Expression and function of Toll-like receptors 2 and 4 in human keratinocytes

International Immunology

Volumn 15, Issue 6, 2003, Pages 721-730

  Pivarcsi, Andor ^a,b   Bodai, Laszlo ^a   Réthi, Bence ^c   Kenderessy Szabó, Anna ^a   Koreck, Andrea ^a   Széll, Márta ^b   Beer, Zsuzsanna ^d   Bata Csörgo, Zsuzsanna ^a,b   Magócsi, Mária ^e   Rajnavölgyi, Eva ^f   Dobozy, Attila ^a,b   Kemény, Lajos ^a,b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

^e National Institute of Haematology and Immunology Budapest   (Hungary)

^f UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Epidermis; Host defense; IL 8; Innate immunity; NF B

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DIFFERENTIATION INDUCING FACTOR; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MANNAN; MESSENGER RNA; NEUTRALIZING ANTIBODY; PEPTIDOGLYCAN; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANTIGEN EXPRESSION; ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CELL ACTIVITY; CELLULAR IMMUNITY; CONTROLLED STUDY; EPIDERMIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HOST RESISTANCE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFECTION RESISTANCE; INTRACELLULAR TRANSPORT; KERATINOCYTE; MYCOBACTERIUM TUBERCULOSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, DIFFERENTIATION; CANDIDA ALBICANS; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERFERON TYPE II; INTERLEUKIN-8; KERATINOCYTES; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MYCOBACTERIUM TUBERCULOSIS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PEPTIDOGLYCAN; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 0038281539     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxg068     Document Type: Article

References (51)

1. Medzhitov, R. and Janeway, C. A. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295.
2. Kopp, E. B. and Medzhitov, R. 1999. The Toll-receptor family and control of innate immunity. Curr. Opin. Immunol. 11:13.
3. Zhang, G. and Ghosh, S. 2001. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J. Clin. Invest. 107:13.
4. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749.
5. Takeuchi, O., Hoshino, K. and Akira, S. 2000. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165:5392.
6. Takeuchi, O., Takeda, K., Hoshino, K., Adachi, O., Ogawa, T. and Akira, S. 2000. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12:113.
7. Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J. and Gusovsky, F. 1999. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 274:10689.
8. Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L. and Schwartz, D. A. 2000. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25:187.
9. Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R. and Golenbock, D. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163:1.
10. Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A., Wilson, C. B., Bassetti, M. and Aderem, A. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401:811.
11. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K. and Akira, S. 1999. Differential roles of TLR2 and TLR4 in recognition of Gram- negative and Gram-positive bacterial cell wall components. Immunity 11:443.
12. Hirschfeld, M., Kirschning, C. J., Schwandner, R., Wesche, H., Weis, J. H., Wooten, R. M. and Weis, J. J. 1999. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163:2382.
13. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. and Kirschning, C. J. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274:17406.
14. Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R. B., Belisle, J. T., Bleharski, J. R., Maitland, M., Norgard, M. V., Plevy, S. E., Smale, S. T., Brennan, P. J., Bloom, B. R., Godowski, P. J. and Modlin, R. L. 1999. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285:732.
15. Aliprantis, A. O., Yang, R. B., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. and Zychlinsky, A. 1999. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor. Science 285:736.
16. Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., Carroll, J. D., Espevik, T., Ingalls, R. R., Radolf, J. D. and Golenbock, D. T. 1999. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274:33419.
17. Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C., Ghosh, S. and Janeway, C. A., Jr. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2:253.
18. Medzhitov, R. and Janeway, C. 2000. Innate immunity. N. Engl. J. Med. 343:338.
19. Anderson, K. V. 2000. Toll signaling pathways in the innate immune response. Curr. Opin. Immunol. 12:13.
20. Eckert, R. L. 1989. Structure, function, and differentiation of the keratinocyte. Physiol. Rev. 69:1316.
21. Hahn, B. L. and Sohnle, P. G. 1988. Characteristics of dermal invasion in experimental cutaneous candidiasis of leucopenic mice. J. Invest. Dermatol. 91:233.
22. Csato, M., Bozoky, B., Hunyadi, J. and Dobozy, A. 1986. Candida albicans phagocytosis by separated human epidermal cells. Arch. Dermatol. Res. 279:136.
23. Csato, M., Kenderessy, A. S. and Dobozy, A. 1987. Enhancement of Candida albicans killing activity of separated human epidermal cells by ultraviolet radiation. Br. J. Dermatol. 116:469.
24. Kirkpatrick, C. H., Rich, R. R. and Bennett, J. E. 1971. Chronic mucocutaneous candidiasis: model-building in cellular immunity. Ann. Intern. Med. 74:955.
25. Csato, M., Kenderessy, A. S. and Dobozy, A. 1989. Enhancement of Candida albicans killing activity of separated human epidermal cells by alpha-melanocyte stimulating hormone [Letter]. Br. J. Dermatol. 121:145.
26. Csato, M., Kenderessy, A. S., Judak, R. and Dobozy, A. 1990. Inflammatory mediators are involved in the Candida albicans killing activity of human epidermal cells. Arch. Dermatol. Res. 282:348.
27. Szolnoky, G., Bata-Csorgo, Z., Kenderessy, A. S., Kiss, M., Pivarcsi, A., Novak, Z., Nagy Newman, K., Michel, G., Ruzicka, T., Marodi, L., Dobozy, A. and Kemeny, L. 2001. A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans. J Invest. Dermatol. 117:205.
28. Bruch-Gerharz, D., Fehsel, K., Suschek, C., Michel, G., Ruzicka, T. and Kolb-Bachofen, V. 1996. A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J. Exp. Med. 184:2007.
29. Arany, I., Brysk, M. M., Brysk, H. and Tyring, S. K. 1996. Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes. Biochem. Biophys. Res. Commun. 220:618.
30. Bruch-Gerharz, D., Ruzicka, T. and Kolb-Bachofen, V. 1998. Nitric oxide in human skin: current status and future prospects. J Invest. Dermatol. 110:1.
31. Frohm, M., Agerberth, B., Ahangari, G., Stahle-Backdahl, M., Liden, S., Wigzell, H. and Gudmundsson, G. H. 1997. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J. Biol. Chem. 272:15258.
32. Wiedow, O., Harder, J., Bartels, J., Streit, V. and Christophers, E. 1998. Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes. Biochem. Biophys. Res. Commun. 248:904.
33. Harder, J., Bartels, J., Christophers, E. and Schroder, J. M. 1997. A peptide antibiotic from human skin [Letter] [see Comments]. Nature 387:861.
34. Harder, J., Bartels, J., Christophers, E. and Schroder, J. M. 2001. Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276:5707.
35. Kenderessy, A. S., Kemeny, L. and Dobozy, A. 1996. Nitric oxide is involved in the Candida albicans killing activity of keratinocytes. J. Invest. Dermatol. 107:452.
36. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115.
37. Song, P. I., Park, Y. M., Abraham, T., Harten, B., Zivony, A., Neparidze, N., Armstrong, C. A. and Ansel, J. C. 2002. Human keratinocytes express functional CD14 and toll-like receptor 4. J. Invest Dermatol. 119:424.
38. Faure E., Equils O., Sieling P. A., Thomas L., Zhang F. X., Kirschning C. J., Polentarutti N., Muzio M. and Arditi M. 2000. Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells. J. Biol. Chem. 275:11058.
39. Marodi, L., Korchak, H. M. and Johnston, R. B., Jr. 1991 Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages. J. Immunol. 146:2783.
40. Sawyer, R. T., Garner, R. E. and Hudson, J. A. 1992. Effect of lectins on hepatic clearance and killing of Candida albicans by the isolated perfused mouse liver. Infect. Immun. 60:1041.
41. Qin, J. Z., Chaturvedi, V., Denning, M. F., Choubey, D., Diaz, M. O. and Nickoloff, B. J. 1999. Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes. J. Biol. Chem. 274:37957.
42. Hoffmann, E., Dittrich-Breiholz O., Holtman H. and Kracht M. 2002. Multiple control of interleukin-8 gene expression. J. Leukoc. Biol. 72:847.
43. Hunyadi, J., Simon, M., Jr, Kenderessy, A. S. and Dobozy, A. 1993. Expression of monocyte/macrophage markers (CD13, CD14, CD68) on human keratinocytes in healthy and diseased skin. J. Dermatol. 20:341.
44. Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9:143.
45. Muzio, M., Bosisio, D., Polentarutti, N., D'amico, G., Stoppacciaro, A., Mancinelli, R., van't Veer, C., Penton-Rol, G., Ruco, L. P., Allavena, P. and Mantovani, A. 2001. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164:5998.
46. Matsuguchi, T., Musikacharoen, T., Ogawa, T. and Yoshikai, Y. 2001. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J. Immunol. 165:5767.
47. Kemeny, L., Ruzicka, T., Dobozy, A. and Michel, G. 1994. Role of interleukin-8 receptor in skin. Int. Arch. Allergy Immunol. 104:317.
48. Lucas, S. 1997. Bacterial diseases. In Elder, D., Elenitsas, R., Jaworsky, Ch. and Johnson, B., eds, Lever's Histopathology of the Skin, 8th edn, p. 457. Lippincott-Raven, Philadelphia, PA.
49. Longley, B. J. 1997. Fungal diseases. In Elder, D., Elenitsas, R., Jaworsky, Ch. and Johnson, B., eds, Lever's Histopathology of the Skin, 8th edn, p. 517. Lippincott-Raven, Philadelphia, PA.
50. Diamond, G., Kaiser, V., Rhodes, J., Russell, J. P. and Bevins, C. L. 2000. Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells. Infect. Immun. 68:113.
51. Wahl, C., Liptay, S., Adler, G. and Schmid, R. M. 1998. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J. Clin. Invest. 101:1163.