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Volumn 111, Issue 35, 2014, Pages

IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells

Author keywords

Cell fate; Epithelial repair; Mucociliary epithelium

Indexed keywords

CELL FATE; EPITHELIAL REPAIR; MUCOCILIARY EPITHELIUM;

EID: 84907228030     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409781111     Document Type: Article
Times cited : (210)

References (51)
  • 3
    • 79957797173 scopus 로고    scopus 로고
    • Notch-dependent differentiation of adult airway basal stem cells
    • Rock JR, et al. (2011) Notch-dependent differentiation of adult airway basal stem cells. Cell Stem Cell 8(6):639-648.
    • (2011) Cell Stem Cell , vol.8 , Issue.6 , pp. 639-648
    • Rock, J.R.1
  • 4
    • 69149106207 scopus 로고    scopus 로고
    • Basal cells as stem cells of the mouse trachea and human airway epithelium
    • Rock JR, et al. (2009) Basal cells as stem cells of the mouse trachea and human airway epithelium. Proc Natl Acad Sci USA 106(31):12771-12775.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.31 , pp. 12771-12775
    • Rock, J.R.1
  • 5
    • 77955435635 scopus 로고    scopus 로고
    • New pharmacotherapy for airway mucus hypersecretion in asthma and COPD: Targeting intracellular signaling pathways
    • Lai H, Rogers DF (2010) New pharmacotherapy for airway mucus hypersecretion in asthma and COPD: Targeting intracellular signaling pathways. J Aerosol Med Pulm Drug Deliv 23(4):219-231.
    • (2010) J Aerosol Med Pulm Drug Deliv , vol.23 , Issue.4 , pp. 219-231
    • Lai, H.1    Rogers, D.F.2
  • 6
    • 33751200667 scopus 로고    scopus 로고
    • Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease
    • Randell SH (2006) Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 3(8):718- 725.
    • (2006) Proc Am Thorac Soc , vol.3 , Issue.8 , pp. 718-725
    • Randell, S.H.1
  • 7
    • 68549121214 scopus 로고    scopus 로고
    • Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
    • Guseh JS, et al. (2009) Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136(10):1751-1759.
    • (2009) Development , vol.136 , Issue.10 , pp. 1751-1759
    • Guseh, J.S.1
  • 8
    • 69549088763 scopus 로고    scopus 로고
    • Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
    • Tsao P-N, et al. (2009) Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development 136(13):2297-2307.
    • (2009) Development , vol.136 , Issue.13 , pp. 2297-2307
    • Tsao, P.-N.1
  • 9
    • 73849134811 scopus 로고    scopus 로고
    • Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
    • Morimoto M, et al. (2010) Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci 123(Pt 2):213-224.
    • (2010) J Cell Sci , vol.123 , Issue.PART 2 , pp. 213-224
    • Morimoto, M.1
  • 10
    • 79957895825 scopus 로고    scopus 로고
    • Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway
    • Marcet B, et al. (2011) Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway. Nat Cell Biol 13(6):693-699.
    • (2011) Nat Cell Biol , vol.13 , Issue.6 , pp. 693-699
    • Marcet, B.1
  • 11
    • 84868537980 scopus 로고    scopus 로고
    • Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells
    • Morimoto M, Nishinakamura R, Saga Y, Kopan R (2012) Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells. Development 139(23):4365-4373.
    • (2012) Development , vol.139 , Issue.23 , pp. 4365-4373
    • Morimoto, M.1    Nishinakamura, R.2    Saga, Y.3    Kopan, R.4
  • 12
    • 84903788691 scopus 로고    scopus 로고
    • Multicilin drives centriole biogenesis via E2f proteins
    • Ma L, Quigley I, Omran H, Kintner C (2014) Multicilin drives centriole biogenesis via E2f proteins. Genes Dev 28(13):1461-1471.
    • (2014) Genes Dev , vol.28 , Issue.13 , pp. 1461-1471
    • Ma, L.1    Quigley, I.2    Omran, H.3    Kintner, C.4
  • 13
    • 84856460296 scopus 로고    scopus 로고
    • Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation
    • Stubbs JL, Vladar EK, Axelrod JD, Kintner C (2012) Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol 14(2): 140-147.
    • (2012) Nat Cell Biol , vol.14 , Issue.2 , pp. 140-147
    • Stubbs, J.L.1    Vladar, E.K.2    Axelrod, J.D.3    Kintner, C.4
  • 14
    • 84884930913 scopus 로고    scopus 로고
    • Myb promotes centriole amplification and later steps of the multiciliogenesis program
    • Tan FE, et al. (2013) Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development 140(20):4277-4286.
    • (2013) Development , vol.140 , Issue.20 , pp. 4277-4286
    • Tan, F.E.1
  • 15
    • 84901949738 scopus 로고    scopus 로고
    • miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110
    • Song R, et al. (2014) miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature 510(7503):115-120.
    • (2014) Nature , vol.510 , Issue.7503 , pp. 115-120
    • Song, R.1
  • 16
    • 84904341198 scopus 로고    scopus 로고
    • Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis
    • Wu J, et al. (2014) Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci USA 111(28):E2851-E2857.
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.28
    • Wu, J.1
  • 17
    • 84869758362 scopus 로고    scopus 로고
    • Interleukin-6 - A key regulator of colorectal cancer development
    • Waldner MJ, Foersch S, Neurath MF (2012) Interleukin-6 - A key regulator of colorectal cancer development. Int J Biol Sci 8(9):1248-1253.
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1248-1253
    • Waldner, M.J.1    Foersch, S.2    Neurath, M.F.3
  • 20
    • 0034038544 scopus 로고    scopus 로고
    • Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung
    • Kuhn C, 3rd, et al. (2000) Airway hyperresponsiveness and airway obstruction in transgenic mice. Morphologic correlates in mice overexpressing interleukin (IL)-11 and IL-6 in the lung. Am J Respir Cell Mol Biol 22(3):289-295.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , Issue.3 , pp. 289-295
    • Kuhn III, C.1
  • 21
    • 77956538031 scopus 로고    scopus 로고
    • Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling
    • Rock JR, Randell SH, Hogan BL (2010) Airway basal stem cells: A perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech 3(9-10):545-556.
    • (2010) Dis Model Mech , vol.3 , Issue.9-10 , pp. 545-556
    • Rock, J.R.1    Randell, S.H.2    Hogan, B.L.3
  • 22
    • 84869834766 scopus 로고    scopus 로고
    • Role of IL-6 in asthma and other inflammatory pulmonary diseases
    • Rincon M, Irvin CG (2012) Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci 8(9):1281-1290.
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1281-1290
    • Rincon, M.1    Irvin, C.G.2
  • 23
    • 0032530312 scopus 로고    scopus 로고
    • Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry
    • Chen J, Knowles HJ, Hebert JL, Hackett BP (1998) Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry. J Clin Invest 102(6):1077-1082. (Pubitemid 28436267)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.6 , pp. 1077-1082
    • Chen, J.1    Knowles, H.J.2    Hebert, J.L.3    Hackett, B.P.4
  • 25
    • 56749163207 scopus 로고    scopus 로고
    • Foxj1 transcription factors are master regulators of the motile ciliogenic program
    • Yu X, Ng CP, Habacher H, Roy S (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nat Genet 40(12):1445-1453.
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1445-1453
    • Yu, X.1    Ng, C.P.2    Habacher, H.3    Roy, S.4
  • 26
    • 0142244084 scopus 로고    scopus 로고
    • Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter
    • DOI 10.1016/S1525-0016(03)00221-1
    • Ostrowski LE, Hutchins JR, Zakel K, O'Neal WK (2003) Targeting expression of a transgene to the airway surface epithelium using a ciliated cell-specific promoter. Mole Ther 8(4):637-645. (Pubitemid 37321693)
    • (2003) Molecular Therapy , vol.8 , Issue.4 , pp. 637-645
    • Ostrowski, L.E.1    Hutchins, J.R.2    Zakel, K.3    O'Neal, W.K.4
  • 27
    • 80053939641 scopus 로고    scopus 로고
    • Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways
    • Takakura A, et al. (2011) Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet 20(21):4143-4154.
    • (2011) Hum Mol Genet , vol.20 , Issue.21 , pp. 4143-4154
    • Takakura, A.1
  • 29
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell JE, Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82(2):241-250.
    • (1995) Cell , vol.82 , Issue.2 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell Jr., J.E.3
  • 31
    • 84878135304 scopus 로고    scopus 로고
    • Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways
    • Zhang S, Loch AJ, Radtke F, Egan SE, Xu K (2013) Jagged1 is the major regulator of Notch-dependent cell fate in proximal airways. Dev Dynamics 242(6):678-686.
    • (2013) Dev Dynamics , vol.242 , Issue.6 , pp. 678-686
    • Zhang, S.1    Loch, A.J.2    Radtke, F.3    Egan, S.E.4    Xu, K.5
  • 34
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine Signaling Modules in Inflammatory Responses
    • DOI 10.1016/j.immuni.2008.03.002, PII S1074761308001179
    • O' Shea JJ, Murray PJ (2008) Cytokine signaling modules in inflammatory responses. Immunity 28(4):477-487. (Pubitemid 351467044)
    • (2008) Immunity , vol.28 , Issue.4 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 35
    • 80051701140 scopus 로고    scopus 로고
    • CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing
    • Li Z, Burns AR, Miller SB, Smith CW (2011) CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing. FASEB J 25(8):2659-2668.
    • (2011) FASEB J , vol.25 , Issue.8 , pp. 2659-2668
    • Li, Z.1    Burns, A.R.2    Miller, S.B.3    Smith, C.W.4
  • 36
    • 0038583861 scopus 로고    scopus 로고
    • Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms
    • DOI 10.1128/MCB.23.11.4013-4025.2003
    • Hamilton TG, Klinghoffer RA, Corrin PD, Soriano P (2003) Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol 23(11):4013-4025. (Pubitemid 36597478)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.11 , pp. 4013-4025
    • Hamilton, T.G.1    Klinghoffer, R.A.2    Corrin, P.D.3    Soriano, P.4
  • 37
    • 82755187131 scopus 로고    scopus 로고
    • Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells
    • Neveu WA, et al. (2011) Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells. Am J Respir Cell Mol Biol 45(6):1133-1141.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , Issue.6 , pp. 1133-1141
    • Neveu, W.A.1
  • 38
    • 79955650634 scopus 로고    scopus 로고
    • The pro- and anti-inflammatory properties of the cytokine interleukin-6
    • Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S (2011) The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta 1813(5):878-888.
    • (2011) Biochim Biophys Acta , vol.1813 , Issue.5 , pp. 878-888
    • Scheller, J.1    Chalaris, A.2    Schmidt-Arras, D.3    Rose-John, S.4
  • 39
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang H, et al. (2009) Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137(7):1343-1355.
    • (2009) Cell , vol.137 , Issue.7 , pp. 1343-1355
    • Jiang, H.1
  • 40
    • 77950367306 scopus 로고    scopus 로고
    • Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells
    • Lin G, Xu N, Xi R (2010) Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol 2(1):37-49.
    • (2010) J Mol Cell Biol , vol.2 , Issue.1 , pp. 37-49
    • Lin, G.1    Xu, N.2    Xi, R.3
  • 41
    • 84863402487 scopus 로고    scopus 로고
    • Local signaling within stem cell niches: Insights from Drosophila
    • Resende LP, Jones DL (2012) Local signaling within stem cell niches: Insights from Drosophila. Curr Opin Cell Biol 24(2):225-231.
    • (2012) Curr Opin Cell Biol , vol.24 , Issue.2 , pp. 225-231
    • Resende, L.P.1    Jones, D.L.2
  • 42
    • 84896257145 scopus 로고    scopus 로고
    • Switching on cilia: Transcriptional networks regulating ciliogenesis
    • Choksi SP, Lauter G, Swoboda P, Roy S (2014) Switching on cilia: Transcriptional networks regulating ciliogenesis. Development 141(7):1427-1441.
    • (2014) Development , vol.141 , Issue.7 , pp. 1427-1441
    • Choksi, S.P.1    Lauter, G.2    Swoboda, P.3    Roy, S.4
  • 43
    • 0027284109 scopus 로고
    • Bronchial epithelial shedding in asthmatics and non-asthmatics
    • DOI 10.1016/0954-6111(93)90118-J
    • Montefort S, Roche WR, Holgate ST (1993) Bronchial epithelial shedding in asthmatics and non-asthmatics. Resp Med 87(Suppl B):9-11. (Pubitemid 23266361)
    • (1993) Respiratory Medicine , vol.87 , Issue.SUPPL. B , pp. 9-11
    • Montefort, S.1    Roche, W.R.2    Holgate, S.T.3
  • 44
    • 84864485029 scopus 로고    scopus 로고
    • The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma
    • Hawkins GA, et al. (2012) The IL6R variation Asp(358)Ala is a potential modifier of lung function in subjects with asthma. J Allergy Clin Immunol 130(2):510-515 e511.
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.2
    • Hawkins, G.A.1
  • 45
    • 80052721297 scopus 로고    scopus 로고
    • Identification of IL6R and chromosome 11q13.5 as risk loci for asthma
    • Australian Asthma Genetics Consortium
    • Ferreira MA, et al.; Australian Asthma Genetics Consortium (2011) Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet 378(9795):1006-1014.
    • (2011) Lancet , vol.378 , Issue.9795 , pp. 1006-1014
    • Ferreira, M.A.1
  • 47
    • 80855130470 scopus 로고    scopus 로고
    • Distinct stem cells contribute to mammary gland development and maintenance
    • Van Keymeulen A, et al. (2011) Distinct stem cells contribute to mammary gland development and maintenance. Nature 479(7372):189-193.
    • (2011) Nature , vol.479 , Issue.7372 , pp. 189-193
    • Van Keymeulen, A.1
  • 48
    • 3042856262 scopus 로고    scopus 로고
    • Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
    • Srinivas S, Watanabe T (2001) Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol 1:4.
    • (2001) BMC Dev Biol , vol.1 , pp. 4
    • Srinivas, S.1    Watanabe, T.2
  • 49
    • 84870599083 scopus 로고    scopus 로고
    • Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells
    • Suprynowicz FA, et al. (2012) Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells. Proc Natl Acad Sci USA 109(49):20035-20040.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.49 , pp. 20035-20040
    • Suprynowicz, F.A.1
  • 50
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663-676. (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 51
    • 0030744123 scopus 로고    scopus 로고
    • Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3
    • DOI 10.1093/nar/25.11.2062
    • Wen Z, Darnell JE, Jr (1997) Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res 25(11):2062-2067. (Pubitemid 27303439)
    • (1997) Nucleic Acids Research , vol.25 , Issue.11 , pp. 2062-2067
    • Wen, Z.1    Darnell Jr., J.E.2


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