formation through miRNA-mediated and epigenetic mechanisms. Cancer Res. 75, 5155-5166 (2015).
-
(2015)
Cancer Res.
, vol.75
, pp. 5155-5166
-
-
Palmbos, P.L.1
-
44
-
-
0345826149
-
Bcl10 activates the NF-?B pathway through ubiquitination of NEMO
-
Zhou, H. et al. Bcl10 activates the NF-?B pathway through ubiquitination of NEMO. Nature 427, 167-171 (2004).
-
(2004)
Nature
, vol.427
, pp. 167-171
-
-
Zhou, H.1
-
45
-
-
2342629277
-
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
-
Sun, L., Deng, L., Ea, C.K., Xia, Z.P. & Chen, Z.J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14, 289-301 (2004).
-
(2004)
Mol. Cell
, vol.14
, pp. 289-301
-
-
Sun, L.1
Deng, L.2
Ea, C.K.3
Xia, Z.P.4
Chen, Z.J.5
-
46
-
-
84865119303
-
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex
-
Belgnaoui, S.M. et al. Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe 12, 211-222 (2012).
-
(2012)
Cell Host Microbe
, vol.12
, pp. 211-222
-
-
Belgnaoui, S.M.1
-
47
-
-
77957677615
-
Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense
-
Arimoto, K. et al. Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc. Natl. Acad. Sci. USA 107, 15856-15861 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15856-15861
-
-
Arimoto, K.1
-
48
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov, R. Recognition of microorganisms and activation of the immune response. Nature 449, 819-826 (2007).
-
(2007)
Nature
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
50
-
-
84876685141
-
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
-
Lupfer, C. et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat. Immunol. 14, 480-488 (2013).
-
(2013)
Nat. Immunol.
, vol.14
, pp. 480-488
-
-
Lupfer, C.1
|