Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

Nature Medicine

Volumn 22, Issue 11, 2016, Pages 1285-1293

  Liang, Jiurong ^a   Zhang, Yanli ^a,c   Xie, Ting ^a   Liu, Ningshan ^a   Chen, Huaiyong ^b,d,e   Geng, Yan ^a   Kurkciyan, Adrianne ^a   Mena, Jessica Monterrosa ^a   Stripp, Barry R ^a   Jiang, Dianhua ^a   Noble, Paul W ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TSINGHUA UNIVERSITY   (China)

^d Tianjin Haihe Hospital   (China)

^e Tianjin Respiratory Disease Research Institute   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD24 ANTIGEN; CXCL2 CHEMOKINE; HYALURONIC ACID; INTERLEUKIN 6; STAT3 PROTEIN; SURFACTANT PROTEIN C; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; ANTINEOPLASTIC ANTIBIOTIC; BLEOMYCIN; GLUCURONOSYLTRANSFERASE; HAS2 PROTEIN, MOUSE; HYDROXYPROLINE; INTERLEUKIN-6, MOUSE; TLR4 PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIFFERENTIATION; CELL SURFACE; COLONY FORMATION; COLONY FORMING UNIT; CONTROLLED STUDY; FLOW CYTOMETRY; INFLAMMATORY CELL; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM CELL; LUNG DEVELOPMENT; LUNG FIBROBLAST; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL SELF-RENEWAL; ANIMAL; CELL LINE; CELL PROLIFERATION; CELL SELF-RENEWAL; CHEMICALLY INDUCED; CYTOPLASM; FIBROSING ALVEOLITIS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG INJURY; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; STEM CELL;

ALVEOLAR EPITHELIAL CELLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL LINE; CELL PROLIFERATION; CELL SELF RENEWAL; FLOW CYTOMETRY; GLUCURONOSYLTRANSFERASE; HUMANS; HYALURONIC ACID; HYDROXYPROLINE; IDIOPATHIC PULMONARY FIBROSIS; IMMUNITY, INNATE; INTERLEUKIN-6; LUNG INJURY; MICE; MICE, KNOCKOUT; ORGANOIDS; PULMONARY FIBROSIS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; REAL-TIME POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; STEM CELLS; TOLL-LIKE RECEPTOR 4;

EID: 84989814118     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4192     Document Type: Article

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