-
1
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson, S. P. & Bartek, J. The DNA-damage response in human biology and disease. Nature 461, 1071-1078 (2009).
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
2
-
-
78649336706
-
The DNA damage response: Making it safe to play with knives
-
Ciccia, A. & Elledge, S. J. The DNA damage response: making it safe to play with knives. Mol. Cell 40, 179-204 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 179-204
-
-
Ciccia, A.1
Elledge, S.J.2
-
3
-
-
78649446475
-
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
-
Dobbs, T. A., Tainer, J. A. & Lees-Miller, S. P. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair 9, 1307-1314 (2010).
-
(2010)
DNA Repair
, vol.9
, pp. 1307-1314
-
-
Dobbs, T.A.1
Tainer, J.A.2
Lees-Miller, S.P.3
-
4
-
-
78649445307
-
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
-
Williams, G. J., Lees-Miller, S. P. & Tainer, J. A. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair 9, 1299-1306 (2010).
-
(2010)
DNA Repair
, vol.9
, pp. 1299-1306
-
-
Williams, G.J.1
Lees-Miller, S.P.2
Tainer, J.A.3
-
5
-
-
65149084552
-
Crosstalk between histone modifications during the DNA damage response
-
van Attikum, H. & Gasser, S. M. Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol. 19, 207-217 (2009).
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 207-217
-
-
Van Attikum, H.1
Gasser, S.M.2
-
6
-
-
38049115657
-
The mechanism of human nonhomologous DNA end joining
-
Lieber, M. R. The mechanism of human nonhomologous DNA end joining. J. Biol. Chem. 283, 1-5 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1-5
-
-
Lieber, M.R.1
-
7
-
-
50649100744
-
Mechanism of eukaryotic homologous recombination
-
San Filippo, J., Sung, P. & Klein, H. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77, 229-257 (2008).
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 229-257
-
-
San Filippo, J.1
Sung, P.2
Klein, H.3
-
8
-
-
77957948991
-
DNA mismatch repair and the DNA damage response to ionizing radiation: Making sense of apparently conflicting data
-
Martin, L. M. et al. DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data. Cancer Treat. Rev. 36, 518-527 (2010).
-
(2010)
Cancer Treat. Rev.
, vol.36
, pp. 518-527
-
-
Martin, L.M.1
-
9
-
-
0034655991
-
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
-
Wang, Y. et al. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14, 927-939 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 927-939
-
-
Wang, Y.1
-
10
-
-
80053555789
-
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
-
Lukas, J., Lukas, C. & Bartek, J. More than just a focus: the chromatin response to DNA damage and its role in genome integrity maintenance. Nat. Cell Biol. 13, 1161-1169 (2011).
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1161-1169
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
11
-
-
84878918708
-
The chromatin response to DNA breaks: Leaving a mark on genome integrity
-
Smeenk, G. & van Attikum, H. The chromatin response to DNA breaks: leaving a mark on genome integrity. Annu. Rev. Biochem. 82, 55-80 (2013).
-
(2013)
Annu. Rev. Biochem.
, vol.82
, pp. 55-80
-
-
Smeenk, G.1
Van Attikum, H.2
-
12
-
-
84879888213
-
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
-
Fradet-Turcotte, A. et al. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature 499, 50-54 (2013).
-
(2013)
Nature
, vol.499
, pp. 50-54
-
-
Fradet-Turcotte, A.1
-
13
-
-
84875224166
-
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination
-
Tang, J. et al. Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat. Struct. Mol. Biol. 20, 317-325 (2013).
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 317-325
-
-
Tang, J.1
-
14
-
-
79952256559
-
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
-
Fnu, S. et al. Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining. Proc. Natl Acad. Sci. USA 108, 540-545 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 540-545
-
-
Fnu, S.1
-
15
-
-
84897990643
-
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
-
Aymard, F. et al. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat. Struct. Mol. Biol. 21, 366-374 (2014).
-
(2014)
Nat. Struct. Mol. Biol.
, vol.21
, pp. 366-374
-
-
Aymard, F.1
-
16
-
-
84876943255
-
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha
-
Li, F. et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha. Cell 153, 590-600 (2013).
-
(2013)
Cell
, vol.153
, pp. 590-600
-
-
Li, F.1
-
17
-
-
84903451450
-
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
-
Pfister, S. X. et al. SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep. 7, 2006-2018 (2014).
-
(2014)
Cell Rep.
, vol.7
, pp. 2006-2018
-
-
Pfister, S.X.1
-
18
-
-
0029057336
-
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
-
Savitsky, K. et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753 (1995).
-
(1995)
Science
, vol.268
, pp. 1749-1753
-
-
Savitsky, K.1
-
19
-
-
0026636702
-
Cloning of a candidate gene for ataxia-telangiectasia group D
-
Kapp, L. N. et al. Cloning of a candidate gene for ataxia-telangiectasia group D. Am. J. Hum. Genet. 51, 45-54 (1992).
-
(1992)
Am. J. Hum. Genet.
, vol.51
, pp. 45-54
-
-
Kapp, L.N.1
-
20
-
-
80054848955
-
TRIM proteins and cancer
-
Hatakeyama, S. TRIM proteins and cancer. Nat. Rev. Cancer 11, 792-804 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 792-804
-
-
Hatakeyama, S.1
-
21
-
-
77953416244
-
The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions
-
Yuan, Z. et al. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol. Cell. Biol. 30, 3004-3015 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3004-3015
-
-
Yuan, Z.1
-
22
-
-
84896497591
-
ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells
-
Wang, L. et al. ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells. Cancer Res. 74, 1778-1788 (2014).
-
(2014)
Cancer Res.
, vol.74
, pp. 1778-1788
-
-
Wang, L.1
-
23
-
-
0029112667
-
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor
-
Brzoska, P. M. et al. The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor. Proc. Natl Acad. Sci. USA 92, 7824-7828 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7824-7828
-
-
Brzoska, P.M.1
-
24
-
-
79955658113
-
TRIM29 negatively regulates p53 via inhibition of Tip60
-
Sho, T. et al. TRIM29 negatively regulates p53 via inhibition of Tip60. Biochim. Biophys. Acta 1813, 1245-1253 (2011).
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1245-1253
-
-
Sho, T.1
-
25
-
-
60649114313
-
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization
-
Wang, L. et al. Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization. Cancer Cell 15, 207-219 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 207-219
-
-
Wang, L.1
-
26
-
-
84904068372
-
TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer
-
Kanno, Y. et al. TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer. Acta Histochem. 116, 708-712 (2014).
-
(2014)
Acta Histochem.
, vol.116
, pp. 708-712
-
-
Kanno, Y.1
-
27
-
-
17744371839
-
The tripartite motif family identifies cell compartments
-
Reymond, A. et al. The tripartite motif family identifies cell compartments. EMBO J. 20, 2140-2151 (2001).
-
(2001)
EMBO J.
, vol.20
, pp. 2140-2151
-
-
Reymond, A.1
-
28
-
-
47249100637
-
A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin
-
Aygun, O., Svejstrup, J. & Liu, Y. A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Proc. Natl Acad. Sci. USA 105, 8580-8584 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8580-8584
-
-
Aygun, O.1
Svejstrup, J.2
Liu, Y.3
-
29
-
-
0037168586
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
-
Strausberg, R. L. et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl Acad. Sci. USA 99, 16899-16903 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16899-16903
-
-
Strausberg, R.L.1
-
30
-
-
79959939884
-
Human mediator subunit MED26 functions as a docking site for transcription elongation factors
-
Takahashi, H. et al. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. Cell 146, 92-104 (2011).
-
(2011)
Cell
, vol.146
, pp. 92-104
-
-
Takahashi, H.1
-
31
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168 (2003).
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
32
-
-
77952563068
-
Condensin and cohesin complexity: The expanding repertoire of functions
-
Wood, A. J., Severson, A. F. & Meyer, B. J. Condensin and cohesin complexity: the expanding repertoire of functions. Nat. Rev. Genet. 11, 391-404 (2010).
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 391-404
-
-
Wood, A.J.1
Severson, A.F.2
Meyer, B.J.3
-
33
-
-
34248572591
-
Structure of the human MutSalpha DNA lesion recognition complex
-
Warren, J. J. et al. Structure of the human MutSalpha DNA lesion recognition complex. Mol. Cell 26, 579-592 (2007).
-
(2007)
Mol. Cell
, vol.26
, pp. 579-592
-
-
Warren, J.J.1
-
34
-
-
38049125557
-
Mechanisms and functions of DNA mismatch repair
-
Li, G. M. Mechanisms and functions of DNA mismatch repair. Cell Res. 18, 85-98 (2008).
-
(2008)
Cell Res.
, vol.18
, pp. 85-98
-
-
Li, G.M.1
-
35
-
-
0001607723
-
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold
-
Walker, J. E., Saraste, M., Runswick, M. J. & Gay, N. J. Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1, 945-951 (1982).
-
(1982)
EMBO J.
, vol.1
, pp. 945-951
-
-
Walker, J.E.1
Saraste, M.2
Runswick, M.J.3
Gay, N.J.4
-
36
-
-
0037412181
-
A conformational analysis of Walker motif A [GXXXXGKT (S)] in nucleotide-binding and other proteins
-
Ramakrishnan, C., Dani, V. S. & Ramasarma, T. A conformational analysis of Walker motif A [GXXXXGKT (S)] in nucleotide-binding and other proteins. Protein Eng. 15, 783-798 (2002).
-
(2002)
Protein Eng.
, vol.15
, pp. 783-798
-
-
Ramakrishnan, C.1
Dani, V.S.2
Ramasarma, T.3
-
37
-
-
0025048136
-
The P-loop-A common motif in ATP- and GTP-binding proteins
-
Saraste, M., Sibbald, P. R. & Wittinghofer, A. The P-loop-a common motif in ATP- and GTP-binding proteins. Trends Biochem. Sci. 15, 430-434 (1990).
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 430-434
-
-
Saraste, M.1
Sibbald, P.R.2
Wittinghofer, A.3
-
38
-
-
84902168468
-
Regulating the chromatin landscape: Structural and mechanistic perspectives
-
Bartholomew, B. Regulating the chromatin landscape: structural and mechanistic perspectives. Annu. Rev. Biochem. 83, 671-696 (2014).
-
(2014)
Annu. Rev. Biochem.
, vol.83
, pp. 671-696
-
-
Bartholomew, B.1
-
39
-
-
0037226473
-
The mismatch repair system is required for S-phase checkpoint activation
-
Brown, K. D. et al. The mismatch repair system is required for S-phase checkpoint activation. Nat. Genet. 33, 80-84 (2003).
-
(2003)
Nat. Genet.
, vol.33
, pp. 80-84
-
-
Brown, K.D.1
-
40
-
-
0038297562
-
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase
-
Franchitto, A. et al. The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. Oncogene 22, 2110-2120 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 2110-2120
-
-
Franchitto, A.1
-
41
-
-
84878944044
-
Readout of epigenetic modifications
-
Patel, D. J. & Wang, Z. Readout of epigenetic modifications. Annu. Rev. Biochem. 82, 81-118 (2013).
-
(2013)
Annu. Rev. Biochem.
, vol.82
, pp. 81-118
-
-
Patel, D.J.1
Wang, Z.2
-
42
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen, S. et al. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206 (2006).
-
(2006)
J. Cell Biol.
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
-
43
-
-
23744447715
-
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
-
Kim, J. S. et al. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 170, 341-347 (2005).
-
(2005)
J. Cell Biol.
, vol.170
, pp. 341-347
-
-
Kim, J.S.1
-
44
-
-
84863415403
-
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair
-
Polo, S. E. et al. Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair. Mol. Cell 45, 505-516 (2012).
-
(2012)
Mol. Cell
, vol.45
, pp. 505-516
-
-
Polo, S.E.1
-
45
-
-
84886259963
-
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
-
Altmeyer, M. et al. The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling. Mol. Cell 52, 206-220 (2013).
-
(2013)
Mol. Cell
, vol.52
, pp. 206-220
-
-
Altmeyer, M.1
-
46
-
-
84860325854
-
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
-
Beli, P. et al. Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol. Cell 46, 212-225 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 212-225
-
-
Beli, P.1
-
47
-
-
0024370460
-
A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection
-
Albritton, L. M., Tseng, L., Scadden, D. & Cunningham, J. M. A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection. Cell 57, 659-666 (1989).
-
(1989)
Cell
, vol.57
, pp. 659-666
-
-
Albritton, L.M.1
Tseng, L.2
Scadden, D.3
Cunningham, J.M.4
-
48
-
-
0034046944
-
Plat-E: An efficient and stable system for transient packaging of retroviruses
-
Morita, S., Kojima, T. & Kitamura, T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066 (2000).
-
(2000)
Gene Ther.
, vol.7
, pp. 1063-1066
-
-
Morita, S.1
Kojima, T.2
Kitamura, T.3
-
49
-
-
0021100690
-
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
-
Dignam, J. D., Lebovitz, R. M. & Roeder, R. G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489 (1983).
-
(1983)
Nucleic Acids Res.
, vol.11
, pp. 1475-1489
-
-
Dignam, J.D.1
Lebovitz, R.M.2
Roeder, R.G.3
|