Unsuspected effects of a lung-specific cre deleter mouse line

Genesis

Volumn 49, Issue 3, 2011, Pages 152-159

  Jeannotte, Lucie ^a   Aubin, Josée ^a   Bourque, Sylvie ^a   Lemieux, Margot ^a   Montaron, Séverine ^a   Provencher St Pierre, Anne ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Cre toxicity; Hoxa5 gene conditional mutagenesis; Lung development; Sftpc cre recombinase transgene

Indexed keywords

BETA GALACTOSIDASE; CRE RECOMBINASE; SURFACTANT PROTEIN C;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; GENE; GENE ACTIVATION; GENE DELETION; GENE FUNCTION; HOX GENE; HOXA5 GENE; LACZ GENE; LUNG ALVEOLUS EPITHELIUM; LUNG DEVELOPMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ROSA26 GENE;

ANIMALS; CELL LINE; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE TARGETING; GENES, REPORTER; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; INTEGRASES; LUNG; MICE; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; PHENOTYPE; PHOSPHOPROTEINS; RECOMBINATION, GENETIC;

MAMMALIA; MUS;

EID: 79953046147     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20720     Document Type: Article

References (22)

1. Abler LL, Mansour SL, Sun X. 2009. Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. Dev Dyn 238: 1999-2013.
2. Aubin J, Lemieux M, Tremblay M, Bérard J, Jeannotte L. 1997. Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects. Dev Biol 192: 432-445.
3. Eblaghie MC, Reedy M, Oliver T, Mishima Y, Hogan BLM. 2006. Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol 291: 67-82.
4. Giroux S, Charron J. 1998. Defective development of the embryonic liver in N-myc-deficient mice. Dev Biol 195: 16-28.
5. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. 2009. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development 136: 1751-1759.
6. Kinkead R, LeBlanc M, Gulemetova R, Lalancette-Hébert M, Lemieux M, Mandeville I, Jeannotte L. 2004. Respiratory adaptations to lung morphological defects in adult mice lacking Hoxa5 gene function. Pediatr Res 56: 553-562.
7. Koitabashi N, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA. 2009. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res 105: 12-15.
8. Larochelle C, Tremblay M, Bernier D, Aubin J, Jeannotte L. 1999. Multiple cis-acting regulatory regions are required for restricted spatio-temporal Hoxa5 gene expression. Dev Dyn 214: 127-140.
9. Mandeville I, Aubin J, LeBlanc M, Lalancette-Hébert M, Janelle MF, Tremblay GM, Jeannotte L. 2006. Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol 169: 1312-1327.
10. Matthaei KI. 2007. Genetically manipulated mice: A powerful tool with unsuspected caveats. J Physiol 582 (pt 2): 481-488.
11. Mura M, Binnie M, Han B, Li C, Andrade CF, Shiozaki A, Zhang Y, Ferrara N, Hwang D, Waddell TK, Keshavjee S, Liu M. 2010. Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability. Am J Pathol 176: 1725-1734.
12. Nagy A, Mar L, Watts G. 2009. Creation and use of a Cre recombinase transgenic database. Methods Mol Biol 530: 365-378.
13. Naiche LA, Papaioannou VE. 2007. Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis 45: 768-775.
14. Okudo T, Knoepfler PS, Eisenman RN, Hogan BLM. 2005. Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation. Development 132: 1363-1374.
15. Perl AK, Zhang L, Whitsett JA. 2009. Conditional expression of genes in the respiratory epithelium in transgenic mice. Am J Respir Cell Mol Biol 40: 1-3.
16. Schmidt EE, Taylor DS, Prigge JR, Barnett S, Capecchi MR. 2000. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc Natl Acad Sci USA 97: 13702-13707.
17. Semprini S, Troup TJ, Kotelevtseva N, King K, Davis JRE, Mullins LJ, Chapman KE, Dunbar DR, Mullins JJ. 2007. Cryptic loxP sites in mammalian genomes: Genome-wide distribution and relevance for the efficiency of BAC/PAC recombineering techniques. Nucleic Acids Res 35: 1402-1410.
18. Sisson TH, Hansen JM, Shah M, Hanson KE, Du M, Ling T, Simon RH, Christensen PJ. 2006. Expression of the reverse tetracycline-transactivator gene causes emphysema-like changes in mice. Am J Respir Cell Mol Biol 34: 552-560.
19. Soriano P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21: 70-71.
20. Tabariès S, Lemieux M, Aubin J, Jeannotte L. 2007. Comparative analysis of Hoxa5 allelic series. Genesis 45: 218-228.
21. Trainor PA, Zhou SX, Parameswaran M, Quinlan GA, Gordon M, Strum K, Tam PPL. 1999. Application of lacZ transgenic mice to cell lineage studies. Methods Mol Biol 97: 183-200.
22. Whitsett JA, Perl AK. 2006. Conditional control of gene expression in the respiratory epithelium. Am J Respir Cell Mol Biol 34: 519-520.