Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb

Development

Volumn 136, Issue 16, 2009, Pages 2825-2835

  Matsumoto, Kazu ^a   Li, Yingcui ^b   Jakuba, Caroline ^b   Sugiyama, Yoshinori ^a,c   Sayo, Tetsuya ^c   Okuno, Misako ^a   Dealy, Caroline N ^b   Toole, Bryan P ^d   Takeda, Junji ^e   Yamaguchi, Yu ^a   Kosher, Robert A ^b  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c KANEBO LTD   (Japan)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e OSAKA UNIVERSITY   (Japan)

Author keywords

Chondrocyte maturation; Has2; Hyaluronan; Joint development; Limb development; Mouse; Skeletal development

Indexed keywords

AGGRECAN; CRE RECOMBINASE; HYALURONAN SYNTHASE 2; HYALURONIC ACID; SYNTHETASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE GROWTH; CARTILAGE CELL; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE FUNCTION; GROWTH PLATE; HISTOGENESIS; JOINT FORMATION; LIMB BUD; LIMB DEVELOPMENT; MESODERM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; PHENOTYPE; PRIORITY JOURNAL; SYNOVIUM; TRANSGENE;

AGGRECANS; ANIMALS; BODY PATTERNING; BONE DEVELOPMENT; CELL PROLIFERATION; CHONDROCYTES; COLLAGEN TYPE X; EXTRACELLULAR MATRIX; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; GLUCURONOSYLTRANSFERASE; HEDGEHOG PROTEINS; HUMANS; HYALURONIC ACID; JOINTS; LIMB DEFORMITIES, CONGENITAL; MESODERM; MICE; MICE, KNOCKOUT;

MUS;

EID: 69049108804     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.038505     Document Type: Article

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